Actively Recruiting
A Study to Evaluate the Safety, Tolerability and Efficacy of RZ-001 With Valganciclovir (VGCV) in Subjects With Glioblastoma
Led by Rznomics, Inc. · Updated on 2025-09-05
43
Participants Needed
6
Research Sites
238 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a Phase 1/2a, open-label study to evaluate the safety, tolerability, immunogenicity, and preliminary clinical activity of RZ-001 administered in combination with VGCV in subjects with hTERT-positive GBM.
CONDITIONS
Official Title
A Study to Evaluate the Safety, Tolerability and Efficacy of RZ-001 With Valganciclovir (VGCV) in Subjects With Glioblastoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult males and females
- Histologically confirmed grade 4 astrocytoma or glioblastoma per 2021 WHO Classification of CNS Tumors
- Positive hTERT expression confirmed during screening
- ECOG performance status score of 2 or less
- Karnofsky Performance Status (KPS) of 60 or higher
- Life expectancy of at least 3 months
You will not qualify if you...
- Diagnosis of other malignant tumors within 5 years before RZ-001 administration
- Presence of extracranial metastases from tumor cells
- Current or past HIV positive status
- Deemed unsuitable for study participation by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 6 locations
1
The Catholic University of Korea, Incheon St. Mary's Hospital
Incheon, South Korea, 21431
Actively Recruiting
2
Gachon University Gil Medical Center
Incheon, South Korea, 21565
Actively Recruiting
3
Seoul National University Bundang Hospital
Seongnam-si, South Korea, 13620
Actively Recruiting
4
Severance Hospital, Yonsei University Health System
Seoul, South Korea, 03722
Actively Recruiting
5
Asan Medical Center
Seoul, South Korea, 05505
Actively Recruiting
6
Samsung Medical Center
Seoul, South Korea, 06351
Actively Recruiting
Research Team
R
Rznomics Inc.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
6
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