Actively Recruiting
A Study to Evaluate the Safety, Tolerability, and Efficacy of Escalating Doses of BMS-986463 in Participants With Select Advanced Malignant Tumors.
Led by Bristol-Myers Squibb · Updated on 2026-04-15
240
Participants Needed
17
Research Sites
223 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate the safety, tolerability, and efficacy of escalating doses of BMS-986463 in participants with select advanced malignant tumors.
CONDITIONS
Official Title
A Study to Evaluate the Safety, Tolerability, and Efficacy of Escalating Doses of BMS-986463 in Participants With Select Advanced Malignant Tumors.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants must have an Eastern Cooperative Oncology Group Performance Status of 0 or 1.
- Participants must have at least 1 lesion accessible for biopsy in addition to the target lesion, from which a fresh pre treatment biopsy must be obtained.
- Participants must have an unresectable/metastatic carcinoma.
You will not qualify if you...
- Participants must not have Leptomeningeal metastases.
- Participants must not have concurrent malignancy (present during screening) requiring treatment or history of prior malignancy active within 2 years prior to treatment.
- Participants must not have had any prior radiation therapy within 2 weeks prior to start of study treatment.
- Other protocol-defined Inclusion/Exclusion criteria apply.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 17 locations
1
USC/Norris Comprehensive Cancer Center
Los Angeles, California, United States, 90033
Actively Recruiting
2
Valkyrie Clinical Trials
Los Angeles, California, United States, 90067
Actively Recruiting
3
John Theurer Cancer Center at Hackensack University Medical Center
Hackensack, New Jersey, United States, 07601
Actively Recruiting
4
Local Institution - 0045
Columbus, Ohio, United States, 43210
Not Yet Recruiting
5
Local Institution - 0046
Dallas, Texas, United States, 75390
Not Yet Recruiting
6
Local Institution - 0049
Houston, Texas, United States, 77054
Not Yet Recruiting
7
BC Cancer Vancouver
Vancouver, British Columbia, Canada, V5Z 4E6
Actively Recruiting
8
Princess Margaret Cancer Centre
Toronto, Ontario, Canada, M5G 2M9
Actively Recruiting
9
Centre Hospitalier de l'Université de Montréal
Montreal, Quebec, Canada, H2X 3E4
Actively Recruiting
10
Jewish General Hospital
Montreal, Quebec, Canada, H3T 1E2
Actively Recruiting
11
Local Institution - 0036
Bordeaux, Aquitaine, France, 33076
Not Yet Recruiting
12
Local Institution - 0031
Villejuif, Val-de-Marne, France, 94800
Not Yet Recruiting
13
Local Institution - 0035
Lyon, France, 69373
Not Yet Recruiting
14
Local Institution - 0033
Milan, Italy, 20141
Not Yet Recruiting
15
Local Institution - 0032
Milan, Italy, 20159
Not Yet Recruiting
16
Local Institution - 0042
Barcelona, Barcelona [Barcelona], Spain, 08035
Not Yet Recruiting
17
Local Institution - 0041
Avda.Pio XII 36,, Spain, 31008
Not Yet Recruiting
Research Team
B
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
CONTACT
F
First line of the email MUST contain NCT # and Site #.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
2
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