Actively Recruiting
Study of the Fine Structure and Temporal Envelope of the Human Cochlea in Response to Human Vocalizations
Led by CHU de Reims · Updated on 2024-07-12
20
Participants Needed
1
Research Sites
245 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
In humans, surface electrophysiological recordings of the cochlear nerve in response to a sound stimulus provide information about the cochlear's ability to encode sound. Depending on the stimulus, the fine structure and temporal envelope of the signal will vary, allowing us to determine its characteristics. By phenotyping patients before surgery using subjective and objective audiometric tests, it will be possible to isolate for each patient the moment when the fine structure disappears and when the temporal envelope is effective.
CONDITIONS
Official Title
Study of the Fine Structure and Temporal Envelope of the Human Cochlea in Response to Human Vocalizations
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female
- Aged between 18 and 80 years
- Normal otoscopic examination
- Scheduled for cerebellopontine angle surgery (microvascular decompression)
- Sensorineural hearing loss with average thresholds between 21 and 40 dB HL at 0.5, 1, 2, and 4 kHz (for hearing-impaired group)
- Normal hearing with thresholds less than or equal to 20 dB HL bilaterally at 0.5, 1, 2, and 4 kHz (for normal-hearing group)
- Affiliated to a social security scheme
- Provided written informed consent after reading study information
You will not qualify if you...
- Auditory nerve not accessible during surgery
- Complete tumor invasion of the cochlear nerve (stage III or IV neuroma, advanced meningioma)
- Anatomical features preventing nerve exposure for recordings not identified preoperatively (e.g., protrusion of posterior face of the rock)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Damien JOLLY
Reims, France
Actively Recruiting
Research Team
X
Xavier DUBERNARD
CONTACT
M
Marc LABROUSSE
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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