Actively Recruiting
A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of RO7268489 as Add-on Therapy to Ocrelizumab, in Participants With Progressive Forms of Multiple Sclerosis (MS)
Led by Hoffmann-La Roche · Updated on 2026-04-23
360
Participants Needed
47
Research Sites
220 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The main purpose of this study is to assess the efficacy of RO7268489 in adults with progressive multiple sclerosis (PMS) receiving ocrelizumab. After the end of the double-blind period, an open-label (OL) extension may allow eligible participants to receive open-label RO7268489.
CONDITIONS
Official Title
A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of RO7268489 as Add-on Therapy to Ocrelizumab, in Participants With Progressive Forms of Multiple Sclerosis (MS)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of progressive multiple sclerosis (PMS) according to the revised 2017 McDonald criteria
- Expanded Disability Status Scale (EDSS) score between 3.0 and 6.0 inclusive at screening
You will not qualify if you...
- Multiple sclerosis relapse within 6 months before randomization
- No peripheral venous access
- History of alcohol or drug abuse within 5 years prior to screening, as judged by the investigator
- Unable to complete a magnetic resonance imaging (MRI) scan
- Contraindications to mandatory ocrelizumab pre-medications
- Treatment with intravenous immunoglobulin (IV Ig) or plasmapheresis within 12 weeks before screening
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 47 locations
1
Southern Neurology
Kogarah, New South Wales, Australia, 2217
Actively Recruiting
2
Groupe Hospitalier Pellegrin
Bordeaux, Gironde, France, 33800
Actively Recruiting
3
Hopital Purpan
Toulouse, Haute Garonne, France, 31059
Actively Recruiting
4
Hopital Gui de Chauliac
Montpellier, Herault, France, 34295
Actively Recruiting
5
Groupe Hospitalier Pitie-Salpetriere
Paris, France, 75013
Actively Recruiting
6
CHU Rennes - Hopital Pontchaillou
Rennes, France, 35033
Actively Recruiting
7
Fondazione IRCCS Istituto Neurologico Carlo Besta
Milan, Lombardy, Italy, 20133
Actively Recruiting
8
Azienda Socio Sanitaria Territoriale Niguarda (Grande Ospedale Metropolitano Niguarda)
Milan, Lombardy, Italy, 20162
Actively Recruiting
9
Optimal Clinical Trials - Christchurch
Christchurch Central City, South Island, New Zealand, 8011
Actively Recruiting
10
Optimal Clinical Trials - Central
Auckland, New Zealand, 1010
Actively Recruiting
11
Nmedis sp. z o.o.
Rzeszw, Podkarpackie Voivodeship, Poland, 35-323
Actively Recruiting
12
Centrum Medyczne Pratia Katowice I
Katowice, Silesian Voivodeship, Poland, 40-081
Actively Recruiting
13
NEURO-CARE Sp. z o.o. Sp. Komandytowa
Katowice, Silesian Voivodeship, Poland, 40-749
Actively Recruiting
14
M.A. LEK A.M.Maciejowscy SC.
Katowice, Poland, 40-571
Actively Recruiting
15
Resmedica NZOZ Kielce
Kielce, Poland, 25-726
Actively Recruiting
16
Samodzielny Publiczny Zakad Opieki Zdrowotnej Szpital Uniwersytecki w Krakowie
Krakow, Poland, 31-503
Actively Recruiting
17
Szpital Specjalistyczny im. L. Rydygiera w Krakowie
Krakow, Poland, 31-826
Actively Recruiting
18
Indywidualna Praktyka Lekarska Prof. Dr Hab. N. Med. Konrad Rejdak.
Lublin, Poland, 20-410
Actively Recruiting
19
Zanamed Medical Clinic sp z o o
Lublin, Poland, 20-601
Actively Recruiting
20
Centrum Medyczne Medyk
Rzeszów, Poland, 35-055
Actively Recruiting
21
Centrum Medyczne NeuroProtect
Warsaw, Poland, 01-684
Actively Recruiting
22
Samodzielny Publiczny Szpital Kliniczny Nr 1 im. Prof. Stanislawa SzyszkoSUM w Katowicach
Zabrze, Poland, 41-800
Actively Recruiting
23
Hospital Santa Caterina
Salt, Girona, Spain, 17190
Actively Recruiting
24
Hospital Universitario Quironsalud Madrid
Pozuelo de Alarcón, Madrid, Spain, 28223
Actively Recruiting
25
Hospital Alvaro Cunqueiro
Vigo, Pontevedra, Spain, 36312
Actively Recruiting
26
Complejo Hospitalario Universitario de Albacete
Albacete, Spain, 02008
Actively Recruiting
27
Hospital del Mar
Barcelona, Spain, 08003
Actively Recruiting
28
Hospital Universitari Vall d Hebron
Barcelona, Spain, 08035
Actively Recruiting
29
Hospital Clinic de Barcelona
Barcelona, Spain, 08036
Actively Recruiting
30
Hospital Universitario de la Princesa
Madrid, Spain, 28006
Actively Recruiting
31
Hospital General Universitario Gregorio Maranon
Madrid, Spain, 28007
Actively Recruiting
32
Hospital Clinico San Carlos
Madrid, Spain, 28040
Actively Recruiting
33
Hospital Regional Universitario de Malaga
Málaga, Spain, 29010
Actively Recruiting
34
Hospital Universitario Virgen Macarena
Seville, Spain, 41009
Actively Recruiting
35
Hospital Universitari i Politecnic La Fe
Valencia, Spain, 46026
Actively Recruiting
36
Kocaeli University Medical Faculty
Kocaeli, Izmit, Turkey (Türkiye), 41380
Actively Recruiting
37
Hacettepe University of Medicine
Ankara, Turkey (Türkiye), 06100
Actively Recruiting
38
Gazi University Medical Faculty
Ankara, Turkey (Türkiye), 06500
Actively Recruiting
39
Ankara City Hospital
Ankara, Turkey (Türkiye), 06800
Actively Recruiting
40
Istanbul University Istanbul Medical Faculty
Istanbul, Turkey (Türkiye), 34093
Actively Recruiting
41
Istanbul University Cerrahpasa Medical Faculty
Istanbul, Turkey (Türkiye), 34098
Actively Recruiting
42
Sancaktepe Sehit Prof Dr Ilhan Varank Training and Research Hospital
Istanbul, Turkey (Türkiye), 34785
Actively Recruiting
43
Royal Cornwall Hospital
Truro, Cornwall, United Kingdom, TR1 3HD
Actively Recruiting
44
Charing Cross Hospital
London, Greater London, United Kingdom, W6 8RF
Actively Recruiting
45
Queen Elizabeth University Hospital
Glasgow, Strathclyde, United Kingdom, G51 4TF
Actively Recruiting
46
Salford Care Organisation
Salford, United Kingdom, M6 8HD
Actively Recruiting
47
Morriston Hospital
Swansea, United Kingdom, SA6 6NL
Actively Recruiting
Research Team
R
Reference Study ID Number: BP46016 https://forpatients.roche.com/
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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