Actively Recruiting
A Study to Evaluate Safety, PK, PD and Efficacy of AZD5492, a T Cell-engaging Antibody Targeting CD20 in Subjects With R/R B-Cell Malignancies.
Led by AstraZeneca · Updated on 2026-05-01
174
Participants Needed
30
Research Sites
177 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a Phase I/II study designed to evaluate if experimental T cell engaging antibody targeting CD20 AZD5492 is safe, tolerable and efficacious in participants with Relapsed or Refractory B-Cell Malignancies.
CONDITIONS
Official Title
A Study to Evaluate Safety, PK, PD and Efficacy of AZD5492, a T Cell-engaging Antibody Targeting CD20 in Subjects With R/R B-Cell Malignancies.
Who Can Participate
Eligibility Criteria
You may qualify if you...
-
≥18 years of age;
-
Histologically documented CD20+ mature B-cell neoplasm
- Large B-cell lymphoma
- Follicular lymphoma
- Mantle cell lymphoma
- Chronic lymphocytic leukemia
- Small lymphocytic lymphoma
-
Relapsed, progressive and/or refractory disease following at least 2 prior lines of therapy;
-
ECOG performance status of ≤ 2 (< 2 in EU countries).
The above is a summary, other inclusion criteria details may apply.
You will not qualify if you...
- Any neoplasm histology not specified in the IC section;
- Active CNS involvement in lymphoma;
- CNS pathology including but not limited to any history of seizure disorder/epilepsy;
- Prior allogeneic HSCT within 180 days, prior autologous HSCT within 90 days, or cell therapy within 90 days of start of therapy;
- History of Grade ≥ 3 CRS or Grade ≥ 3 ICANS;
- Active and uncontrolled infections;
- Unresolved AEs ≥2 Grade due to prior anticancer therapies, with some exceptions
The above is a summary, other exclusion criteria details may apply.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 30 locations
1
Research Site
La Jolla, California, United States, 92093
Actively Recruiting
2
Research Site
Boston, Massachusetts, United States, 02215
Withdrawn
3
Research Site
Rochester, Minnesota, United States, 55905
Not Yet Recruiting
4
Research Site
Hackensack, New Jersey, United States, 07601
Actively Recruiting
5
Research Site
New York, New York, United States, 10021
Actively Recruiting
6
Research Site
New York, New York, United States, 10029
Actively Recruiting
7
Research Site
Charlotte, North Carolina, United States, 28203
Actively Recruiting
8
Research Site
Winston-Salem, North Carolina, United States, 27157
Actively Recruiting
9
Research Site
Houston, Texas, United States, 77030
Actively Recruiting
10
Research Site
Seattle, Washington, United States, 98109
Actively Recruiting
11
Research Site
Melbourne, Australia, 3000
Actively Recruiting
12
Research Site
Nedlands, Australia, 6009
Actively Recruiting
13
Research Site
Calgary, Alberta, Canada, T2N 5G2
Actively Recruiting
14
Research Site
Toronto, Ontario, Canada, M5G 2M9
Actively Recruiting
15
Research Site
Montreal, Quebec, Canada, H3T 1R2
Actively Recruiting
16
Research Site
Hangzhou, China, 310003
Actively Recruiting
17
Research Site
Shanghai, China, 200025
Actively Recruiting
18
Research Site
København Ø, Denmark, 2100
Actively Recruiting
19
Research Site
Pessac, France, 33604
Actively Recruiting
20
Research Site
Villejuif, France, 94805
Actively Recruiting
21
Research Site
München, Germany, 81675
Actively Recruiting
22
Research Site
Ulm, Germany, 89081
Actively Recruiting
23
Research Site
Würzburg, Germany, 97080
Actively Recruiting
24
Research Site
Bologna, Italy, 40138
Actively Recruiting
25
Research Site
Milan, Italy, 20133
Actively Recruiting
26
Research Site
Chūōku, Japan, 104-0045
Actively Recruiting
27
Research Site
Kashiwa, Japan, 277-8577
Actively Recruiting
28
Research Site
Barcelona, Spain, 08035
Actively Recruiting
29
Research Site
L'Hospitalet de Llobregat, Spain, 08908
Actively Recruiting
30
Research Site
Madrid, Spain, 28040
Actively Recruiting
Research Team
A
AstraZeneca Clinical Study Information Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
1
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