Actively Recruiting
Study on Evaluating the Effectiveness of Statins in the Treatment of Moyamoya Disease
Led by Beijing Tiantan Hospital · Updated on 2025-02-10
330
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effectiveness of statins in treating moyamoya disease, a condition that affects blood flow in the brain. This observational study focuses on using multimodal magnetic resonance imaging to assess treatment outcomes. The main goal is to understand how statins impact cerebrovascular events such as transient ischemic attacks and strokes over an 18-month follow-up period. Participants will receive either revascularization or conservative management as part of the study treatment. The study monitors various health aspects including neurological function, cognitive abilities, structural changes in brain arteries, cerebral blood flow, incidence of new cerebral infarcts, hemodynamic changes, and blood lipid levels. These evaluations occur at 12 and 18 months after treatment begins. During the study, participants will undergo imaging follow-ups and neurological assessments. Researchers will collect data on cerebrovascular events and changes in brain structure and function. The study lasts at least 18 months, with ongoing monitoring to measure the rate of cerebrovascular events and other health outcomes related to moyamoya disease and its treatment.
CONDITIONS
Brief Title
Study on Evaluating the Effectiveness of Statins in the Treatment of Moyamoya Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Imaging examination meets diagnostic criteria for moyamoya disease
- Signed informed consent form
- Age 18 years or older
- Baseline modified Rankin Scale (mRS) score of 2 or less
- Receiving revascularization or conservative treatment
- At least one imaging follow-up result available
You will not qualify if you...
- Having atherosclerosis, autoimmune diseases, meningitis, Down syndrome, cranial trauma, or prior radioactive head irradiation that may cause secondary cerebrovascular disease or moyamoya syndrome
- Under 18 years old
- Refusal to participate in the study
- Pregnant patients
- Having intracranial aneurysms, cerebrovascular malformations, brain tumors, or hydrocephalus
- History of stroke more than three months before moyamoya disease diagnosis
- History of coronary heart disease or previous cardiovascular/cerebrovascular surgeries including cerebral revascularization, artery stenting, endarterectomy, or coronary bypass
- Allergy to contrast media
- Missing or unanalyzable imaging data
- Refusal or inability to undergo imaging follow-up
- Currently using other types of lipid-lowering drugs
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 18 months
Participants who undergo revascularization or conservative treatment are observed to evaluate effectiveness and changes in neurological and cognitive functions, cerebral blood perfusion, and vascular remodeling.
Assessments at 12 and 18 months after treatment
Trial Site Locations
Total: 1 location
1
Beijing Tiantan Hospital
Beijing, China, China, 100070
Actively Recruiting
Research Team
Q
Qian Zhang
C
Chaofan Zeng
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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