Actively Recruiting
Study of Factors Regulating Mast Cell Proliferation
Led by National Institute of Allergy and Infectious Diseases (NIAID) · Updated on 2026-05-07
600
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will examine growth factors that promote and inhibit mast cell proliferation resulting in mastocytosis, a disease of excessive mast cells in the body. These cells can release chemicals that cause itching, blisters, flushing, bone pain and abdominal pain. Patients up to 80 years of age with mastocytosis may be eligible for this 1-day study. Participants will have one visit at NIH lasting up to 8 hours, during which they will undergo the following tests and procedures: * Medical history and physical examination. * Laboratory studies, if medically indicated. * Blood tests to identify genetic changes important in the growth, development, and functioning of mast cells. * Bone marrow aspiration and biopsy. For the bone marrow procedure, the skin over the hipbone and the outer surface of the bone itself are numbed with local anesthesia. Then, a special needle is inserted into the hipbone and about 1 tablespoon of bone marrow is drawn into a syringe. Another needle is inserted into the same area to collect a small piece of the bone marrow. Additional procedures may include allergen testing, urinalysis, and 24-hour urine collection. Participants will receive an evaluation of their mastocytosis. ...
CONDITIONS
Official Title
Study of Factors Regulating Mast Cell Proliferation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants with mastocytosis aged 0 to 80 years may participate in telehealth visits
- Participants aged 2 to 80 years may participate on-site at NIH Clinical Center
- Histologic evidence of increased mast cell number by bone marrow and/or skin biopsy or documentation of mastocytosis in the skin with supporting photograph of diagnostic skin lesions
- Must be under the care of a primary care physician to be enrolled
- Ability to provide informed consent
- Biological relatives aged 2 to 80 years without diagnosis of mastocytosis by skin examination or biopsy
- Relatives must have a primary medical care provider outside NIH
- Ability to provide informed consent
You will not qualify if you...
- Anemia with hemoglobin less than 8 g/dL or hematocrit less than 24
- Any condition that the investigator believes contraindicates participation in the study
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
H
Hye Jeong C Bolan, R.N.
CONTACT
H
Hirsh D Komarow, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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