Actively Recruiting
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MBX 4291 in Adult Participants With Obesity
Led by MBX Biosciences · Updated on 2026-04-28
124
Participants Needed
2
Research Sites
60 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate the safety and tolerability of single and multiple subcutaneous (SC) doses of MBX 4291 in adults with obesity.
CONDITIONS
Official Title
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MBX 4291 in Adult Participants With Obesity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age of >18 to 65 years at the time of signing the informed consent.
- Has a BMI of 630 to <50 kg/m2 at screening and baseline.
- Weight-stable, i.e., no more than �15% change in body weight for at least 3 months prior to screening and between screening and baseline.
You will not qualify if you...
- History of, or currently active, significant illness or medical disorders that in the opinion of the investigator may preclude participants from participating in the study.
- History of currently active pancreatitis, type I and type II diabetes.
- Secondary causes of obesity, including but not limited to hypothalamic, monogenic, syndromic, or endocrine causes.
- A personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
MBX Biosciences Investigational Site
Lexington, Kentucky, United States, 40509
Actively Recruiting
2
MBX Biosciences Investigational Site
Knoxville, Tennessee, United States, 37920
Actively Recruiting
Research Team
E
Elisa Fabbrini, MD, PhD
CONTACT
S
Stewart Hallett
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here