Actively Recruiting
A Study Evaluating Anvumetostat in Combination With Other Therapies in Participants With Advanced Gastrointestinal, Biliary Tract, or Pancreatic Cancers With Homozygous Methylthioadenosine Phosphorylase (MTAP)-Deletion (MTAPESTRY 103)
Led by Amgen · Updated on 2026-03-31
350
Participants Needed
77
Research Sites
247 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The study aims to determine maximum tolerated dose (MTD) or recommended combination dose of the MTA-cooperative PRMT5 inhibitor Anvumetostat administered in combination with other therapies in adult participants with metastatic or locally advanced methylthioadenosine phosphorylase (MTAP)-deleted gastrointestinal, biliary tract, or pancreatic cancers. The study also aims to determine the safety profile of Anvumetostat administered in combination with other therapies in adult participants with metastatic or locally advanced MTAP-deleted gastrointestinal, biliary tract, or pancreatic cancers.
CONDITIONS
Official Title
A Study Evaluating Anvumetostat in Combination With Other Therapies in Participants With Advanced Gastrointestinal, Biliary Tract, or Pancreatic Cancers With Homozygous Methylthioadenosine Phosphorylase (MTAP)-Deletion (MTAPESTRY 103)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older (or legal adult age in country if higher)
- Histologically or cytologically confirmed metastatic and/or unresectable (locally advanced) pancreatic adenocarcinoma
- Available tumor tissue sample or willingness to undergo tumor biopsy before dosing
- Confirmed homozygous MTAP-deletion
- Measurable disease as defined by RECIST v1.1
- Adequate organ function as defined in the study protocol
- For Subprotocol C: presence of RAS mutation and at least one prior systemic therapy for advanced or metastatic pancreatic ductal adenocarcinoma
You will not qualify if you...
- Prior treatment with MAT2A inhibitors, PRMT5 inhibitors, or MAPK pathway inhibitors including KRAS inhibitors (for Subprotocol C)
- Radiation therapy within 28 days before first dose
- Major surgery within 28 days before first dose of Anvumetostat
- Cardiovascular and pulmonary conditions as defined in the protocol
- Gastrointestinal tract disorders causing inability to take oral medication, malabsorption syndrome, need for IV alimentation, gastric/jejunal tube feeding, or uncontrolled inflammatory gastrointestinal diseases such as Crohn's disease or ulcerative colitis
- History of solid organ transplantation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 77 locations
1
Comprehensive Blood and Cancer Center
Bakersfield, California, United States, 93309
Actively Recruiting
2
City of Hope National Medical Center
Duarte, California, United States, 91010
Actively Recruiting
3
City of Hope Orange County Lennar Foundation Cancer Center
Duarte, California, United States, 91010
Actively Recruiting
4
University of California San Diego Moores Cancer Center
La Jolla, California, United States, 92093
Actively Recruiting
5
Translational Research in Oncology US Inc, Trio Central Pharmacy
Los Angeles, California, United States, 90095
Actively Recruiting
6
University of California Los Angeles
Santa Monica, California, United States, 90404
Actively Recruiting
7
Rocky Mountain Cancer Centers
Aurora, Colorado, United States, 80012
Actively Recruiting
8
Hartford Hospital
Hartford, Connecticut, United States, 06106
Actively Recruiting
9
Yale University
New Haven, Connecticut, United States, 06520
Actively Recruiting
10
Norwalk Hospital
Norwalk, Connecticut, United States, 06856
Actively Recruiting
11
University of Chicago
Chicago, Illinois, United States, 60637
Actively Recruiting
12
Indiana University
Indianapolis, Indiana, United States, 46202
Actively Recruiting
13
Norton Cancer Institute
Louisville, Kentucky, United States, 40202
Actively Recruiting
14
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215
Actively Recruiting
15
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02215
Actively Recruiting
16
Washington University
St Louis, Missouri, United States, 63110
Actively Recruiting
17
University of Nebraska
Omaha, Nebraska, United States, 68198
Actively Recruiting
18
Comprehensive Cancer Centers of Nevada
Las Vegas, Nevada, United States, 89169
Terminated
19
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
20
Duke University
Durham, North Carolina, United States, 27710
Actively Recruiting
21
Cleveland Clinic Foundation
Cleveland, Ohio, United States, 44195
Actively Recruiting
22
United States Oncology Regulatory Affairs Corporate Office
Nashville, Tennessee, United States, 37203
Actively Recruiting
23
Oncology Consultants Cancer Center
Houston, Texas, United States, 77030
Terminated
24
US Oncology Research Investigational Products Center
Irving, Texas, United States, 75063
Actively Recruiting
25
University of Virginia Cancer Center
Charlottesville, Virginia, United States, 22903
Actively Recruiting
26
Virginia Cancer Specialists PC
Fairfax, Virginia, United States, 22031
Actively Recruiting
27
Fred Hutchinson Cancer Center
Seattle, Washington, United States, 98106
Actively Recruiting
28
Northwest Medical Specialties, PLLC
Tacoma, Washington, United States, 98405
Actively Recruiting
29
Northwest Cancer Specialists - Vancouver
Vancouver, Washington, United States, 98684
Completed
30
Chris OBrien Lifehouse
Camperdown, New South Wales, Australia, 2050
Actively Recruiting
31
GenesisCare -North Shore Oncology
St Leonards, New South Wales, Australia, 2065
Actively Recruiting
32
The Queen Elizabeth Hospital
Woodville South, South Australia, Australia, 5011
Actively Recruiting
33
Austin Health, Austin Hospital
Heidelberg, Victoria, Australia, 3084
Actively Recruiting
34
Peter MacCallum Cancer Centre
Melbourne, Victoria, Australia, 3000
Actively Recruiting
35
Epworth Healthcare
St Albans, Victoria, Australia, 3021
Actively Recruiting
36
Universite Catholique de Louvain Cliniques Universitaires Saint Luc
Brussels, Belgium, 1200
Actively Recruiting
37
Universitair Ziekenhuis Antwerpen
Edegem, Belgium, 2650
Actively Recruiting
38
Universitair Ziekenhuis Leuven - Campus Gasthuisberg
Leuven, Belgium, 3000
Actively Recruiting
39
Arthur J E Child Comprehensive Cancer Centre
Calgary, Alberta, Canada, T2N 5G2
Actively Recruiting
40
Princess Margaret Cancer Centre
Toronto, Ontario, Canada, M5G 1Z5
Actively Recruiting
41
CHU de Quebec Hopital de l Enfant Jesus
Québec, Quebec, Canada, G1J 1Z4
Actively Recruiting
42
Mengchao Hepatobiliary Hospital of Fujian Medical University
Fuzhou, Fujian, China, 350028
Actively Recruiting
43
Sun Yat-Sen University Cancer Center
Guangzhou, Guangdong, China, 510030
Actively Recruiting
44
Harbin Medical University Cancer Hospital
Harbin, Heilongjiang, China, 150000
Actively Recruiting
45
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China, 450052
Actively Recruiting
46
Union Hospital Tongji Medical College Huazhong University of Science and Technology
Wuhan, Hubei, China, 430022
Actively Recruiting
47
The First Bethune Hospital of Jilin University
Changchun, Jilin, China, 130021
Actively Recruiting
48
Herlev og Gentofte Hospital
Herlev, Denmark, 2730
Actively Recruiting
49
Institut Bergonie
Bordeaux, France, 33000
Actively Recruiting
50
Centre Georges Francois Leclerc
Dijon, France, 21000
Actively Recruiting
51
Institut Paoli Calmettes
Marseille, France, 13009
Actively Recruiting
52
Gustave Roussy
Villejuif, France, 94805
Actively Recruiting
53
Universitaetsklinikum Essen
Essen, Germany, 45147
Actively Recruiting
54
Universitaetsklinikum Heidelberg
Heidelberg, Germany, 69120
Actively Recruiting
55
Universitaetsklinikum Wuerzburg
Würzburg, Germany, 97078
Actively Recruiting
56
Alexandra Hospital
Athens, Greece, 11528
Actively Recruiting
57
General Hospital Of Thessaloniki Papageorgiou
Thessaloniki, Greece, 56429
Actively Recruiting
58
European Interbalkan Medical Center
Thessaloniki, Greece, 57001
Actively Recruiting
59
Queen Mary Hospital, The University of Hong Kong
Hong Kong, Hong Kong
Actively Recruiting
60
Prince of Wales Hospital, Chinese University of Hong Kong
Shatin, New Territories, Hong Kong
Actively Recruiting
61
Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, Italy, 20133
Actively Recruiting
62
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
Milan, Italy, 20162
Actively Recruiting
63
IRCCS Istituto Clinico Humanitas
Rozzano MI, Italy, 20089
Actively Recruiting
64
Centro Ricerche Cliniche Di Verona Societa responsabilita limitata
Verona, Italy, 37134
Actively Recruiting
65
Aichi Cancer Center
Nagoya, Aichi-ken, Japan, 464-8681
Actively Recruiting
66
National Cancer Center Hospital East
Kashiwa-shi, Chiba, Japan, 277-8577
Actively Recruiting
67
Kanagawa Prefectural Hospital Organization Kanagawa Cancer Center
Yokohama, Kanagawa, Japan, 241-8515
Actively Recruiting
68
National Cancer Center Hospital
Chuo-ku, Tokyo, Japan, 104-0045
Actively Recruiting
69
Radboud Universitair Medisch Centrum
Nijmegen, Netherlands, 6525 GA
Actively Recruiting
70
Hospital Universitario Virgen del Rocio
Seville, Andalusia, Spain, 41013
Actively Recruiting
71
Hospital Universitari Vall d Hebron
Barcelona, Catalonia, Spain, 08035
Actively Recruiting
72
Hospital General Universitario Gregorio Maranon
Madrid, Spain, 28009
Actively Recruiting
73
National Cheng Kung University Hospital
Tainan, Taiwan, 70403
Actively Recruiting
74
National Taiwan University Hospital
Taipei, Taiwan, 10002
Actively Recruiting
75
Taipei Veterans General Hospital
Taipei, Taiwan, 11217
Actively Recruiting
76
Queen Elizabeth Hospital Birmingham
Birmingham, United Kingdom, B15 2TH
Actively Recruiting
77
Sarah Cannon Research Institute UK
London, United Kingdom, W1G 6AD
Actively Recruiting
Research Team
A
Amgen Call Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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