Actively Recruiting

Phase 1
Phase 2
Age: 18Years +
All Genders
NCT06542250

A Study to Evaluate Safety, PK, PD and Efficacy of AZD5492, a T Cell-engaging Antibody Targeting CD20 in Subjects With R/R B-Cell Malignancies.

Led by AstraZeneca · Updated on 2026-05-01

174

Participants Needed

30

Research Sites

177 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This is a Phase I/II study designed to evaluate if experimental T cell engaging antibody targeting CD20 AZD5492 is safe, tolerable and efficacious in participants with Relapsed or Refractory B-Cell Malignancies.

CONDITIONS

Official Title

A Study to Evaluate Safety, PK, PD and Efficacy of AZD5492, a T Cell-engaging Antibody Targeting CD20 in Subjects With R/R B-Cell Malignancies.

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • ≥18 years of age;

  • Histologically documented CD20+ mature B-cell neoplasm

    • Large B-cell lymphoma
    • Follicular lymphoma
    • Mantle cell lymphoma
    • Chronic lymphocytic leukemia
    • Small lymphocytic lymphoma
  • Relapsed, progressive and/or refractory disease following at least 2 prior lines of therapy;

  • ECOG performance status of ≤ 2 (< 2 in EU countries).

The above is a summary, other inclusion criteria details may apply.

Not Eligible

You will not qualify if you...

  • Any neoplasm histology not specified in the IC section;
  • Active CNS involvement in lymphoma;
  • CNS pathology including but not limited to any history of seizure disorder/epilepsy;
  • Prior allogeneic HSCT within 180 days, prior autologous HSCT within 90 days, or cell therapy within 90 days of start of therapy;
  • History of Grade ≥ 3 CRS or Grade ≥ 3 ICANS;
  • Active and uncontrolled infections;
  • Unresolved AEs ≥2 Grade due to prior anticancer therapies, with some exceptions

The above is a summary, other exclusion criteria details may apply.

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 30 locations

1

Research Site

La Jolla, California, United States, 92093

Actively Recruiting

2

Research Site

Boston, Massachusetts, United States, 02215

Withdrawn

3

Research Site

Rochester, Minnesota, United States, 55905

Not Yet Recruiting

4

Research Site

Hackensack, New Jersey, United States, 07601

Actively Recruiting

5

Research Site

New York, New York, United States, 10021

Actively Recruiting

6

Research Site

New York, New York, United States, 10029

Actively Recruiting

7

Research Site

Charlotte, North Carolina, United States, 28203

Actively Recruiting

8

Research Site

Winston-Salem, North Carolina, United States, 27157

Actively Recruiting

9

Research Site

Houston, Texas, United States, 77030

Actively Recruiting

10

Research Site

Seattle, Washington, United States, 98109

Actively Recruiting

11

Research Site

Melbourne, Australia, 3000

Actively Recruiting

12

Research Site

Nedlands, Australia, 6009

Actively Recruiting

13

Research Site

Calgary, Alberta, Canada, T2N 5G2

Actively Recruiting

14

Research Site

Toronto, Ontario, Canada, M5G 2M9

Actively Recruiting

15

Research Site

Montreal, Quebec, Canada, H3T 1R2

Actively Recruiting

16

Research Site

Hangzhou, China, 310003

Actively Recruiting

17

Research Site

Shanghai, China, 200025

Actively Recruiting

18

Research Site

København Ø, Denmark, 2100

Actively Recruiting

19

Research Site

Pessac, France, 33604

Actively Recruiting

20

Research Site

Villejuif, France, 94805

Actively Recruiting

21

Research Site

München, Germany, 81675

Actively Recruiting

22

Research Site

Ulm, Germany, 89081

Actively Recruiting

23

Research Site

Würzburg, Germany, 97080

Actively Recruiting

24

Research Site

Bologna, Italy, 40138

Actively Recruiting

25

Research Site

Milan, Italy, 20133

Actively Recruiting

26

Research Site

Chūōku, Japan, 104-0045

Actively Recruiting

27

Research Site

Kashiwa, Japan, 277-8577

Actively Recruiting

28

Research Site

Barcelona, Spain, 08035

Actively Recruiting

29

Research Site

L'Hospitalet de Llobregat, Spain, 08908

Actively Recruiting

30

Research Site

Madrid, Spain, 28040

Actively Recruiting

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Research Team

A

AstraZeneca Clinical Study Information Center

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SEQUENTIAL

Primary Purpose

TREATMENT

Number of Arms

1

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A Study to Evaluate Safety, PK, PD and Efficacy of AZD5492, a T Cell-engaging Antibody Targeting CD20 in Subjects With R/R B-Cell Malignancies. | DecenTrialz