Actively Recruiting
A Study to Evaluate Solrikitug in Participants With COPD (ZION)
Led by Uniquity One (UNI) · Updated on 2026-03-23
171
Participants Needed
118
Research Sites
115 weeks
Total Duration
On this page
Sponsors
U
Uniquity One (UNI)
Lead Sponsor
D
DevPro Biopharma
Collaborating Sponsor
AI-Summary
What this Trial Is About
A Randomized, Double-blind, Placebo-controlled, Multiple Dose-Ranging Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Solrikitug in Participants with Chronic Obstructive Pulmonary Disease (COPD).
CONDITIONS
Official Title
A Study to Evaluate Solrikitug in Participants With COPD (ZION)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- At least 40 years of age and no older than 75 years.
- Documented diagnosis of COPD for at least 12 months prior to Screening, defined by the GOLD Guidelines (2023), and elevated blood eosinophils at screening.
- At Screening FEV1/FVC ratio must be <0.70, and Post-bronchodilator FEV1 must be 40% to <80% predicted normal value calculated using Global Lung Function Initiative (GLI) reference equations (Cooper et al 2017).
- Symptomatic (COPD Assessment Test [CAT] Score 10) at Screening Visit 1.
- Participants must be on 2 or more inhaled maintenance medications for management of their COPD, for at least 3 months prior to screening.
You will not qualify if you...
- Female participant who is pregnant or breastfeeding.
- Participant has a known hypersensitivity to any component of the formulation of solrikitug, including any of the excipients, or a history of anaphylactic reaction to any therapeutic monoclonal antibody.
- Participant has history or evidence of any clinically significant cardiovascular, hematologic, hepatic, immunologic, metabolic, urologic, neurologic, dermatologic, psychiatric, renal and/or other major disease or malignancy, or any other condition that in the opinion of the Investigator or Medical Monitor might obfuscate the study data.
- Any other pulmonary disease than COPD that in the opinion of the Investigator, the severity of the disorder would impact the conduct of the study.
- Undergone major lung surgery, within 1 year of Screening Visit 1.
- Participant has a lower respiratory tract infection that required antibiotics within 6 weeks prior to Screening.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 118 locations
1
University of Alabama at Birmingham Hospital
Birmingham, Alabama, United States, 35294
Actively Recruiting
2
Syed Research Consultants
Sheffield, Alabama, United States, 35660
Actively Recruiting
3
Phoenix Medical Group
Peoria, Arizona, United States, 85381
Actively Recruiting
4
Epic Medical Research-Surprise
Sun City, Arizona, United States, 85351
Actively Recruiting
5
Alliance for Multispecialty Research
Tempe, Arizona, United States, 85281
Actively Recruiting
6
Novak Clinical Research
Tucson, Arizona, United States, 85741
Actively Recruiting
7
Antelope Valley Clinical Trials
Lancaster, California, United States, 93534
Actively Recruiting
8
Ark Clinical Research - Ballinger
Long Beach, California, United States, 90815
Actively Recruiting
9
Downtown LA Research Center, Inc.
Los Angeles, California, United States, 90017
Actively Recruiting
10
Newport Native MD, Inc.
Newport Beach, California, United States, 92663
Actively Recruiting
11
OM Research
Oxnard, California, United States, 93036
Actively Recruiting
12
Prospective Research Innovations, Inc.
Rancho Cucamonga, California, United States, 91730
Actively Recruiting
13
Velocity Clinical Research - Denver
Englewood, Colorado, United States, 80110
Actively Recruiting
14
Yale University School of Medicine
New Haven, Connecticut, United States, 06510
Withdrawn
15
Access Research Institute
Brooksville, Florida, United States, 34613
Actively Recruiting
16
Innovative Research of West Florida, Inc.
Clearwater, Florida, United States, 33756
Actively Recruiting
17
Clinical Research of West Florida - Clearwater
Clearwater, Florida, United States, 33765
Actively Recruiting
18
JY Research Institute
Cutler Bay, Florida, United States, 33189
Actively Recruiting
19
Hillcrest Medical Research, LLC
DeLand, Florida, United States, 32720
Actively Recruiting
20
North Florida Foundation for Research and Education
Gainesville, Florida, United States, 32608
Withdrawn
21
Direct Helper Research Center
Hialeah, Florida, United States, 33012
Actively Recruiting
22
Homestead Associates in Research Inc.
Homestead, Florida, United States, 33033
Actively Recruiting
23
AppleMed Research Group, LLC
Miami, Florida, United States, 33126
Actively Recruiting
24
Y&L Advanced Health Care, Inc.
Miami, Florida, United States, 33144
Actively Recruiting
25
Reliant Medical Research LLC
Miami, Florida, United States, 33165
Actively Recruiting
26
Valencia Medical & Research Center
Miami, Florida, United States, 33174
Actively Recruiting
27
De La Cruz Research Center, LLC
Miami, Florida, United States, 33184
Actively Recruiting
28
Coral Research Clinic Corporation
Miami, Florida, United States, 33186
Actively Recruiting
29
Pro-Care Research Center, Corp.
Miami Gardens, Florida, United States, 33014
Actively Recruiting
30
San Marcus Research Clinic, Inc.
Miami Lakes, Florida, United States, 33014
Actively Recruiting
31
Florida Institute for Clinical Research
Orlando, Florida, United States, 32825
Actively Recruiting
32
Sarasota Clinical Research
Sarasota, Florida, United States, 34239
Actively Recruiting
33
TBC Research
Tamarac, Florida, United States, 33321
Actively Recruiting
34
Clinical Research of West Florida - Tampa
Tampa, Florida, United States, 33606
Actively Recruiting
35
Appalachian Clinical Research, LLC
Adairsville, Georgia, United States, 30103
Actively Recruiting
36
Pulmonology, Sleep, Asthma, and Allergy Center - Dublin
Dublin, Georgia, United States, 31021
Completed
37
CPCC - Research, LLC
East Point, Georgia, United States, 30344
Actively Recruiting
38
Centricity Research
Rincon, Georgia, United States, 31326
Actively Recruiting
39
Velocity Clinical Research - Boise
Meridian, Idaho, United States, 83642
Completed
40
OSF HealthCare Saint Francis Medical Center
Peoria, Illinois, United States, 61606
Actively Recruiting
41
Indiana Medical Research Institute
Merrillville, Indiana, United States, 46410
Completed
42
The University of Kansas Medical Center
Kansas City, Kansas, United States, 66160
Withdrawn
43
The Research Group of Lexington, LLC
Lexington, Kentucky, United States, 40503
Completed
44
Tandem Clinical Research
Metairie, Louisiana, United States, 70006
Actively Recruiting
45
Care Access - Shreveport
Shreveport, Louisiana, United States, 71105
Actively Recruiting
46
Mayflower Clinical
South Dartmouth, Massachusetts, United States, 02747
Actively Recruiting
47
Revival Research Institute, LLC
Dearborn, Michigan, United States, 48126
Actively Recruiting
48
Henry Ford Health System
Detroit, Michigan, United States, 48207
Actively Recruiting
49
Pulmonary Research Institute of SE Michigan
Farmington Hills, Michigan, United States, 48336
Actively Recruiting
50
Revive Research Institute
Southfield, Michigan, United States, 48075
Actively Recruiting
51
Midwest Chest Consultants
Saint Charles, Missouri, United States, 63301
Not Yet Recruiting
52
Montana Medical Research, Inc.
Missoula, Montana, United States, 59808
Actively Recruiting
53
Henderson Trials
Henderson, Nevada, United States, 89052
Actively Recruiting
54
Rutgers, The State University of New Jersy
New Brunswick, New Jersey, United States, 08901
Actively Recruiting
55
Certified Research Associates Finger Lakes Medical Research, LLC
Cortland, New York, United States, 13045
Actively Recruiting
56
Corning Center for Clinical Research Smith Allergy & Asthma Specialists
Horseheads, New York, United States, 14845
Actively Recruiting
57
Northwell Health
New Hyde Park, New York, United States, 11042
Withdrawn
58
OnSite Clinical Solutions
Charlotte, North Carolina, United States, 28277
Actively Recruiting
59
Clinical Research of Gastonia
Gastonia, North Carolina, United States, 28054
Actively Recruiting
60
Triad Clinical Trials
Greensboro, North Carolina, United States, 27410
Actively Recruiting
61
Peters Medical Research
High Point, North Carolina, United States, 27260
Actively Recruiting
62
Advanced Respiratory and Sleep Medicine
Huntersville, North Carolina, United States, 28078
Actively Recruiting
63
Accellacare Wilmington
Wilmington, North Carolina, United States, 28401
Completed
64
Southeastern Research Center
Winston-Salem, North Carolina, United States, 27103
Actively Recruiting
65
MetroHealth Medical Center
Cleveland, Ohio, United States, 44109
Withdrawn
66
Remington Davis
Columbus, Ohio, United States, 43215
Actively Recruiting
67
NexGen Research
Lima, Ohio, United States, 45801
Actively Recruiting
68
OK Clinical Research
Edmond, Oklahoma, United States, 73034
Actively Recruiting
69
Velocity Clinical Research - Grants Pass
Grants Pass, Oregon, United States, 97257
Completed
70
Velocity Clinical Research - Medford
Medford, Oregon, United States, 97504
Actively Recruiting
71
Clinical Research Associates of Central PA
DuBois, Pennsylvania, United States, 15801
Actively Recruiting
72
Temple University
Philadelphia, Pennsylvania, United States, 19140
Actively Recruiting
73
University of Pittsburgh/UPMC
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
74
Allergy and Clinical Immunology Associates
Pittsburgh, Pennsylvania, United States, 15241
Actively Recruiting
75
AnMed Health
Anderson, South Carolina, United States, 29621
Actively Recruiting
76
Velocity Clinical Research - Anderson
Anderson, South Carolina, United States, 29621
Actively Recruiting
77
Medical University of South Carolina
Charleston, South Carolina, United States, 29245
Actively Recruiting
78
Velocity Clinical Research - Columbia
Columbia, South Carolina, United States, 29204
Actively Recruiting
79
Velocity Clinical Research - Gaffney
Gaffney, South Carolina, United States, 29340
Actively Recruiting
80
Velocity Clinical Research - Greenville
Greenville, South Carolina, United States, 29615
Completed
81
Clinical Research of Rock Hill
Rock Hill, South Carolina, United States, 29732
Actively Recruiting
82
Velocity Clinical Research - Spartanburg
Spartanburg, South Carolina, United States, 29303
Actively Recruiting
83
Velocity Clinical Research - Union
Union, South Carolina, United States, 29379
Actively Recruiting
84
Pulmonary & Sleep Specialists
Dickson, Tennessee, United States, 37055
Completed
85
Premier Research Center, LLC
Hendersonville, Tennessee, United States, 37075
Actively Recruiting
86
New Phase Research & Development
Knoxville, Tennessee, United States, 37909
Actively Recruiting
87
TTS Research
Boerne, Texas, United States, 78006
Not Yet Recruiting
88
Proactive RGV
Brownsville, Texas, United States, 78520
Actively Recruiting
89
Ten20 Clinical Research, LLC
Carrollton, Texas, United States, 75010
Actively Recruiting
90
IntraCare Health Center
Dallas, Texas, United States, 75254
Actively Recruiting
91
IntraCare Clinical
Greenville, Texas, United States, 75401
Actively Recruiting
92
Axsendo Clinical Research
Houston, Texas, United States, 77030
Completed
93
Gulf Coast Clinical Research
Houston, Texas, United States, 77070
Actively Recruiting
94
R & H Clinical Research
Katy, Texas, United States, 77494
Actively Recruiting
95
IntraCare Health Center
McKinney, Texas, United States, 75071
Actively Recruiting
96
SMS Clinical Research
Mesquite, Texas, United States, 75149
Actively Recruiting
97
ADP Clinical Research
Splendora, Texas, United States, 77372
Actively Recruiting
98
Alpine Research Organization, Inc.
Layton, Utah, United States, 84041
Actively Recruiting
99
Velocity Clinical Research - Hampton
Hampton, Virginia, United States, 23666
Actively Recruiting
100
Core Clinical
Everett, Washington, United States, 98201
Withdrawn
101
Confluence Health
Wenatchee, Washington, United States, 98801
Withdrawn
102
Momentum Taringa
Taringa, Brisbane, Australia, QLD 4068
Actively Recruiting
103
Northside Health
Coffs Harbour, New South Wales, Australia, 2450
Actively Recruiting
104
Momentum St. Leonards
Sydney, New South Wales, Australia, 2065
Actively Recruiting
105
Momentum Wellers Hill
Tarragindi, Queensland, Australia, 4121
Completed
106
Dr. Syed Anees Medicine Professional Corporation
Windsor, Ontario, Canada, N8X 5A6
Withdrawn
107
Pacific Clinical Research Network Auckland - PCRN West Auckland
New Lynn, Auckland, New Zealand, 0600
Actively Recruiting
108
Momentum Wellington
Mount Cook, Wellington Region, New Zealand, 6021
Actively Recruiting
109
Pacific Clinical Research Network Auckland - PCRN Auckland
Auckland, New Zealand, 1024
Actively Recruiting
110
New Zealand Respiratory & Sleep Institute (NZRSI)
Auckland, New Zealand, 1051
Actively Recruiting
111
Momentum Hawke's Bay
Hastings, New Zealand, 4122
Completed
112
Momentum Tauranga
Tauranga, New Zealand, 3110
Actively Recruiting
113
Momentum Kapiti
Waikanae, New Zealand, 5036
Actively Recruiting
114
The Medicines Evaluation Unit, an IQVIA business
Wythenshawe, Manchester, United Kingdom, M23 9QZGB
Actively Recruiting
115
Bradford Teaching Hospitals NHS Foundation Trust
Bradford, United Kingdom, BD9 6RJ
Actively Recruiting
116
Velocity Clinical Research High Wycombe
High Wycombe, United Kingdom, HP11 2QW
Actively Recruiting
117
Velocity Clinical Research - Bristol
London, United Kingdom, N12 8BU
Actively Recruiting
118
Queen Anne Street Medical Centre
London, United Kingdom, W1T 6AH
Actively Recruiting
Research Team
U
Uniquity One Clinical Trials
CONTACT
A
Anushri Walsh
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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