Actively Recruiting
Study Evaluating the Impact of Using Triplex Rapid Diagnostic Tests (SARS-CoV-2/Influenza/RSV) on Antibiotic Prescribing in the General Population in Community Settings
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2026-01-14
2000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Respiratory infections caused by viruses such as influenza, SARS-CoV-2, and respiratory syncytial virus (RSV) are common, especially during winter. These illnesses often have symptoms that make it hard to tell if the infection is viral or bacterial, leading to frequent antibiotic prescriptions even when not necessary. Excessive antibiotic use contributes to bacterial resistance, a serious public health concern. This study aims to evaluate whether using a rapid test called TROD, which quickly detects these viruses, can reduce unnecessary antibiotic prescriptions in community settings during the 2025-2026 autumn-winter season. The study involves two periods for each participating doctor: first, a control period where doctors treat patients without using the TROD test, and second, an intervention period where doctors use the TROD test on patients. Each period includes 10 patients who meet the eligibility criteria. The TROD test uses a nasal swab to identify SARS-CoV-2, influenza viruses, and RSV in under 15 minutes. Doctors may prescribe antibiotics based on usual practice during the control period, and with guidance from the TROD test results during the intervention period. Participants will be monitored for antibiotic prescriptions from the day of consultation to 14 days later. Researchers will collect data on antibiotic use, re-consultations, hospitalizations, and test accuracy compared to standard PCR tests. Patient characteristics and doctors’ practices will also be studied. The research aims to assess how the TROD test impacts antibiotic prescribing, viral infection detection, and healthcare costs, supporting efforts to reduce antibiotic resistance.
CONDITIONS
Brief Title
Study Evaluating the Impact of Using Triplex Rapid Diagnostic Tests (SARS-CoV-2/Influenza/RSV) on Antibiotic Prescribing
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 1 year or older
- Presenting with fever over 38°C within the past 72 hours and at least one of the following symptom combinations: rhinorrhea and/or nasal obstruction with cough; body aches, cough, and fatigue; sore throat with negative strepto-test; cough alone; or ear pain
- Or suspicion of lower respiratory tract infection with signs such as respiratory rate over 20/min, heart rate over 100/min, fatigue, body aches, chills, or fever along with cough, sputum, chest pain, or abnormal lung sounds
- Affiliation with the national health insurance system
- Informed consent from adult participant or guardian for minors
You will not qualify if you...
- Requirement for hospitalization
- Presence of a non-respiratory infection requiring antibiotic treatment
- Patients covered by State Medical Aid (AME)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Period covering inclusion and 14 days after
Participants are observed without the use of triplex rapid diagnostic tests (TROD), and doctors may prescribe antibiotics as usual based on clinical judgment.
1 initial visit plus follow-up assessments up to 14 days
Duration - Period covering inclusion and 14 days after
Participants undergo testing with triplex rapid diagnostic tests (TROD) for SARS-CoV-2, influenza, and RSV during consultation, which may influence antibiotic prescribing decisions.
1 initial visit with TROD testing plus follow-up assessments up to 14 days
Trial Site Locations
Total: 1 location
1
Assistance Publique - Hôpitaux de Paris
Garches, France
Actively Recruiting
Research Team
A
Aurélien DINH, MD, PhD
J
Jacques ROPERS, PharmD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
FACTORIAL
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
2
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