Actively Recruiting
A Study Evaluating the Performance of Using AI Software and Chest X-rays to Screen for Osteoporosis as Compared to Standard DXA Scans in Patients 50 Years and Older
Led by Promedius Inc · Updated on 2026-02-19
595
Participants Needed
3
Research Sites
2 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this study is to assess the performance of an artificial intelligence software (Osteo Signal) in detecting osteoporosis risk in adults 50 years and older. The main question it aims to answer is: What is the accuracy of the software in detecting osteoporosis risk on chest x-ray images as compared to the standard technique of dual-energy x-ray absorptiometry (DXA)? There is no direct involvement of participants in this study as it will use data from individuals who have already had a chest x-ray and a DXA scan taken in the past.
CONDITIONS
Official Title
A Study Evaluating the Performance of Using AI Software and Chest X-rays to Screen for Osteoporosis as Compared to Standard DXA Scans in Patients 50 Years and Older
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 50 years or older at the time of chest x-ray
- Availability of posteroanterior (PA) chest x-ray and DXA scan with a valid T-score measurement
- Both DXA scan and chest x-ray performed within 6 months (182 days) of each other
- X-ray and DXA scans performed on or after January 1, 2010
- Complete metadata (sex and age) available on PACS or hospital records
You will not qualify if you...
- Non-diagnostic quality or incomplete imaging of DXA or chest x-ray
- DXA scans missing T-score or technically inadequate
- Chest x-rays that are non-PA projection, have motion artifacts, inadequate thoracic visualization, or missing metadata
- Image format incompatibility such as non-DICOM or corrupted files
- Chest x-ray more than 6 months from the date of the DXA scan
- Previous diagnosis or treatment of osteoporosis within 12 months before the DXA scan
- Use of anti-osteoporotic medications for 3 months continuously before the chest x-ray
- Diagnosis of any metabolic bone disease prior to the DXA scan
- Diagnosis of metabolic bone disease other than osteoporosis or osteopenia up to 3 months after DXA scan
- Major chest wall or spinal deformities including severe scoliosis with Cobb angle over 40°, severe kyphosis, chest wall deformities affecting more than 30% of thoracic cage
- Previous thoracic or spinal surgery with metallic implants obscuring landmarks
- Extensive pulmonary consolidation, pleural effusion, lesions, or masses obscuring more than 30% of thoracic skeletal structures
- Subject has opted out of confidential data use for research purposes
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Erasmus University Medical Center Rotterdam,
Rotterdam, Netherlands, 3015 GD
Not Yet Recruiting
2
Mid and South Essex NHS Foundation Trust
Westcliff-on-Sea, Essex, United Kingdom, SS0 0RY
Not Yet Recruiting
3
Barts Health NHS Trust
London, United Kingdom, E1 4DG
Actively Recruiting
Research Team
K
Kim Bensalem
CONTACT
J
Jung Jinho
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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