Actively Recruiting
A Study to Evaluate the Safety and Efficacy of a Single Dose of RABI-767 in Participants With Acute Pancreatitis
Led by Panafina, Inc. · Updated on 2026-04-03
36
Participants Needed
15
Research Sites
122 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to test the safety and effectiveness of a single dose of RABI-767 given by endoscopic ultrasound (EUS) guided peripancreatic injection in participants with predicted severe acute pancreatitis. The main question the study aims to answer is: • Is a single-dose of RABI-767 given by EUS-guided peripancreatic injection safe in patients with predicted severe acute pancreatitis. The study also aims to answer: • Is a single-dose of RABI-767 given by EUS-guided peripancreatic injection effective in treating patients with predicted severe acute pancreatitis. Study participants will be randomly assigned (like the flip of a coin) to receive a single dose of RABI-767 plus supportive care or supportive care only. The study sponsor will compare safety and efficacy data collected from participants who receive RABI-767 to participants who receive supportive care only to test if RABI-767 is safe and effective.
CONDITIONS
Official Title
A Study to Evaluate the Safety and Efficacy of a Single Dose of RABI-767 in Participants With Acute Pancreatitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of acute pancreatitis
- Predicted severe acute pancreatitis based on study criteria
- No meaningful improvement from admission status at randomization, as decided by investigator
- Suitable for EUS-guided study drug administration
- Available contrast-enhanced CT or MRI of abdomen/pancreas for evaluation
You will not qualify if you...
- Confirmed severe acute pancreatitis with persistent organ failure before randomization
- Expected hospital discharge within 48 hours of randomization
- More than 30% pancreatic necrosis on screening CT or MRI
- History of pancreatic necrosis or necrosectomy
- History of calcific chronic pancreatitis
- Evidence of cholangitis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 15 locations
1
University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States, 72205
Actively Recruiting
2
Keck Hospital of USC and LA County Hospital
Los Angeles, California, United States, 90033
Actively Recruiting
3
University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States, 80045
Actively Recruiting
4
University of Florida Health
Gainesville, Florida, United States, 32608
Actively Recruiting
5
Orlando Health
Orlando, Florida, United States, 32806
Actively Recruiting
6
UI Health, University of Illinois Chicago Hospital Health Sciences System
Chicago, Illinois, United States, 60612
Actively Recruiting
7
Indiana University Health University Hospital
Indianapolis, Indiana, United States, 46202
Withdrawn
8
Johns Hopkins Hospital
Baltimore, Maryland, United States, 21287
Actively Recruiting
9
Henry Ford Hospital
Detroit, Michigan, United States, 48202
Actively Recruiting
10
Dartmouth Hitchcock Medical Center
Lebanon, New Hampshire, United States, 03756
Actively Recruiting
11
NYU Langone Medical Center
New York, New York, United States, 10016
Actively Recruiting
12
Lisie Hospital
Kochi, Kerala, India, 682018
Actively Recruiting
13
Christian Medical College (CMC) Vellore, Ranipet Campus
Vellore, TamiNadu, India, 632517
Actively Recruiting
14
All India Institute of Medical Sciences
Delhi, India, 110029
Actively Recruiting
15
Govind Ballabh Pant Institute of Postgraduate Medical Education and Research
New Delhi, India, 110002
Actively Recruiting
Research Team
K
Kelly Abernathy
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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