Actively Recruiting

Phase 1
Phase 2
Age: 18Years +
All Genders
NCT07291076

A Study to Evaluate the Safety and Tolerability of Pumitamig Alone or In Combination With Ipilimumab in Participants With First-Line Advanced or Unresectable Hepatocellular Carcinoma (HCC) (ROSETTA HCC-206)

Led by Bristol-Myers Squibb · Updated on 2026-05-14

129

Participants Needed

50

Research Sites

291 weeks

Total Duration

On this page

Sponsors

B

Bristol-Myers Squibb

Lead Sponsor

B

BioNTech SE

Collaborating Sponsor

AI-Summary

What this Trial Is About

The purpose of this study is to evaluate the safety and tolerability of Pumitamig alone or in combination with Ipilimumab in participants with first-line advanced or unresectable Hepatocellular Carcinoma (HCC)

CONDITIONS

Official Title

A Study to Evaluate the Safety and Tolerability of Pumitamig Alone or In Combination With Ipilimumab in Participants With First-Line Advanced or Unresectable Hepatocellular Carcinoma (HCC) (ROSETTA HCC-206)

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Have a confirmed diagnosis of locally advanced or unresectable Hepatocellular Carcinoma (HCC)
  • Have an ECOG performance status of 0 or 1
  • Have not received prior systemic therapy for advanced or unresectable HCC
  • Have measurable disease based on RECIST v1.1 criteria
Not Eligible

You will not qualify if you...

  • Have significant bleeding or clotting disorders or clear risk of bleeding
  • Have had an organ transplant
  • Have an autoimmune disease
  • Other protocol-defined exclusion criteria apply

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Trial Site Locations

Total: 50 locations

1

Local Institution - 0070

Los Angeles, California, United States, 90064

Not Yet Recruiting

2

Local Institution - 0107

Chicago, Illinois, United States, 60611

Not Yet Recruiting

3

John Theurer Cancer Center at Hackensack University Medical Center

Hackensack, New Jersey, United States, 07601-2191

Actively Recruiting

4

Local Institution - 0100

Mineola, New York, United States, 11501

Not Yet Recruiting

5

Providence Portland Medical Center

Portland, Oregon, United States, 97213

Actively Recruiting

6

Providence St. Vincent Medical Center

Portland, Oregon, United States, 97225

Actively Recruiting

7

Tennessee Oncology

Nashville, Tennessee, United States, 37203

Actively Recruiting

8

Vanderbilt University Medical Center

Nashville, Tennessee, United States, 37232

Actively Recruiting

9

Local Institution - 0083

Seattle, Washington, United States, 98109-1024

Not Yet Recruiting

10

Royal Prince Alfred Hospital

Camperdown, New South Wales, Australia, 2050

Actively Recruiting

11

Local Institution - 0033

Westmead, New South Wales, Australia, 2145

Not Yet Recruiting

12

Sunshine Coast University Hospital

Birtinya, Queensland, Australia, 4575

Actively Recruiting

13

The Royal Melbourne Hospital

Parkville, Victoria, Australia, 3052

Actively Recruiting

14

Bradfordhill

Santiago, Santiago Metropolitan, Chile, 8420383

Actively Recruiting

15

Local Institution - 0106

Santiago Region Metropolitana, Santiago Metropolitan, Chile, 8330034

Not Yet Recruiting

16

Local Institution - 0075

Guangzhou, Guangdong, China, 510515

Not Yet Recruiting

17

Local Institution - 0086

Xi'an, Shaanxi, China, 710126

Not Yet Recruiting

18

Local Institution - 0078

Shanghai, Shanghai Municipality, China, 200032

Not Yet Recruiting

19

Local Institution - 0056

Pessac, Aquitaine, France, 33600

Not Yet Recruiting

20

Local Institution - 0004

Grenoble, Isère, France, 38043

Not Yet Recruiting

21

Local Institution - 0001

Montpellier, Languedoc-Roussillon, France, 34295

Not Yet Recruiting

22

Local Institution - 0018

Saint Priest En Jarez, Pays de la Loire Region, France, 42270

Not Yet Recruiting

23

Local Institution - 0003

Bobigny, France, 93000

Not Yet Recruiting

24

Local Institution - 0031

Cologne, North Rhine-Westphalia, Germany, 50937

Not Yet Recruiting

25

Local Institution - 0028

Kiel, Schleswig-Holstein, Germany, 24105

Not Yet Recruiting

26

Local Institution - 0030

Frankfurt, Germany, D-60590

Not Yet Recruiting

27

Local Institution - 0109

Pisa, Tuscany, Italy, 56126

Not Yet Recruiting

28

Local Institution - 0088

Milan, Italy, 20

Not Yet Recruiting

29

Local Institution - 0089

Milan, Italy, 20132

Not Yet Recruiting

30

Local Institution - 0016

Pisa, Italy, 56126

Not Yet Recruiting

31

Local Institution - 0046

Rozzano (MI), Italy, 20089

Not Yet Recruiting

32

Local Institution - 0021

Wroclaw, Lower Silesian Voivodeship, Poland, 53-439

Not Yet Recruiting

33

Local Institution - 0105

Warsaw, Masovian Voivodeship, Poland, 02-106

Not Yet Recruiting

34

Local Institution - 0020

Gdansk, Poland, 80-952

Not Yet Recruiting

35

Local Institution - 0009

Singapore, Singapore, 119074

Not Yet Recruiting

36

Local Institution - 0012

Singapore, Singapore, 169610

Not Yet Recruiting

37

Local Institution - 0027

Seongnam-si, Gyeonggi-do, South Korea, 13496

Not Yet Recruiting

38

Local Institution - 0013

Seoul, Seoul Teugbyeolsi, South Korea, 06351

Not Yet Recruiting

39

Local Institution - 0011

Seoul, Seoul-teukbyeolsi, South Korea, 05505

Not Yet Recruiting

40

Local Institution - 0014

Pamplona, Navarre, Spain, 31008

Not Yet Recruiting

41

Local Institution - 0015

Barcelona, Spain, 8036

Not Yet Recruiting

42

Local Institution - 0060

Madrid, Spain, 28028

Not Yet Recruiting

43

Local Institution - 0095

Madrid, Spain, 28050

Not Yet Recruiting

44

Local Institution - 0032

Taichung, Taiwan, 404332

Not Yet Recruiting

45

National Cheng Kung University Hospital

Tainan, Taiwan, 704

Actively Recruiting

46

National Taiwan University Hospital

Taipei, Taiwan, 10002

Actively Recruiting

47

Taipei Veterans General Hospital

Taipei, Taiwan, 11217

Actively Recruiting

48

Hammersmith Hospital

London, London, City of, United Kingdom, W12 0HS

Actively Recruiting

49

Cancer Research UK - The Beatson Institute for Cancer Research (Cancer Research UK Beatson Laboratories)

Glasgow, South Western Scotland, United Kingdom, G611BD

Actively Recruiting

50

Local Institution - 0053

Metropolitan Borough of Wirral, United Kingdom, CH63 4JY

Not Yet Recruiting

Loading map...

Research Team

B

BMS Clinical Trials Contact Center www.BMSClinicalTrials.com

CONTACT

F

First line of the email MUST contain NCT # and Site #.

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

6

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here