Actively Recruiting
A Study to Evaluate the Safety, Tolerability and Efficacy of RZ-001 in Combination With Valganciclovir (VGCV) and Atezolizumab/Bevacizumab in Subjects With Hepatocellular Carcinoma
Led by Rznomics, Inc. · Updated on 2025-07-29
45
Participants Needed
9
Research Sites
145 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is to evaluate the safety, tolerability, efficacy and immunogenicity of RZ-001 in combination with Valganciclovir (VGCV) and Atezolizumab/Bevacizumab when given to subjects with human telomerase reverse transcriptase (hTERT)-positive HCC.
CONDITIONS
Official Title
A Study to Evaluate the Safety, Tolerability and Efficacy of RZ-001 in Combination With Valganciclovir (VGCV) and Atezolizumab/Bevacizumab in Subjects With Hepatocellular Carcinoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult males and females
- Diagnosed with hepatocellular carcinoma at BCLC stage B or C
- Confirmed hTERT positive expression during screening
- ECOG performance status score of 0 or 1
- Child-Pugh liver function score of A
- Expected to live at least 3 months
You will not qualify if you...
- Moderate or severe ascites
- History of hepatic encephalopathy
- Presence of carcinomas other than hepatocellular carcinoma
- Current or past HIV positive status
- Deemed unsuitable for inclusion by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 9 locations
1
Pusan National University Yangsan Hospital
Busan, South Korea
Actively Recruiting
2
Kyungpook National University Hospital
Daegu, South Korea
Actively Recruiting
3
Catholic University of Korea, Seoul St. Mary's Hospital
Seoul, South Korea
Actively Recruiting
4
Gangnam Severance Hospital
Seoul, South Korea
Actively Recruiting
5
Kangbuk Samsung Medical Center
Seoul, South Korea
Actively Recruiting
6
Korea University Guro Hospital
Seoul, South Korea
Actively Recruiting
7
Samsung Medical Center
Seoul, South Korea
Actively Recruiting
8
Seoul National University Hospital
Seoul, South Korea
Actively Recruiting
9
Severance Hospital
Seoul, South Korea
Actively Recruiting
Research Team
R
Rznomics, Inc.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
3
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