Actively Recruiting
A Study to Evaluate the Safety, Tolerability, and Drug Levels of BMS-986454 in Participants With Rheumatoid Arthritis
Led by Bristol-Myers Squibb · Updated on 2026-05-07
46
Participants Needed
9
Research Sites
77 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate the safety, tolerability, and drug levels of BMS-986454 in participants with Rheumatoid Arthritis
CONDITIONS
Official Title
A Study to Evaluate the Safety, Tolerability, and Drug Levels of BMS-986454 in Participants With Rheumatoid Arthritis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants with Rheumatoid Arthritis must have onset after age 18.
- Participants who meet 2010 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) classification criteria for RA.
- Participants must have evidence of swelling in at least 1 joint of the hand or wrist by clinical examination at screening and Day -1.
- Participants must have been an incomplete responder to prior methotrexate (MTX) treatment.
You will not qualify if you...
- Participants must not have any significant medical condition, other than Rheumatoid Arthritis, that substantially increases risk in the Investigator's judgment.
- Participants must not have any condition aside from RA that confounds the ability to interpret study data.
- Participants must not have severe Rheumatoid Arthritis as assessed by Disease Activity Score 28 c-reactive protein (DAS28-CRP) at screening or Day -1.
- Other protocol-defined Inclusion/Exclusion criteria apply.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 9 locations
1
Local Institution - 0006
Hyderabad, Andhra Pradesh, India, 500 082
Not Yet Recruiting
2
Local Institution - 0004
Ahmedabad, Gujarat, India, 382428
Not Yet Recruiting
3
Local Institution - 0003
Bangalore, Karnataka, India, 560 034
Not Yet Recruiting
4
Local Institution - 0009
Mysuru, Karnataka, India, 5700004
Not Yet Recruiting
5
All India Institute of Medical Sciences (AIIMS) - Nagpur
Nagpur, Maharashtra, India, 441108
Actively Recruiting
6
Life Point Mutispecialty Hospital Pvt. Ltd.
Pune, Maharashtra, India, 411057
Actively Recruiting
7
Kalinga Institute of Medical Sciences- Bhubaneswar
Bhubaneswar, Odisha, India, 751024
Actively Recruiting
8
Local Institution - 0002
Hyderabad, Telangana, India, 500004
Not Yet Recruiting
9
Krishna Institute of Medical Sciences Limited
Secunderabad, Telangana, India, 500003
Actively Recruiting
Research Team
B
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
CONTACT
F
First line of the email MUST contain NCT # and Site #.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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