Actively Recruiting
A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors
Led by Bristol-Myers Squibb · Updated on 2026-05-07
416
Participants Needed
64
Research Sites
316 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate the safety, tolerability, drug levels, and preliminary efficacy of BMS-986507 combinations in adult participants with advanced solid tumors.
CONDITIONS
Official Title
A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants must have at least one measurable lesion according to solid tumor response criteria.
- Participants must have an ECOG Performance Status of 0 or 1.
- Participants must have a life expectancy of at least 3 months at first dose.
- Group A: Locally advanced or metastatic NSCLC with specific EGFR mutations, including exon 19 deletion, L858R in exon 21, or other allowed mutations.
- Group B: Locally advanced or metastatic NSCLC.
- Group C: Locally advanced, recurrent inoperable, or metastatic triple-negative breast cancer or ER-low, HER2-negative breast cancer.
- Group D: Locally advanced, recurrent inoperable, or metastatic triple-negative breast cancer per ASCO/CAP criteria.
- Group E: Locally advanced or metastatic NSCLC not suitable for curative treatment.
You will not qualify if you...
- Participants must not have mixed Small Cell Lung Cancer and Non-Small Cell Lung Cancer histology.
- Participants with known EGFR mutations are excluded in Groups A, B, and E.
- Participants must not have a history of serious recurrent infections.
- Participants must not have a history of severe heart disease.
- Other protocol-defined inclusion/exclusion criteria apply.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 64 locations
1
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35294
Actively Recruiting
2
University of Miami Hospital and Clinics, Sylvester Cancer Center
Miami, Florida, United States, 33136
Actively Recruiting
3
Local Institution - 0125
Maywood, Illinois, United States, 60153
Not Yet Recruiting
4
Local Institution - 0065
Iowa City, Iowa, United States, 52242
Not Yet Recruiting
5
John Theurer Cancer Center at Hackensack University Medical Center
Hackensack, New Jersey, United States, 07601
Actively Recruiting
6
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Actively Recruiting
7
Local Institution - 0102
Columbus, Ohio, United States, 43212
Not Yet Recruiting
8
Local Institution - 0134
Portland, Oregon, United States, 97225
Not Yet Recruiting
9
Local Institution - 0052
Portland, Oregon, United States, 97239
Not Yet Recruiting
10
Local Institution - 0090
Portland, Oregon, United States, 97239
Not Yet Recruiting
11
Local Institution - 0014
Pittsburgh, Pennsylvania, United States, 15232
Withdrawn
12
Local Institution - 0103
Knoxville, Tennessee, United States, 37920
Not Yet Recruiting
13
NEXT Oncology - Irving
Irving, Texas, United States, 75039
Actively Recruiting
14
Swedish Medical Center
Seattle, Washington, United States, 98104
Actively Recruiting
15
Liverpool Hospital
Liverpool, New South Wales, Australia, 2170
Actively Recruiting
16
Princess Alexandra Hospital
Woolloongabba, Queensland, Australia, 4102
Actively Recruiting
17
Local Institution - 0108
East Melbourne, Victoria, Australia, 3002
Not Yet Recruiting
18
Local Institution - 0101
Subiaco, Western Australia, Australia, 6008
Not Yet Recruiting
19
Cross Cancer Institute
Edmonton, Alberta, Canada, T6G 1Z2
Actively Recruiting
20
Local Institution - 0064
Newmarket, Ontario, Canada, L3Y 2P9
Not Yet Recruiting
21
Local Institution - 0023
Ottawa, Ontario, Canada, K1H 8L6
Withdrawn
22
The Ottawa Hospital - General Campus
Ottawa, Ontario, Canada, K1H 8L6
Actively Recruiting
23
Centre Hospitalier de l'Université de Montréal
Montreal, Quebec, Canada, H2X 3E4
Actively Recruiting
24
Jewish General Hospital
Montreal, Quebec, Canada, H3T 1E2
Actively Recruiting
25
Local Institution - 0105
Valdivia, Los Ríos Region, Chile, 5112129
Not Yet Recruiting
26
Local Institution - 0048
Santiago, Santiago Metropolitan, Chile, 7500921
Not Yet Recruiting
27
Local Institution - 0049
Santiago, Santiago Metropolitan, Chile, 8330032
Not Yet Recruiting
28
Local Institution - 0047
Santiago, Santiago Metropolitan, Chile, 8420383
Not Yet Recruiting
29
Local Institution - 0107
Viña del Mar, Valparaiso, Chile, 2520598
Not Yet Recruiting
30
Local Institution - 0077
Nice, Alpes-Maritimes, France, 06189
Withdrawn
31
Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest
Bordeaux, Aquitaine, France, 33076
Actively Recruiting
32
Centre Leon Berard
Lyon, Auvergne-Rhône-Alpes, France, 69008
Actively Recruiting
33
Assistance Publique Hôpitaux de Marseille - Hôpital de la Timone
Marseille, Bouches-du-Rhône, France, 13385
Actively Recruiting
34
Local Institution - 0076
Caen, Calvados, France, 14076
Not Yet Recruiting
35
Hôpital Arnaud de Villeneuve - CHU Montpellier
Montpellier, Hérault, France, 34090
Actively Recruiting
36
Gustave Roussy
Villejuif, Val-de-Marne, France, 94800
Actively Recruiting
37
Institut Curie
Paris, France, 75248
Actively Recruiting
38
Hôpital Tenon
Paris, France, 75970
Actively Recruiting
39
Cro-Irccs
Aviano, Friuli Venezia Giulia, Italy, 33081
Actively Recruiting
40
Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, Lombardy, Italy, 20133
Actively Recruiting
41
Istituto di Candiolo IRCCS - Fondazione del Piemonte per l'Oncologia
Candiolo, Torino, Italy, 10060
Actively Recruiting
42
Azienda Ospedaliera Universitaria Careggi
Florence, Tuscany, Italy, 50134
Actively Recruiting
43
Local Institution - 0110
Ancona, Italy, 60126
Not Yet Recruiting
44
Local Institution - 0093
Milan, Italy, 20141
Not Yet Recruiting
45
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore
Roma, Italy, 00168
Actively Recruiting
46
Leids Universitair Medisch Centrum
Leiden, South Holland, Netherlands, 2333 ZA
Actively Recruiting
47
Nederlands Kanker Instituut Antoni van Leeuwenhoek (NKI AVL)
Amsterdam, Netherlands, 1066 CX
Actively Recruiting
48
CHUS - Hospital Clinico Universitario
Santiago de Compostela, A Coruña [La Coruña], Spain, 15706
Actively Recruiting
49
Hospital Universitari Vall d'Hebron
Barcelona, Barcelona [Barcelona], Spain, 08035
Actively Recruiting
50
Institut Català d'Oncologia - L'Hospitalet
Hospitalet, Barcelona [Barcelona], Spain, 08907
Actively Recruiting
51
Local Institution - 0059
Barcelona, Catalunya [Cataluña], Spain, 08036
Withdrawn
52
Hospital Universitario 12 de Octubre
Madrid, Madrid, Comunidad de, Spain, 28041
Actively Recruiting
53
Hospital Universitario Puerta de Hierro Majadahonda
Majadahonda, Madrid, Comunidad de, Spain, 28222
Actively Recruiting
54
Local Institution - 0118
Valencia, Valenciana, Comunitat, Spain, 46010
Not Yet Recruiting
55
Hospital Universitario Fundación Jiménez Díaz
Madrid, Spain, 28040
Actively Recruiting
56
Local Institution - 0127
Madrid, Spain, 28040
Not Yet Recruiting
57
Hospital Universitario HM Sanchinarro
Madrid, Spain, 28050
Actively Recruiting
58
H.R.U Málaga - Hospital General
Málaga, Spain, 29011
Actively Recruiting
59
Local Institution - 0112
Seville, Spain, 41009
Not Yet Recruiting
60
Hospital Universitari i Politecnic La Fe
Valencia, Spain, 46026
Actively Recruiting
61
Royal Free Hospital
London, England, United Kingdom, NW32QG
Actively Recruiting
62
Local Institution - 0021
Glasgow, Glasgow City, United Kingdom, G12 0YN
Not Yet Recruiting
63
University Hospitals Birmingham NHS Foundation Trust
Birmingham, West Midlands, United Kingdom, B15 2GW
Actively Recruiting
64
Local Institution - 0001
Newcastle upon Tyne, United Kingdom, NE7 7DN
Not Yet Recruiting
Research Team
B
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
CONTACT
F
First line of the email MUST contain NCT # and Site #.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
5
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