Actively Recruiting
This Study Evaluates the Clinical Effect of Adding Spermidine Gel to Minimally Invasive Non-surgical Periodontal Therapy (MINST) to Improve Periodontal Health.
Led by Luca Ramaglia · Updated on 2025-02-26
12
Participants Needed
1
Research Sites
51 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study investigates the effectiveness of using a spermidine-based gel as an adjunct to minimally invasive non-surgical periodontal therapy (MINST) for treating periodontitis. The primary outcome is to assess whether the addition of spermidine gel reduces pocket depth (PPD) compared to MINST alone. Secondary outcome include evaluating other periodontal parameters like bleeding on probing, FMBS and FMPS and CAL over a 12-month period.
CONDITIONS
Official Title
This Study Evaluates the Clinical Effect of Adding Spermidine Gel to Minimally Invasive Non-surgical Periodontal Therapy (MINST) to Improve Periodontal Health.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Untreated periodontitis with at least 2 sites showing clinical attachment loss greater than 2 mm and probing depth greater than 4 mm
- Voluntary signing of informed consent
You will not qualify if you...
- Presence of systemic diseases such as diabetes mellitus, cardiovascular, renal, hepatic, or pulmonary conditions
- Smoking 10 or more cigarettes per day
- Pregnancy or breastfeeding
- Allergy to any ingredients used in the study products
- Diseases affecting bone and/or connective tissue metabolism
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
AOU Federico II
Naples, Italy, Italy, 80013
Actively Recruiting
Research Team
L
Luca Ramaglia, Professor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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