Actively Recruiting
A Study on Exploring the Abscopal Effect Induced by Different Radioimmunotherapy Combination Patterns in the Treatment of Non-Small Cell Lung Cancer With Multiple Metastases
Led by Xinqiao Hospital of Chongqing · Updated on 2025-07-22
427
Participants Needed
1
Research Sites
130 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
It is planned to carry out a multicenter umbrella study to find the optimal organ combination and the best radioimmunotherapy combination pattern, so as to improve the survival of NSCLC patients with multiple metastases. At the same time, by using multimodal omics data, machine learning will be employed to construct a prediction model for the abscopal effect, and explore the immunoregulation of organ-specific radiotherapy and biomarkers of the abscopal effect. The main objective is to find the optimal organ combination and the best radioimmunotherapy combination pattern.
CONDITIONS
Official Title
A Study on Exploring the Abscopal Effect Induced by Different Radioimmunotherapy Combination Patterns in the Treatment of Non-Small Cell Lung Cancer With Multiple Metastases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with non-small cell lung cancer by pathological histology
- Have 3 to 6 metastatic lesions
- No brain metastasis or brain lesions are stable
- Negative for driver gene mutations including EGFR, ALK, ROS, BRAF, MET, RET
- ECOG performance status score of 0 to 1 with expected survival over 3 months
- Aged between 18 and 75 years
- Evaluated by PET-CT (including FDG and FMISO, optional)
- No contraindications for immunotherapy and radiotherapy
- Signed informed consent form
You will not qualify if you...
- Severe dysfunction of vital organs such as heart, liver, or kidney
- Presence of other malignant tumors
- Uncontrolled heart disease or myocardial infarction within the last 6 months
- History of mental illness
- Any other condition deemed unsuitable by the researchers for participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
the second affiliated hospital of Army medical university
Chongqing, Chongqing Municipality, China, 400037
Actively Recruiting
Research Team
J
Jianguo Sun, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
7
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