Actively Recruiting
Study Evaluating Dexmedetomidine in the Acute Treatment of Electrical Storm
Led by Ottawa Heart Institute Research Corporation · Updated on 2025-12-17
192
Participants Needed
1
Research Sites
168 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The objective of this study is to determine if there is a meaningful benefit to using the sedative medication dexmedetomidine in the acute treatment of patients with recurrent ventricular arrhythmias, known as electrical storm. This will be a multi-centre, double-blinded, placebo-controlled, randomized trial. Patients with electrical storm will be randomized to receive 48 to 72 hours of dexmedetomidine or placebo as part of their initial treatment in an intensive care unit.
CONDITIONS
Official Title
Study Evaluating Dexmedetomidine in the Acute Treatment of Electrical Storm
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients admitted to an intensive care unit with electrical storm
- Age 18 years or older
You will not qualify if you...
- Refractory shock lasting more than 30 minutes unrelated to ventricular arrhythmias requiring two or more vasopressors
- SCAI class D or E cardiogenic shock
- Cardiac arrest with no-flow and low-flow total time over 10 minutes before recruitment
- Ventricular arrhythmia caused by ST-segment elevation myocardial infarction with active ischemia
- Bradycardia with heart rate less than 40 beats per minute, bradycardia-induced ventricular tachyarrhythmia, or second degree Mobitz type 2 or greater atrioventricular block without a pacemaker
- Pregnancy
- Known allergy or intolerance to dexmedetomidine
- Unable to provide consent or have a substitute decision maker
- Use of dexmedetomidine or clonidine within 24 hours before randomization
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Ottawa Heart Institute
Ottawa, Ontario, Canada, K1Y 4W7
Actively Recruiting
Research Team
F
F. Daniel Ramirez, MD MSc
CONTACT
B
Benjamin Hibbert, MD PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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