Actively Recruiting
A Study to Evaluate TAR-210 Versus Single Agent Intravesical Cancer Treatment in Participants With Bladder Cancer
Led by Janssen Research & Development, LLC · Updated on 2026-05-08
641
Participants Needed
193
Research Sites
454 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The main purpose of this study is to compare the disease-free survival between participants receiving treatment with TAR-210 versus investigator's choice of intravesical chemotherapy for treatment of intermediate-risk NMIBC.
CONDITIONS
Official Title
A Study to Evaluate TAR-210 Versus Single Agent Intravesical Cancer Treatment in Participants With Bladder Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically confirmed diagnosis of intermediate-risk non-muscle invasive bladder cancer within 90 days before randomization
- Must meet at least one of the following: Ta low grade/Grade 1 primary or recurrent, Ta low grade/Grade 2 primary or recurrent with at least one risk factor such as multiple tumors, tumor size ≥3 cm, early recurrence, frequent recurrence, or recurrence after prior adjuvant intravesical treatment
- Presence of a susceptible FGFR mutation or fusion confirmed by urine or tumor tissue testing
- Willingness to undergo all study procedures including multiple cystoscopies and TURBT assessments
- Visible papillary disease must be fully resected before randomization with no disease detected on screening cystoscopy
- Prior or concurrent second malignancy allowed if unlikely to affect safety or efficacy assessments
- Eastern Cooperative Oncology Group performance status of 0 to 2
You will not qualify if you...
- Allergies or intolerance to Erdafitinib excipients, TAR-210 drug delivery system materials, urinary catheter materials, MMC, or Gemcitabine
- Anatomical bladder or urethral abnormalities that may prevent safe catheter use or TAR-210 insertion
- Polyuria with 24-hour urine volume exceeding 4000 milliliters
- Current use of indwelling urinary catheters (intermittent catheterization allowed)
- Major surgery or significant injury within 4 weeks prior to first dose (excluding TURBT)
- For substudy participants, prior diagnosis of urothelial bladder carcinoma before current diagnosis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 193 locations
1
Arkansas Urology
Little Rock, Arkansas, United States, 72211
Completed
2
Genesis Research LLC
Los Alamitos, California, United States, 90720
Active, Not Recruiting
3
USC Norris Comprehensive Cancer Center
Los Angeles, California, United States, 90033
Active, Not Recruiting
4
University of California Irvine Medical Center
Orange, California, United States, 92868
Active, Not Recruiting
5
Om Research LLC
San Diego, California, United States, 92123
Active, Not Recruiting
6
Genesis Research LLC 1
Sherman Oaks, California, United States, 91411
Completed
7
University of Colorado Cancer Center Anschultz Cancer Pavilion
Aurora, Colorado, United States, 80045
Completed
8
Colorado Clinical Research
Lakewood, Colorado, United States, 80228
Active, Not Recruiting
9
Moffitt Cancer Center
Tampa, Florida, United States, 33612
Active, Not Recruiting
10
Northwestern University
Chicago, Illinois, United States, 60611
Completed
11
First Urology
Jeffersonville, Indiana, United States, 47130
Completed
12
Wichita Urology Group
Wichita, Kansas, United States, 67226
Active, Not Recruiting
13
Ochsner Health System
New Orleans, Louisiana, United States, 70121-2429
Active, Not Recruiting
14
Chesapeake Urology Research Associates
Hanover, Maryland, United States, 21076
Completed
15
Brigham And Women's Hospital
Boston, Massachusetts, United States, 02115
Completed
16
Karmanos Cancer Institute
Detroit, Michigan, United States, 48201
Active, Not Recruiting
17
Comprehensive Urology
Royal Oak, Michigan, United States, 48073
Active, Not Recruiting
18
Mercy Research
St Louis, Missouri, United States, 63141
Completed
19
Specialty Clinical Research of St Louis
St Louis, Missouri, United States, 63141
Active, Not Recruiting
20
The Urology Center, PC
Omaha, Nebraska, United States, 68114
Active, Not Recruiting
21
Cancer Institute Of New Jersey
New Brunswick, New Jersey, United States, 08901
Active, Not Recruiting
22
Integrated Medical Professionals
New York, New York, United States, 10016
Completed
23
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Active, Not Recruiting
24
Associated Medical Professionals of Ny
Syracuse, New York, United States, 13210
Active, Not Recruiting
25
SUNY Upstate Med Univ
Syracuse, New York, United States, 13210
Active, Not Recruiting
26
Levine Cancer Institute
Charlotte, North Carolina, United States, 28204
Active, Not Recruiting
27
Associated Urologists of North Carolina
Raleigh, North Carolina, United States, 27612
Active, Not Recruiting
28
MidLantic Urology
Bala-Cynwyd, Pennsylvania, United States, 19004
Active, Not Recruiting
29
Keystone Urology Specialists
Lancaster, Pennsylvania, United States, 17604
Active, Not Recruiting
30
Carolina Urologic Research Center
Myrtle Beach, South Carolina, United States, 29572
Active, Not Recruiting
31
The Conrad Pearson Clinic
Germantown, Tennessee, United States, 38138
Active, Not Recruiting
32
University of Tennessee Medical Center
Knoxville, Tennessee, United States, 37920
Completed
33
Urology Associates
Nashville, Tennessee, United States, 37209
Active, Not Recruiting
34
Urology Austin
Austin, Texas, United States, 78745
Active, Not Recruiting
35
Urology Clinics of North Texas
Dallas, Texas, United States, 75231
Active, Not Recruiting
36
UT Southwestern
Dallas, Texas, United States, 75390
Completed
37
Houston Metro Urology
Houston, Texas, United States, 77027
Active, Not Recruiting
38
Spokane Urology
Spokane, Washington, United States, 99202
Active, Not Recruiting
39
Hospital Sirio Libanes
Buenos Aires, Argentina, C1419AHN
Active, Not Recruiting
40
Investigaciones Clinico Moleculares (ICM)
CABA, Argentina, C1425
Active, Not Recruiting
41
Cemaic Centro Privado de Especialidades Medicas Ambulatorias e Investigacion Clinica
Córdoba, Argentina, 5000
Active, Not Recruiting
42
Centro Urologico Profesor Bengio
Córdoba, Argentina, X5000KPH
Active, Not Recruiting
43
Hospital Privado de la Comunidad
Mar del Plata, Argentina, B7602
Active, Not Recruiting
44
Sanatorio de la Mujer
Rosario, Argentina, 2000
Active, Not Recruiting
45
Medizinische Universitaet Graz
Graz, Austria, 8036
Actively Recruiting
46
Medizinische Universitat Innsbruck
Innsbruck, Austria, 6020
Actively Recruiting
47
Ordensklinikum Linz GmbH Elisabethinen
Linz, Austria, 4020
Actively Recruiting
48
Universitaetsklinikum Salzburg Landeskrankenhaus
Salzburg, Austria, 5020
Actively Recruiting
49
Medical University Vienna MUV
Vienna, Austria, 1090
Actively Recruiting
50
AZORG campus Aalst Moorselbaan
Aalst, Belgium, 9300
Actively Recruiting
51
AZ Sint-Jan
Bruges, Belgium, 8000
Actively Recruiting
52
UZ Antwerpen
Edegem, Belgium, 2650
Completed
53
AZ Maria Middelares
Ghent, Belgium, 9000
Actively Recruiting
54
Universitair Ziekenhuis Gasthuisberg
Leuven, Belgium, 3000
Active, Not Recruiting
55
Vitaz
Sint-Niklaas, Belgium, 9100
Actively Recruiting
56
CHU UCL Namur - Site Godinne
Yvoir, Belgium, 5530
Actively Recruiting
57
Fundacao Pio XII
Barretos, Brazil, 14780-070
Active, Not Recruiting
58
Universidade Estadual De Campinas
Campinas, Brazil, 13083-888
Completed
59
Liga Norte Riograndense Contra O Cancer
Natal, Brazil, 59062 000
Active, Not Recruiting
60
Associacao Hospitalar Moinhos de Vento
Porto Alegre, Brazil, 90035-001
Active, Not Recruiting
61
Irmandade da Santa Casa de Misericordia de Porto Alegre
Porto Alegre, Brazil, 90050170
Active, Not Recruiting
62
HBA SA Assitencia Medica e Hospitalar
Salvador, Brazil, 41810-011
Active, Not Recruiting
63
Fundacao do ABC Centro Universitario FMABC
Santo André, Brazil, 09060 870
Active, Not Recruiting
64
Irmandade Da Santa Casa De Misericordia De Sao Paulo
São Paulo, Brazil, 01221-020
Active, Not Recruiting
65
Fundacao Faculdade de Medicina - Instituto do Cancer do Estado de Sao Paulo
São Paulo, Brazil, 01246-000
Active, Not Recruiting
66
Real e Benemérita Associação Portuguesa de Beneficência
São Paulo, Brazil, 01323 900
Active, Not Recruiting
67
Fundacao Antonio Prudente A C Camargo Cancer Center
São Paulo, Brazil, 01509 900
Completed
68
Beijing Friendship Hospital Capital Medical University
Beijing, China, 100050
Active, Not Recruiting
69
Peking University Third Hospital
Beijing, China, 100191
Active, Not Recruiting
70
Hunan Cancer hospital
Changsha, China, 410013
Active, Not Recruiting
71
The Third People's Hospital of Chengdu
Cheng Du Shi, China, 610014
Active, Not Recruiting
72
West China School of Medicine/West China Hospital, Sichuan University
Cheng Du Shi, China, 610041
Active, Not Recruiting
73
Chongqing Cancer Hospital
Chongqing, China, 400033
Active, Not Recruiting
74
Fujian Medical University Union Hospital
Fuzhou, China, 350001
Active, Not Recruiting
75
Sun Yat Sen University Cancer Center
Guangzhou, China, 510060
Active, Not Recruiting
76
Nanjing Drum Tower Hospital
Nanjing, China, 210008
Active, Not Recruiting
77
Zhongda Hospital Southeast University
Nanjing, China, 210009
Active, Not Recruiting
78
Huadong Hospital Affiliated to Fudan University
Shanghai, China, 200031
Active, Not Recruiting
79
The Second Hospital Of Tianjin Medical University
Tianjin, China, 300061
Active, Not Recruiting
80
Cancer Hospital of Xinjiang Medical University
Ürümqi, China, 830011
Active, Not Recruiting
81
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, China, 325000
Active, Not Recruiting
82
Tongji Hospital Tongji Medical College of Huazhong University of Science and Technology
Wuhan, China, 430032
Active, Not Recruiting
83
The First Affiliated Hospital of Xian Jiaotong University
Xi'an, China, 710063
Active, Not Recruiting
84
The Affiliated Hospital of Xuzhou Medical University
Xuzhou, China, 221004
Active, Not Recruiting
85
Fakultni nemocnice Hradec Kralove
Hradec Králové, Czechia, 500 05
Completed
86
Fakultni nemocnice Olomouc
Olomouc, Czechia, 779 00
Actively Recruiting
87
Vseobecna fakultni nemocnice v Praze
Prague, Czechia, 128 08
Actively Recruiting
88
Fakultni Thomayerova nemocnice
Prague, Czechia, 140 59
Actively Recruiting
89
Fakultni nemocnice v Motole
Prague, Czechia, 150 06
Actively Recruiting
90
Aarhus University Hospital
Aarhus, Denmark, 8200
Actively Recruiting
91
Rigshospitalet
Copenhagen, Denmark, 2100
Actively Recruiting
92
Herlev Hospital
Herlev, Denmark, 2730
Actively Recruiting
93
Odense Universitetshospital
Odense, Denmark, 5000
Actively Recruiting
94
Zealand University Hospital
Roskilde, Denmark, 4000
Actively Recruiting
95
Hospital Center University De Lille
Lille, France, 59000
Completed
96
Polyclinique de Limoges - Francois Chenieux
Limoges, France, 87000
Actively Recruiting
97
Hôpital Edouard Herriot
Lyon, France, 69003
Actively Recruiting
98
Institut Paoli Calmettes
Marseille, France, 13009
Actively Recruiting
99
Hopital Saint Louis
Paris, France, 75010
Actively Recruiting
100
CHU Pitie Salpetriere
Paris, France, 75013
Actively Recruiting
101
APHP - Hopital Bichat - Claude Bernard
Paris, France, 75018
Actively Recruiting
102
Clinique de la Croix du Sud
Quint-Fonsegrives, France, 31130
Actively Recruiting
103
Chu Rennes Hopital Pontchaillou
Rennes, France, 35000
Completed
104
CHU Rangueil
Toulouse, France, 31059
Actively Recruiting
105
Institut Gustave Roussy
Villejuif, France, 94805
Actively Recruiting
106
Charite - Universitaetsmedizin Berlin (CCM)
Berlin, Germany, 10117
Active, Not Recruiting
107
Stadtisches Klinikum Braunschweig gGmbH-Klinik fur Urologie und Uroonkologie
Braunschweig, Germany, 38126
Actively Recruiting
108
Studienzentrum Bayenthal
Cologne, Germany, 50968
Actively Recruiting
109
Urologische Gemeinschaftspraxis
Dresden, Germany, 01307
Completed
110
Universitaetsklinikum Frankfurt
Frankfurt am Main, Germany, 60596
Actively Recruiting
111
Urologikum Hamburg MVZ - Germany
Hamburg, Germany, 22081
Active, Not Recruiting
112
Marien hospital Herne
Herne, Germany, 44625
Actively Recruiting
113
Universitatsklinikum Jena
Jena, Germany, 07747
Active, Not Recruiting
114
Klinikum rechts der Isar an der Technischen Universitat Munchen
München, Germany, 81675
Completed
115
Klinikum St. Elisabeth Straubing GmbH
Straubing, Germany, 94315
Actively Recruiting
116
Katharinenhospital Innere Medizin
Stuttgart, Germany, 70174
Completed
117
Prince Of Wales Hospital
Hong Kong, Hong Kong
Active, Not Recruiting
118
Queen Mary Hospital
Hong Kong, Hong Kong
Active, Not Recruiting
119
Cork University Hospital
Cork, Ireland, T12 DC4A
Active, Not Recruiting
120
Mater Misericordiae University Hospital
Dublin, Ireland, D07 A8NN
Active, Not Recruiting
121
Mater Private Hospital
Dublin, Ireland, D07 WKW8
Active, Not Recruiting
122
Adelaide and Meath Hospital
Dublin, Ireland, D24 NR0A
Active, Not Recruiting
123
Rambam Health Care Campus
Haifa, Israel, 3109601
Actively Recruiting
124
Hadassah University Hospita Ein Kerem
Jerusalem, Israel, 9112001
Completed
125
Sheba Medical Center
Ramat Gan, Israel, 5262000
Actively Recruiting
126
Ziv Medical Center
Safed, Israel, 13100
Actively Recruiting
127
Sourasky Medical Center
Tel Aviv, Israel, 6423906
Actively Recruiting
128
Ospedale S. Donato Arezzo, USL 8 - U.O. Oncologia Medica
Arezzo, Italy, 52100
Actively Recruiting
129
Cliniche Humanitas Gavazzeni
Bergamo, Italy, 24125
Actively Recruiting
130
ASST Spedali Civili Brescia
Brescia, Italy, 25123
Actively Recruiting
131
Ospedale San Raffaele
Milan, Italy, 20132
Completed
132
Istituto Dei Tumori Di Milano
Milan, Italy, 20133
Actively Recruiting
133
Universita Campus Bio-Medico di Roma
Roma, Italy, 00128
Actively Recruiting
134
Istituto Nazionale Tumori Regina Elena
Roma, Italy, 00144
Actively Recruiting
135
Istituto Clinico Humanitas
Rozzano, Italy, 20089
Actively Recruiting
136
A.O.Citta della Salute e della Scienza di Torino
Torino, Italy, 10126
Actively Recruiting
137
Hyogo Prefectural Amagasaki General Medical Center
Amagasaki Shi, Japan, 660 8550
Active, Not Recruiting
138
St Marianna University Hospital
Kawasaki Shi, Japan, 216 8511
Actively Recruiting
139
Kobe City Medical Center General Hospital
Kobe, Japan, 650 0047
Active, Not Recruiting
140
National Hospital Organization Kumamoto Medical Center
Kumamoto, Japan, 860 0008
Active, Not Recruiting
141
Osaka International Cancer Institute
Osaka, Japan, 541 8567
Actively Recruiting
142
Gunma Prefectural Cancer Center
Ōta-ku, Japan, 373 8550
Actively Recruiting
143
Saitama Medical Center
Saitama, Japan, 350 8550
Active, Not Recruiting
144
JRC Wakayama Medical Center
Wakayama, Japan, 640 8558
Active, Not Recruiting
145
Yokohama Municipal Citizen's Hospital
Yokohama, Japan, 221 0855
Actively Recruiting
146
Yokohama City University Medical Center
Yokohama, Japan, 232 0024
Active, Not Recruiting
147
Yokosuka Kyosai Hospital
Yokosuka, Japan, 238 8558
Actively Recruiting
148
Uniwersytecki Szpital Kliniczny w Bialymstoku
Bialystok, Poland, 15 276
Actively Recruiting
149
IN VIVO Sp. z o.o
Bydgoszcz, Poland, 85 048
Actively Recruiting
150
Centrum Onkologii im Prof F Lukaszczyka w Bydgoszczy
Bydgoszcz, Poland, 85 796
Completed
151
Uniwersytecki Szpital Kliniczny nr 4
Lublin, Poland, 20 090
Actively Recruiting
152
Wojewodzki Szpital im Sw Ojca Pio w Przemyslu
Przemyśl, Poland, 37 700
Active, Not Recruiting
153
Szpital Wojewodzki Im Sw Lukasza Samodzielny Publiczny Zaklad Opieki Zdrowotnej W Tarnowie
Tarnów, Poland, 33-100
Actively Recruiting
154
Medicover Integrated Clinical Services Sp z o o
Torun, Poland, 87-100
Completed
155
Mazowiecki Szpital Onkologiczny Sp z o o
Wieliszew, Poland, 05-135
Actively Recruiting
156
4 Wojskowy Szpital Kliniczny Z Poliklinika Samodzielny Publiczny Zaklad Opieki Zdrowotnej We Wroclawiu
Wroclaw, Poland, 50 981
Completed
157
Dolnoslaskie Centrum Onkologii Pulmonologii i Hematologii
Wroclaw, Poland, 53-413
Actively Recruiting
158
Chungbuk National University Hospital
Chungcheongbuk Do, South Korea, 28644
Completed
159
National Cancer Center
Gyeonggi-do, South Korea, 10408
Actively Recruiting
160
Chonnam National University Hwasun Hospital
Jeollanam-do, South Korea, 58128
Actively Recruiting
161
Samsung Medical Center
Seoul, South Korea, 06351
Actively Recruiting
162
The Catholic University of Korea Seoul St Marys Hospital
Seoul, South Korea, 06591
Active, Not Recruiting
163
Seoul National University Hospital
Seoul, South Korea, 3080
Actively Recruiting
164
Hosp Univ A Coruna
A Coruña, Spain, 15006
Actively Recruiting
165
Hosp. Univ. de La Ribera
Alzira, Spain, 46600
Actively Recruiting
166
Fund. Puigvert
Barcelona, Spain, 08025
Actively Recruiting
167
Hosp Univ Vall D Hebron
Barcelona, Spain, 08035
Completed
168
Hosp Clinic de Barcelona
Barcelona, Spain, 08036
Actively Recruiting
169
Hosp. Puerta Del Mar
Cadiz, Spain, 11009
Actively Recruiting
170
Hosp. Gral. Univ. de Castellon
Castellon, Spain, 12004
Actively Recruiting
171
Hosp. de Jerez de La Frontera
Jerez de la Frontera, Spain, 11407
Actively Recruiting
172
Hosp. Gral. Univ. Gregorio Maranon
Madrid, Spain, 28007
Completed
173
Clinica Univ. de Navarra
Madrid, Spain, 28027
Actively Recruiting
174
Hosp. Univ. 12 de Octubre
Madrid, Spain, 28041
Actively Recruiting
175
Hosp Virgen de La Victoria
Málaga, Spain, 29010
Actively Recruiting
176
Hosp. Univ. Central de Asturias
Oviedo, Spain, 33011
Completed
177
Hosp.Univ.Parc Tauli
Sabadell, Spain, 08208
Actively Recruiting
178
Hosp. Virgen Del Rocio
Seville, Spain, 41013
Completed
179
Hosp. Clinico Univ. de Valencia
Valencia, Spain, 46010
Actively Recruiting
180
Adana Baskent Practice and Research Hospital
Adana, Turkey (Türkiye), 01120
Completed
181
Ankara University Medical Faculty
Ankara, Turkey (Türkiye), 06100
Completed
182
Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital
Ankara, Turkey (Türkiye), 06200
Actively Recruiting
183
Istanbul University Cerrahpasa Medical Faculty
Istanbul, Turkey (Türkiye), 34153
Completed
184
T C Saglik Bakanlıgi Goztepe Prof Dr Suleyman Yalcın Sehir Hastanesi
Istanbul, Turkey (Türkiye), 34722
Actively Recruiting
185
Kartal Dr Lutfi Kirdar sehir Hastanesi
Istanbul, Turkey (Türkiye), 34865
Actively Recruiting
186
Dokuz Eylul University Medical Faculty
Izmir, Turkey (Türkiye), 35330
Actively Recruiting
187
Southmead Hospital
Bristol, United Kingdom, BS105NB
Actively Recruiting
188
St Bartholomews Hospital
London, United Kingdom, EC1A 7BE
Actively Recruiting
189
Charing Cross Hospital
London, United Kingdom, W6 8RF
Actively Recruiting
190
Newcastle Freeman Hospital
Newcastle upon Tyne, United Kingdom, NE7 7DN
Actively Recruiting
191
Sheffield Teaching Hospitals NHS Foundation Trust
Sheffield, United Kingdom, S10 2SJ
Actively Recruiting
192
Southampton General Hospital
Southampton, United Kingdom, SO16 6YD
Actively Recruiting
193
Royal Marsden Hospital
Sutton, United Kingdom, SM2 5PT
Actively Recruiting
Research Team
S
Study Contact
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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