Actively Recruiting
Study to Evaluate Safety, Tolerability and Drug Levels of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)
Led by Bristol-Myers Squibb · Updated on 2026-05-08
208
Participants Needed
117
Research Sites
138 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate the safety, tolerability, and exposure-response (E-R) of BMS-986435/MYK-224 in participants with symptomatic Heart Failure with Preserved Ejection Fraction (HFpEF).
CONDITIONS
Official Title
Study to Evaluate Safety, Tolerability and Drug Levels of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult participants with stable, symptomatic HFpEF with a normal heart pumping ability.
You will not qualify if you...
- No known diagnosis of obstructive or genetic hypertrophic cardiomyopathy or infiltrative/storage disorders like cardiac amyloidosis.
- No acute or serious conditions that could interfere with study assessments or pose a participant risk.
- Other protocol-defined inclusion/exclusion criteria apply.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 117 locations
1
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35233
Actively Recruiting
2
Colorado Heart and Vascular - Lakewood
Lakewood, Colorado, United States, 80228-1710
Actively Recruiting
3
Ascension St. Vincent's Riverside Hospital - PPDS
Jacksonville, Florida, United States, 32204-4748
Actively Recruiting
4
Local Institution - 0003
Miami, Florida, United States, 33133-4223
Active, Not Recruiting
5
University of Miami FL Miller School of Medicine -1120 NW 14th St
Miami, Florida, United States, 33136-2107
Actively Recruiting
6
Local Institution - 0014
Atlanta, Georgia, United States, 30322-1013
Withdrawn
7
Local Institution - 0048
Atlanta, Georgia, United States, 30322-1013
Withdrawn
8
Bluhm Cardiovascular Institute of Northwestern
Chicago, Illinois, United States, 60611-5969
Actively Recruiting
9
Chicago Medical Research, LLC - Hazel Crest
Hazel Crest, Illinois, United States, 60429-2196
Actively Recruiting
10
Ascension Medical Group St. Vincent - Indianapolis Heart Care
Indianapolis, Indiana, United States, 46260-1992
Actively Recruiting
11
Local Institution - 0045
Indianapolis, Indiana, United States, 46260-1992
Withdrawn
12
St. Louis Heart and Vascular
St Louis, Missouri, United States, 63136-6111
Actively Recruiting
13
Local Institution - 0043
St Louis, Missouri, United States, 63136
Withdrawn
14
Local Institution - 0117
Hackensack, New Jersey, United States, 07601-1915
Not Yet Recruiting
15
Capital Cardiology Associates
Albany, New York, United States, 12211
Actively Recruiting
16
Local Institution - 0105
Brooklyn, New York, United States, 11215
Not Yet Recruiting
17
Weill Cornell Medicine
New York, New York, United States, 10065-4805
Actively Recruiting
18
University of Rochester Medical Center - PPDS
Rochester, New York, United States, 14618-2668
Actively Recruiting
19
Rochester General Hospital Center for Clinical Research
Rochester, New York, United States, 14621
Actively Recruiting
20
Laurelton Heart Specialist PC - MyClinical - PPDS
Rosedale, New York, United States, 11422-1320
Actively Recruiting
21
Duke Cardiology Clinic - PPDS
Durham, North Carolina, United States, 27710-4000
Actively Recruiting
22
Local Institution - 0058
Cincinnati, Ohio, United States, 45242
Withdrawn
23
Local Institution - 0041
Oklahoma City, Oklahoma, United States, 73135-2607
Withdrawn
24
South Oklahoma Heart Research
Oklahoma City, Oklahoma, United States, 73135-2607
Actively Recruiting
25
Abington Memorial Hospital
Abington, Pennsylvania, United States, 19001
Actively Recruiting
26
Tennessee Center for Clinical Trials
Tullahoma, Tennessee, United States, 37388-8260
Actively Recruiting
27
Local Institution - 0104
Austin, Texas, United States, 78756-4080
Not Yet Recruiting
28
University of Texas Southwestern Medical Center
Dallas, Texas, United States, 75390
Actively Recruiting
29
Angiocardiac Care of Texas - PA - PPDS
Houston, Texas, United States, 77025-5253
Actively Recruiting
30
Local Institution - 0051
Houston, Texas, United States, 77025-5253
Withdrawn
31
Local Institution - 0066
Falls Church, Virginia, United States, 22042-1262
Withdrawn
32
Corporación Médica de General San Martín
Ciudad del Libertador General San Martin, Buenos Aires, Argentina, B1650BNB
Actively Recruiting
33
Local Institution - 0107
Zárate, Buenos Aires, Argentina, B2800DGH
Withdrawn
34
Local Institution - 0115
Zárate, Buenos Aires, Argentina, B2800DGH
Not Yet Recruiting
35
Local Institution - 0090
Córdoba, Córdoba Province, Argentina, 5000
Not Yet Recruiting
36
Local Institution - 0053
Córdoba, Córdoba Province, Argentina, X5003DCE
Not Yet Recruiting
37
Local Institution - 0073
Rosario, Santa Fe Province, Argentina, 2000
Not Yet Recruiting
38
IPR-Investigaciones en Patologías Respiratorias
San Miguel de Tucumán, Tucumán Province, Argentina, T4000IAP
Actively Recruiting
39
Centro de Especialidades Médicas CEMEDIC
Buenos Aires, Argentina, 1407
Actively Recruiting
40
Local Institution - 0068
Buenos Aires, Argentina, C1179AAB
Withdrawn
41
Local Institution - 0067
Buenos Aires, Argentina, C1431FWO
Not Yet Recruiting
42
Sanatorio Duarte Quirós
Córdoba, Argentina, X5000AOQ
Actively Recruiting
43
Local Institution - 0069
Salta, Argentina, A4406BPF
Not Yet Recruiting
44
Centro de Investigaciones Clínicas Del Litoral SRL
Santa Fe, Argentina, S3000FWO
Actively Recruiting
45
Hamilton General Hospital
Hamilton, Ontario, Canada, L8L 2X2
Actively Recruiting
46
Medicus MFC Inc.
Toronto, Ontario, Canada, M4P 1E4
Actively Recruiting
47
Local Institution - 0030
Toronto, Ontario, Canada, M5S 1B2
Withdrawn
48
Local Institution - 0040
Toronto, Ontario, Canada, M5S 1B2
Withdrawn
49
Local Institution - 0011
Montreal, Quebec, Canada, H1T 1C8
Withdrawn
50
Local Institution - 0035
Trois-Rivières, Quebec, Canada, G9A 1Y1
Withdrawn
51
Peking Union Medical College Hospital - East Campus
Beijing, Beijing Municipality, China, 100730
Actively Recruiting
52
Guangdong Provincial People's Hospital
Guangzhou, Guangdong, China, 510120
Actively Recruiting
53
The First Affiliated Hospital of Henan Science and Technology University - Jinghua Campus
Luoyang, Henan, China, 471003
Actively Recruiting
54
The Second Xiangya Hospital of Central South University
Changsha, Hunan, China, 410011
Actively Recruiting
55
The Second Affiliated Hospital, Zhejiang University School of Medicine - Jiefanglu Campus
Hangzhou, Zhejiang, China, 310009
Actively Recruiting
56
Local Institution - 0109
Jerusalem, Jerusalem, Israel, 90000
Not Yet Recruiting
57
Local Institution - 0113
Jerusalem, Jerusalem, Israel, 9103102
Not Yet Recruiting
58
Local Institution - 0111
Beersheba, Israel, 84101
Not Yet Recruiting
59
Local Institution - 0112
Be’er Ya‘aqov, Israel, 7033001
Not Yet Recruiting
60
Local Institution - 0108
Haifa, Israel, 3109601
Not Yet Recruiting
61
Local Institution - 0110
Petah Tikva, Israel, 49100
Not Yet Recruiting
62
Local Institution - 0106
Rehovot, Israel, 76100
Not Yet Recruiting
63
ZIV Medical Center
Safed, Israel, 1311001
Actively Recruiting
64
Local Institution - 0027
Foggia, Apulia, Italy, 71100
Withdrawn
65
Local Institution - 0038
Foggia, Apulia, Italy, 71100
Withdrawn
66
Local Institution - 0019
Naples, Campania, Italy, 80131
Completed
67
Local Institution - 0023
Milan, Lombardy, Italy, 20162
Withdrawn
68
Local Institution - 0033
Milan, Lombardy, Italy, 20162
Withdrawn
69
IRCCS Policlinico San Donato
San Donato Milanese, Lombardy, Italy, 20097
Actively Recruiting
70
Local Institution - 0050
San Donato Milanese, Lombardy, Italy, 20097
Withdrawn
71
Local Institution - 0052
Massa, Tuscany, Italy, 54100
Withdrawn
72
Local Institution - 0009
Bergamo, Italy, 24127
Completed
73
Local Institution - 0017
Pisa, Italy, 56124
Completed
74
Hyogo Prefectural Harima-Himeji General Medical Center
Himeji-Shi, Hyōgo, Japan, 672-8044
Actively Recruiting
75
National Hospital Organization Kanazawa Medical Center
Kanazawa, Ishikawa-ken, Japan, 920-8650
Actively Recruiting
76
Okayama Rosai Hospital
Okayama, Okayama-ken, Japan, 702-8055
Actively Recruiting
77
Kishiwada Tokushukai Hospital
Kishiwada, Osaka, Japan, 596-0042
Actively Recruiting
78
Takatsuki Red Cross Hospital
Takatsuki-Shi, Osaka, Japan, 569-1045
Actively Recruiting
79
Clinical Trials UMED Sp. z o.o.
Lódz, Lódzkie, Poland, 92-213
Actively Recruiting
80
Local Institution - 0031
Bialystok, Podlaskie Voivodeship, Poland, 15-276
Completed
81
Local Institution - 0044
Bialystok, Podlaskie Voivodeship, Poland, 15-276
Withdrawn
82
Local Institution - 0020
Lublin, Woj. Lubelskie, Poland, 20090
Withdrawn
83
Local Institution - 0049
Lublin, Woj. Lubelskie, Poland, 20090
Withdrawn
84
Local Institution - 0006
Krakow, Poland, 30-082
Withdrawn
85
Local Institution - 0024
Oświęcim, Poland, 51162
Withdrawn
86
Chungnam National University Hospital
Daejeon, Daejeon Gwang'yeogsi, South Korea, 35015
Actively Recruiting
87
Inha University Hospital
Junggu, Incheon Gwang'yeogsi, South Korea, 22332
Actively Recruiting
88
Severance Hospital Yonsei University Health System
Seoul, Seoul Teugbyeolsi, South Korea, 03722
Actively Recruiting
89
The Catholic University of Korea, Seoul St. Mary's Hospital
Seoul, Seoul Teugbyeolsi, South Korea, 06591
Actively Recruiting
90
Seoul National University Hospital
Seoul, Seoul Teugbyeolsi, South Korea, 3080
Actively Recruiting
91
Pusan National University Hospital
Busan, South Korea, 49241
Actively Recruiting
92
Keimyung University Dongsan Hospital
Daegu, South Korea, 42601
Actively Recruiting
93
Chonnam National University Hospital
Gwangju, South Korea, 61469
Actively Recruiting
94
Seoul National University Bundang Hospital
Seongnam-si, South Korea, 0
Actively Recruiting
95
Samsung Medical Center
Seoul, South Korea, 6351
Actively Recruiting
96
Local Institution - 0012
L'Hospitalet de Llobregat, Barcelona, Spain, 08907
Completed
97
Local Institution - 0025
Majadahonda, Madrid, Spain, 28222
Completed
98
Local Institution - 0047
Majadahonda, Madrid, Spain, 28222
Withdrawn
99
Hospital Universitario Virgen de La Arrixaca
El Palmar, Murcia, Spain, 30120
Actively Recruiting
100
Local Institution - 0039
El Palmar, Murcia, Spain, 30120
Withdrawn
101
Local Institution - 0042
Málaga, Málaga, Spain, 29010
Withdrawn
102
Local Institution - 0026
Madrid, Spain, 28034
Completed
103
Local Institution - 0034
Madrid, Spain, 28034
Withdrawn
104
Local Institution - 0032
Málaga, Spain, 29010
Active, Not Recruiting
105
Hospital Nuestra Señora de Valme
Seville, Spain, 41014
Actively Recruiting
106
Local Institution - 0046
Seville, Spain, 41014
Withdrawn
107
Local Institution - 0010
Valencia, Spain, 46010
Completed
108
Northwick Park Hospital
Harrow, Greater London, United Kingdom, HA1 3UJ
Actively Recruiting
109
North Tyneside General Hospital
North Shields, Northumberland, United Kingdom, NE29 8NH
Actively Recruiting
110
Leeds General Infirmary - PPDS
Leeds, Yorkshire, United Kingdom, LS1 3EX
Actively Recruiting
111
Local Institution - 0057
Sheffield, Yorkshire, United Kingdom, S5 7AU
Withdrawn
112
Bristol Royal Infirmary
Bristol, United Kingdom, BS2 8HW
Actively Recruiting
113
Local Institution - 0097
Dundee, United Kingdom, DD1 9SY
Not Yet Recruiting
114
Local Institution - 0075
London, United Kingdom, SE1 7EH
Not Yet Recruiting
115
John Radcliffe Hospital
Oxford, United Kingdom, OX3 9DU
Actively Recruiting
116
University Hospital of North Tees
Stockton-on-Tees, United Kingdom, TS19 8PE
Actively Recruiting
117
New Cross Hospital
Wolverhampton, United Kingdom, WV10 0QP
Actively Recruiting
Research Team
B
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
CONTACT
F
First line of the email MUST contain NCT # and Site #.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here