Actively Recruiting
Study to Evaluate the Safety and Efficacy of Tapinarof in Adults With Palmoplantar Keratoderma
Led by Indiana University · Updated on 2026-03-04
6
Participants Needed
1
Research Sites
165 weeks
Total Duration
On this page
Sponsors
I
Indiana University
Lead Sponsor
O
Organon and Co
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to assess adults with palmoplantar keratoderma (thickening skin layer on palms and soles) who are treated with the study drug, tapinarof. This is a naturally occuring compound used for the treatment of psoriasis. This study is being done to find out how well and safe this drug is for stopping or treating keratoderma. This study aims to investigate the positive impacts of daily topical Tapinarof use in the improvement of Keratoderma. Clinical efficacy and safety profile of prescribing Tapinarof for this condition will be evaluated.
CONDITIONS
Official Title
Study to Evaluate the Safety and Efficacy of Tapinarof in Adults With Palmoplantar Keratoderma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Able to provide written informed consent and follow all study requirements
- Male or female adults aged 18 years or older
- Confirmed clinical diagnosis of palmoplantar keratoderma
You will not qualify if you...
- Use of topical corticosteroids, keratolytic agents, topical retinoids, topical vitamin D ointment, or oral retinoids during the study without a 2-week washout period
- Prior treatment with tapinarof
- Known or suspected hypersensitivity to tapinarof or similar drugs
- Participation in another clinical study for the same purpose
- Currently pregnant or confirmed pregnancy at screening
- Any other condition deemed unsuitable by the investigators
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Indiana University Department of Dermatology
Indianapolis, Indiana, United States, 46202
Actively Recruiting
Research Team
A
Austin Routh, MPH, CPH
CONTACT
F
Flossy Lincoln
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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