SUNRAY-01 trial protocol: an innovative study design of olomorasib and pembrolizumab with or without chemotherapy in KRAS G12C NSCLC.
Solange Peters, Maximilian Hochmair, Kathryn C Arbour...
https://pubmed.ncbi.nlm.nih.gov/41940628Actively Recruiting
Phase 3
Age: 18Years +
All Genders
ID06119581
SUNRAY-01 Global Study Comparing First-Line LY3537982 and Pembrolizumab Versus Placebo and Pembrolizumab in Advanced KRAS G12C-Mutant NSCLC with PD-L1 ≥50% or LY3537982 and Pembrolizumab, Pemetrexed, Platinum Versus Placebo with Pembrolizumab, Pemetrexed, Platinum
Led by Eli Lilly and Company · Updated on 2026-06-03
1264
Participants Needed
422
Research Sites
165 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the addition of LY3537982 (olomorasib) to standard anti-cancer treatments in people with advanced non-small cell lung cancer (NSCLC) that has a specific KRAS G12C gene mutation. The study aims to see if combining LY3537982 with pembrolizumab, with or without chemotherapy, is more effective than standard care. This phase 3 trial includes participants with untreated advanced NSCLC and can last up to three years, depending on individual progress. Participants may receive different combinations of treatments in 21-day cycles, including LY3537982 taken orally with pembrolizumab given intravenously, sometimes combined with chemotherapy drugs pemetrexed and platinum (cisplatin or carboplatin). Some groups receive placebo pills instead of LY3537982. The study has multiple parts including dose optimization, safety lead-in, and randomized treatment phases. Participants can continue treatment until specific discontinuation criteria are met. During the trial, participants will undergo regular assessments for side effects and disease progression through scans and clinical evaluations. Researchers will measure progression-free survival, overall survival, response rates, and physical function, as well as lung cancer symptoms using questionnaires. Safety monitoring and quality-of-life assessments will continue during treatment and follow-up periods. The study collects data for up to three years to evaluate the treatments' impact.
CONDITIONS
Brief Title
A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Histologically or cytologically confirmed non-small cell lung cancer (NSCLC) with Stage IIIB-IIIC or Stage IV disease not suitable for curative surgery or radiation
- Tumor must have KRAS G12C mutation
- Known PD-L1 expression: Part A ≥50%, Part B 0%-100%, Part C <50%
- Measurable disease per RECIST v1.1 criteria
- ECOG performance status of 0 or 1
- Estimated life expectancy of at least 12 weeks
- Able to swallow capsules
- Adequate laboratory values
- Women of childbearing potential must have a negative pregnancy test and not be breastfeeding
- Use contraception consistent with local regulations
You will not qualify if you...
- Presence of additional validated targetable oncogenic mutations such as EGFR, ALK, BRAF V600E, HER2, MET exon 14, ROS1, RET, or NTRK1/2/3
- Prior systemic therapy for advanced or metastatic NSCLC, except one cycle of standard care if urgently needed
- Known active central nervous system metastases or carcinomatous meningitis
- For participants receiving pemetrexed and platinum: predominantly squamous histology
- Inability to avoid NSAIDs around the time of pemetrexed administration in cases of mild to moderate renal insufficiency
- Unable or unwilling to take folic acid or vitamin B12 supplements if receiving pemetrexed
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
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Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - Up to approximately 1 year
Participants receive oral LY3537982 or placebo combined with intravenous pembrolizumab, with or without intravenous chemotherapy (pemetrexed and platinum), in 21-day cycles. Treatment continues until discontinuation criteria are met.
Repeated visits every 3 weeks during treatment cycles
Trial Site Locations
Total: 422 locations
1
Clearview Cancer Institute
Huntsville, Alabama, United States, 35805
Actively Recruiting
2
Banner MD Anderson Cancer Center
Gilbert, Arizona, United States, 85234
Actively Recruiting
3
Banner University Medical Center Phoenix
Phoenix, Arizona, United States, 85006
Actively Recruiting
4
The University of Arizona Cancer Center - North Campus
Tucson, Arizona, United States, 85719
Actively Recruiting
5
Highlands Oncology Group
Springdale, Arkansas, United States, 72762
Actively Recruiting
6
Cedars-Sinai Medical Center
Los Angeles, California, United States, 90048
Actively Recruiting
7
Mercy Cancer Center
Merced, California, United States, 95340
Actively Recruiting
8
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Torrance, California, United States, 90502
Completed
9
BASS Cancer Center
Walnut Creek, California, United States, 94598
Actively Recruiting
10
USO - Rocky Mountain Cancer Centers
Lone Tree, Colorado, United States, 80124
Actively Recruiting
11
Yale University School of Medicine
New Haven, Connecticut, United States, 06510
Actively Recruiting
12
Sibley Memorial Hospital
Washington D.C., District of Columbia, United States, 20016
Actively Recruiting
13
Millennium Oncology Research Clinic
Hollywood, Florida, United States, 33024
Actively Recruiting
14
University of Florida - Jacksonville
Jacksonville, Florida, United States, 32209
Actively Recruiting
15
Miami Cancer Institute at Baptist Health, Inc.
Miami, Florida, United States, 33176
Actively Recruiting
16
Ocala Oncology Center PL DBA Florida Cancer Affiliates - Ocala
Ocala, Florida, United States, 34474
Actively Recruiting
17
Orlando Health Cancer Institute
Orlando, Florida, United States, 32806
Not Yet Recruiting
18
Comprehensive Hematology Oncology
St. Petersburg, Florida, United States, 33709
Actively Recruiting
19
University Cancer & Blood Center, LLC
Athens, Georgia, United States, 30607
Actively Recruiting
20
Emory University School of Medicine- Grady Campus
Atlanta, Georgia, United States, 30303
Actively Recruiting
21
Winship Cancer Institute, Emory University
Atlanta, Georgia, United States, 30322
Actively Recruiting
22
University of Illinois at Chicago
Chicago, Illinois, United States, 60612
Actively Recruiting
23
University of Chicago Hospital
Chicago, Illinois, United States, 60637
Actively Recruiting
24
Springfield Clinic Main Campus
Springfield, Illinois, United States, 62702
Actively Recruiting
25
Parkview Research Center at Parkview Regional Medical Center
Fort Wayne, Indiana, United States, 46845
Actively Recruiting
26
Indiana University Melvin and Bren Simon Cancer Center
Indianapolis, Indiana, United States, 46202
Actively Recruiting
27
Franciscan Health
Indianapolis, Indiana, United States, 46237
Actively Recruiting
28
Community Cancer Center North
Indianapolis, Indiana, United States, 46250
Actively Recruiting
29
The University of Kansas Cancer Center - Westwood
Westwood, Kansas, United States, 66205
Actively Recruiting
30
CHI Saint Joseph Cancer Center - East
Lexington, Kentucky, United States, 40509
Actively Recruiting
31
University of Kentucky Chandler Medical Center
Lexington, Kentucky, United States, 40536
Actively Recruiting
32
Mary Bird Perkins Cancer Center
Baton Rouge, Louisiana, United States, 70809
Actively Recruiting
33
Johns Hopkins Bayview Medical Center
Baltimore, Maryland, United States, 21224
Actively Recruiting
34
USO - Maryland Oncology Hematology
Columbia, Maryland, United States, 21044
Actively Recruiting
35
Boston Medical Center
Boston, Massachusetts, United States, 02118
Actively Recruiting
36
Lahey Hospital & Medical Center
Burlington, Massachusetts, United States, 01805
Actively Recruiting
37
University of Michigan
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
38
Karmanos Cancer Institute
Detroit, Michigan, United States, 48201
Actively Recruiting
39
The Cancer & Hematology Centers
Grand Rapids, Michigan, United States, 49503
Actively Recruiting
40
Allina Health Cancer Institute - Abbott Northwestern Hospital
Minneapolis, Minnesota, United States, 55407
Actively Recruiting
41
HealthPartners Cancer Research Center
Saint Paul, Minnesota, United States, 55101
Actively Recruiting
42
North Mississippi Hematology and Oncology Associates
Tupelo, Mississippi, United States, 38801
Actively Recruiting
43
Oncology Hematology Associates
Springfield, Missouri, United States, 65807
Actively Recruiting
44
Comprehensive Cancer Centers of Nevada
Las Vegas, Nevada, United States, 89169
Actively Recruiting
45
Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, United States, 03756
Actively Recruiting
46
The Valley Hospital, Inc.
Paramus, New Jersey, United States, 07652
Actively Recruiting
47
University of New Mexico Comprehensive Cancer Center
Albuquerque, New Mexico, United States, 87131
Actively Recruiting
48
Maimonides Cancer Center
Brooklyn, New York, United States, 11220
Actively Recruiting
49
Northwell Health/ RJ Zuckerberg Cancer Center
Lake Success, New York, United States, 11042
Actively Recruiting
50
Perlmutter Cancer Center at NYU Langone Hospital - Long Island
Mineola, New York, United States, 11501
Actively Recruiting
51
Laura and Isaac Perlmutter Cancer Center
New York, New York, United States, 10016
Actively Recruiting
52
Manhattan Eye, Ear and Throat Hospital
New York, New York, United States, 10065
Actively Recruiting
53
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
54
University of North Carolina Medical Center
Chapel Hill, North Carolina, United States, 27599
Actively Recruiting
55
Duke Cancer Institute
Durham, North Carolina, United States, 27710
Actively Recruiting
56
UNC REX Cancer Center
Raleigh, North Carolina, United States, 27607
Actively Recruiting
57
Miami Valley Hospital South
Centerville, Ohio, United States, 45459
Not Yet Recruiting
58
USO - Oncology Hematology Care
Cincinnati, Ohio, United States, 45242
Actively Recruiting
59
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer -T
Columbus, Ohio, United States, 43210
Actively Recruiting
60
USO - Oncology Associates of Oregon
Eugene, Oregon, United States, 97401
Actively Recruiting
61
Asante Rogue Regional Medical Center
Medford, Oregon, United States, 97504
Actively Recruiting
62
Providence Portland Medical Center
Portland, Oregon, United States, 97213
Actively Recruiting
63
Providence St. Vincent Medical Center
Portland, Oregon, United States, 97225
Actively Recruiting
64
Kaiser Permanente Interstate Medical Office Central
Portland, Oregon, United States, 97227
Actively Recruiting
65
USO - Alliance Cancer Specialists, PC
Horsham, Pennsylvania, United States, 19044
Actively Recruiting
66
Thomas Jefferson University, Sidney Kimmel Cancer Center - Clinical Trials Office
Philadelphia, Pennsylvania, United States, 19107
Actively Recruiting
67
UPMC Hillman Cancer Center
Pittsburgh, Pennsylvania, United States, 15232
Actively Recruiting
68
Lifespan Cancer Institute
Providence, Rhode Island, United States, 02903
Actively Recruiting
69
Medical University of South Carolina
Charleston, South Carolina, United States, 29425
Actively Recruiting
70
Prisma Health Cancer Institute
Greenville, South Carolina, United States, 29605
Actively Recruiting
71
Lexington Medical Center
West Columbia, South Carolina, United States, 29169
Actively Recruiting
72
Tennessee Oncology Chattanooga
Chattanooga, Tennessee, United States, 37404
Actively Recruiting
73
University of Tennessee Medical Center
Knoxville, Tennessee, United States, 37920
Actively Recruiting
74
Baptist Memorial Hospital-Memphis
Memphis, Tennessee, United States, 38120
Actively Recruiting
75
Tennessee Oncology
Nashville, Tennessee, United States, 37203
Actively Recruiting
76
USO - US Oncology Research Network
Nashville, Tennessee, United States, 37203
Actively Recruiting
77
USO - Texas Oncology
Austin, Texas, United States, 78745
Actively Recruiting
78
William Beaumont Army Medical Center
Fort Bliss, Texas, United States, 79918
Actively Recruiting
79
Houston Methodist Hospital
Houston, Texas, United States, 77030
Actively Recruiting
80
University of Texas MD Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
81
USO - Texas Oncology
Webster, Texas, United States, 77598
Actively Recruiting
82
The University of Vermont Medical Center Inc.
Burlington, Vermont, United States, 05401
Actively Recruiting
83
University of Virginia Health System
Charlottesville, Virginia, United States, 22903
Actively Recruiting
84
USO - Virginia Cancer Specialists
Fairfax, Virginia, United States, 22031
Actively Recruiting
85
VCU Health Adult Outpatient Pavillion
Richmond, Virginia, United States, 23219
Actively Recruiting
86
Swedish Cancer Institute - Edmonds
Edmonds, Washington, United States, 98026
Actively Recruiting
87
Kadlec Clinic Hematology and Oncology
Kennewick, Washington, United States, 99336
Actively Recruiting
88
Swedish Medical Center
Seattle, Washington, United States, 98104
Actively Recruiting
89
VA Puget Sound Health Care System
Seattle, Washington, United States, 98108
Actively Recruiting
90
USO - Northwest Cancer Specialists
Vancouver, Washington, United States, 98684
Actively Recruiting
91
SSM Health Dean Medical Group - South Madison Campus Health Research/Circuit Clinical
Madison, Wisconsin, United States, 53715
Actively Recruiting
92
Royal Adelaide Hospital
Adelaide, Australia, 5000
Actively Recruiting
93
Icon Cancer Centre Wesley
Auchenflower, Australia, 4066
Actively Recruiting
94
Ballarat Health Services
Ballarat Central, Australia, 3350
Actively Recruiting
95
Sunshine Coast University Hospital
Birtinya, Australia, 4575
Actively Recruiting
96
Gosford Hospital
Gosford, Australia, 2250
Actively Recruiting
97
Mackay Base Hospital
Mackay, Australia, 4740
Actively Recruiting
98
St Vincent's Hospital
Melbourne, Australia, 3065
Actively Recruiting
99
Sir Charles Gairdner Hospital
Perth, Australia, 6009
Actively Recruiting
100
Goulburn Valley Health
Shepparton, Australia, 3630
Actively Recruiting
101
Gold Coast University Hospital
Southport, Australia, 4215
Actively Recruiting
102
The Townsville Hospital
Townsville, Australia, 4814
Actively Recruiting
103
Landeskrankenhaus Feldkirch
Feldkirch, Austria, 6800
Actively Recruiting
104
Ordensklinikum Linz GmbH Elisabethinen
Linz, Austria, 4020
Actively Recruiting
105
Klinik Floridsdorf
Vienna, Austria, 1210
Actively Recruiting
106
ZNA Middelheim
Antwerp, Belgium, 2020
Actively Recruiting
107
CHIREC - site delta
Auderghem, Belgium, 1160
Actively Recruiting
108
AZ Sint-Jan Brugge-Oostende AV
Bruges, Belgium, 8000
Actively Recruiting
109
UZ Gent
Ghent, Belgium, 9000
Actively Recruiting
110
AZ Groeninge Campus Kennedylaan
Kortrijk, Belgium, 8500
Actively Recruiting
111
UZ Leuven
Leuven, Belgium, 3000
Actively Recruiting
112
AZ Sint-Maarten
Mechelen, Belgium, 2800
Actively Recruiting
113
Clinique Saint Pierre
Ottignies, Belgium, 1340
Actively Recruiting
114
AZ Glorieux Ronse
Ronse, Belgium, 9600
Actively Recruiting
115
Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant-Godinne - Site Godinne
Yvoir, Belgium, 5530
Actively Recruiting
116
Fundação Pio XII - Hospital de Câncer de Barretos
Barretos, Brazil, 14784400
Actively Recruiting
117
Hospital Tacchini
Bento Gonçalves, Brazil, 95700-084
Actively Recruiting
118
Hospital São Domingos
Bequimão, Brazil, 65060-645
Actively Recruiting
119
Sirio-Libanes Brasilia - Centro de Oncologia - Asa Sul
Brasília, Brazil, 70200-730
Actively Recruiting
120
Hospital Universitário Evangélico Mackenzie
Curitiba, Brazil, 80730-150
Actively Recruiting
121
Centro de Pesquisa Clínica do Instituto do Câncer do Ceará
Fortaleza, Brazil, 60430235
Actively Recruiting
122
ONCOSITE - Centro de Pesquisa Clinica em Oncologia
Ijuí, Brazil, 98700-000
Actively Recruiting
123
Hospital Brasilia
Lago Sul, Brazil, 71.635-610
Actively Recruiting
124
Hospital de Cancer de Londrina
Londrina, Brazil, 86015-520
Actively Recruiting
125
Liga Norte Riograndense Contra o Câncer
Natal, Brazil, 59062-000
Actively Recruiting
126
Hospital São Lucas da PUCRS
Porto Alegre, Brazil, 90610-000
Actively Recruiting
127
Oncominas
Pouso Alegre, Brazil, 37554-216
Actively Recruiting
128
Instituto Nacional de Câncer José Alencar Gomes da Silva - INCA
Rio de Janeiro, Brazil, 20231-050
Actively Recruiting
129
Centro de Tratamento de Tumores Botafogo para Oncoclinicas Rio de Janeiro SA
Rio de Janeiro, Brazil, 22250-905
Actively Recruiting
130
Instituto D'Or Pesquisa e Ensino
Rio de Janeiro, Brazil, 22271-110
Actively Recruiting
131
Clinica Amo - Rio Vermelho
Salvador, Brazil, 41950-640
Actively Recruiting
132
Faculdade de Medicina do ABC
Santo André, Brazil, 09060-650
Actively Recruiting
133
Fundação Faculdade Regional de Medicina de São José do Rio Preto
São José do Rio Preto, Brazil, 15090000
Actively Recruiting
134
COE Ensino e Pesquisa
São José dos Campos, Brazil, 12242-660
Actively Recruiting
135
Icesp - Instituto Do Câncer Do Estado de São Paulo
São Paulo, Brazil, 01246-000
Actively Recruiting
136
Hospital Sírio Libanês
São Paulo, Brazil, 01308-060
Actively Recruiting
137
Hospital Santa Catarina - Paulista
São Paulo, Brazil, 01310-000
Actively Recruiting
138
Hospital BP
São Paulo, Brazil, 01321-001
Actively Recruiting
139
Hospital Paulistano
São Paulo, Brazil, 01321-001
Actively Recruiting
140
Centro Paulista de Oncologia Clínica
São Paulo, Brazil, 01452-000
Actively Recruiting
141
Núcleo de Pesquisa Clínica da Rede São Camilo
São Paulo, Brazil, 04014-002
Actively Recruiting
142
Instituto de Assistência Médica ao Servidor Público Estadual - IAMSPE/HSPE-FMO Conhecer Centro de Oncolog -T
São Paulo, Brazil, 04039-901
Actively Recruiting
143
Instituto D'Or de Pesquisa e Ensino (IDOR)
São Paulo, Brazil, 04543-000
Actively Recruiting
144
CEDOES
Vitória, Brazil, 29055450
Actively Recruiting
145
BC Cancer Abbotsford
Abbotsford British Columbia, Canada, V2S 0C2
Actively Recruiting
146
CIUSSS- saguenay-Lac-Saint-Jean
Chicoutimi, Canada, G7H 5H6
Actively Recruiting
147
BC Cancer Vancouver
Vancouver, Canada, V5Z 4E6
Actively Recruiting
148
Cancer Hospital Chinese Academy of Medical Science
Beijing, China, 100021
Actively Recruiting
149
Beijing Cancer hospital
Beijing, China, 100142
Actively Recruiting
150
Jilin Province Tumor Hospital
Changchun, China, 130000
Actively Recruiting
151
Hunan Cancer Hospital
Changsha, China, 410013
Actively Recruiting
152
Hunan Cancer Hospital
Changsha, China, 410013
Actively Recruiting
153
The First People's Hospital of Changzhou
Changzhou, China, 213003
Actively Recruiting
154
The Third People's Hospital of Chengdu (CDTPH)
Chengdu, China, 610031
Actively Recruiting
155
Sichuan Cancer hospital
Chengdu, China, 610041
Actively Recruiting
156
West China Hospital, Sichuan University
Chengdu, China, 610041
Actively Recruiting
157
Fujian Cancer Hospital
Fuzhou, China, 350014
Actively Recruiting
158
The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, China, 510170
Actively Recruiting
159
Hainan General Hospital
Haikou, China, 570311
Actively Recruiting
160
The First Affiliated Hospital, Zhejiang University
Hangzhou, China, 310003
Actively Recruiting
161
Sir Run Run Shaw Hospital
Hangzhou, China, 310016
Actively Recruiting
162
Zhejiang Cancer Hospital
Hangzhou, China, 310022
Actively Recruiting
163
Harbin Medical University Cancer Hospital
Harbin, China, 150081
Actively Recruiting
164
Jinan Central Hospital
Jinan, China, 250013
Actively Recruiting
165
Shandong Cancer Hospital
Jinan, China, 250117
Actively Recruiting
166
Taizhou Hospital of Zhejiang Province
Linhai, China, 317099
Actively Recruiting
167
LinYi Cancer Hospital
Linyi, China, 276001
Actively Recruiting
168
Liuzhou People's Hospital
Liuzhou, China, 545006
Actively Recruiting
169
The First Affiliated Hospital of Nanchang University
Nanchang, China, 330006
Actively Recruiting
170
Nanjing First Hospital
Nanjing, China, 210012
Actively Recruiting
171
Shanghai Chest Hospital
Shanghai, China, 200030
Actively Recruiting
172
Tianjin Medical University Cancer Institute & Hospital
Tianjin, China, 300060
Actively Recruiting
173
Xinjiang Medical University Cancer Hospital - Urumqi
Ürümqi, China, 830000
Actively Recruiting
174
Tongji Hospital Tongji Medical,Science & Technology
Wuhan, China, 430030
Actively Recruiting
175
Wuhan Union Hospital
Wuhan, China, 430048
Actively Recruiting
176
Renmin Hospital of Wuhan University
Wuhan, China, 430060
Actively Recruiting
177
Wannan Medical College Yijishan Hospital
Wuhu, China, 241001
Actively Recruiting
178
The First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, China, 710061
Actively Recruiting
179
Xiangyang Central Hospital
Xiangyang, China, 441021
Actively Recruiting
180
Yichang Central People's Hospital
Yichang, China, 443003
Actively Recruiting
181
Affiliated Hospital of Guangdong Medical University
Zhanjiang, China, 524001
Actively Recruiting
182
ZhuZhou Central Hospital
Zhuzhou, China, 412007
Actively Recruiting
183
Nemocnice AGEL Ostrava - Vitkovice a.s.
Ostrava, Czechia, 703 84
Actively Recruiting
184
Fakultni nemocnice Bulovka
Prague, Czechia, 180 81
Actively Recruiting
185
Roskilde University Hospital
Roskilde, Denmark, 4000
Actively Recruiting
186
Sainte Catherine Institut du Cancer Avignon Provence
Avignon, France, 84918
Actively Recruiting
187
Hospices Civils de Lyon - Hopital Louis Pradel
Bron, France, 69677
Actively Recruiting
188
CHU Lille - Institut Coeur Poumon
Lille, France, 59037
Actively Recruiting
189
Centre Leon Berard
Lyon Cedex08, France, 69373
Actively Recruiting
190
Centre Antoine-Lacassagne
Nice, France, 06189
Actively Recruiting
191
Institut Curie
Paris, France, 75248
Actively Recruiting
192
CHU Bordeaux Haut-Leveque
Pessac, France, 33600
Actively Recruiting
193
Centre Hospitalier Universitaire de Poitiers
Poitiers, France, 86021
Actively Recruiting
194
Institut Jean Godinot
Reims, France, 51726
Actively Recruiting
195
Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou
Rennes, France, 35033
Actively Recruiting
196
Institut de Cancérologie de l'Ouest
Saint-Herblain, France, 44805
Actively Recruiting
197
Nouvel Hôpital Civil (NHC)
Strasbourg, France, 67091
Actively Recruiting
198
Hôpital Foch
Suresnes, France, 92151
Actively Recruiting
199
Centre Hospitalier intercommunal de Toulon La Seyne sur Mer
Toulon, France, 83100
Actively Recruiting
200
CHU de Toulouse - Hopital Larrey
Toulouse, France, 31059
Actively Recruiting
201
Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois
Vandœuvre-lès-Nancy, France, 54511
Actively Recruiting
202
Hôpital Robert Schuman
Vantoux, France, 57070
Actively Recruiting
203
Gustave Roussy
Villejuif, France, 94800
Actively Recruiting
204
Evangelische Lungenklinik Berlin
Berlin, Germany, 13125
Actively Recruiting
205
Charité Campus Virchow-Klinikum
Berlin, Germany, 13353
Actively Recruiting
206
Helios Klinikum Emil von Behring Berlin-Zehlendorf
Berlin, Germany, 14165
Actively Recruiting
207
Klinikum Chemnitz
Chemnitz, Germany, 09116
Actively Recruiting
208
MV-Zentrum für Onkologie und Hämatologie
Cologne, Germany, 50677
Actively Recruiting
209
Onkologiezentrum Donauwörth
Donauwörth, Germany, 86609
Actively Recruiting
210
HELIOS Klinikum Erfurt
Erfurt, Germany, 99089
Actively Recruiting
211
Universitaetsklinikum Freiburg
Freiburg im Breisgau, Germany, 79106
Actively Recruiting
212
Asklepios Fachkliniken München-Gauting
Gauting, Germany, 82131
Actively Recruiting
213
Franziskus-Hospital Harderberg
Georgsmarienhütte, Germany, 49124
Actively Recruiting
214
LungenClinic Grosshansdorf
Großhansdorf, Germany, 22927
Actively Recruiting
215
Krankenhaus Martha-Maria Halle-Dölau
Halle, Germany, 06120
Actively Recruiting
216
Hämato-Onkologie Hamburg, Prof. Laack und Partner
Hamburg, Germany, 20251
Actively Recruiting
217
Asklepios Klinik Harburg
Hamburg, Germany, 21075
Actively Recruiting
218
Thoraxklinik-Heidelberg gGmbH
Heidelberg, Germany, 69126
Actively Recruiting
219
Universitätsklinikum Münster - Albert Schweitzer Campus
Münster, Germany, 48149
Actively Recruiting
220
Klinikum Nürnberg Nord
Nuremberg, Germany, 90419
Actively Recruiting
221
Universitaetsklinikum Tuebingen
Tübingen, Germany, 72076
Actively Recruiting
222
Agios Savvas Regional Cancer Hospital
Athens, Greece, 115 22
Actively Recruiting
223
Errikos Dunant Hospital Center
Athens, Greece, 115 26
Actively Recruiting
224
Sotiria Thoracic Diseases Hospital of Athens
Athens, Greece, 11527
Actively Recruiting
225
Attikon General University Hospital
Chaïdári, Greece, 12462
Actively Recruiting
226
University General Hospital of Heraklion
Heraklion, Greece, 715 00
Actively Recruiting
227
University Hospital of Patras
Pátrai, Greece, 26504
Actively Recruiting
228
"Theagenio" Cancer Hospital of Thessaloniki
Thessaloniki, Greece, 540 07
Actively Recruiting
229
European Interbalkan Medical Center
Thessaloniki, Greece, 570 01
Actively Recruiting
230
G. Papanikolaou General Hospital
Thessaloniki, Greece, 570 10
Actively Recruiting
231
Országos Korányi Pulmonológiai Intézet
Budapest, Hungary, 1121
Actively Recruiting
232
Országos Onkológiai Intézet
Budapest, Hungary, 1122
Actively Recruiting
233
Budapesti Uzsoki Utcai Kórház
Budapest, Hungary, 1145
Actively Recruiting
234
Farkasgyepui Tudogyogyintezet
Farkasgyepű, Hungary, 8582
Actively Recruiting
235
Bacs-Kiskun Megyei Korhaz
Kecskemét, Hungary, 6000
Actively Recruiting
236
Hemato Oncology Clinic
Ahmedabad, India, 380054
Actively Recruiting
237
KLES Dr. Prabhakar Kore Hospital & M.R.C
Belagavi, India, 590010
Actively Recruiting
238
SRV Hospitals
Bengaluru, India, 560027
Actively Recruiting
239
All India Institute of Medical Sciences
Bhubaneswar, India, 751019
Actively Recruiting
240
Ashwin Hospital
Coimbatore, India, 641012
Actively Recruiting
241
Nizam's Institute of Medical Sciences
Hyderabad, India, 500082
Actively Recruiting
242
Krishna Institute of Medical Sciences - Karad
Karad, India, 415539
Actively Recruiting
243
Kolhapur Cancer Centre Private Limited
Kolhāpur, India, 416234
Actively Recruiting
244
HCG Manavata Cancer Centre
Nashik, India, 422001
Actively Recruiting
245
Advanced Centre for Treatment Research and Education in Cancer
Navi Mumbai, India, 410210
Actively Recruiting
246
Jawaharlal Institute Of Postgraduate Medical Education And Research
Puducherry, India, 605006
Actively Recruiting
247
Grant Medical Foundation - Ruby Hall Clinic
Pune, India, 411001
Actively Recruiting
248
Sahyadri Super Speciality Hospital
Pune, India, 411004
Actively Recruiting
249
Lifepoint Multispeciality Hospital
Pune, India, 411057
Actively Recruiting
250
Regional Cancer Centre - Thiruvananthapuram
Thiruvananthapuram, India, 695011
Actively Recruiting
251
Pacific Medical College & Hospital
Udaipur, India, 313001
Actively Recruiting
252
Tata Memorial Centre - Homi Bhabha Cancer Hospital
Varanasi, India, 221002
Actively Recruiting
253
Mahatma Gandhi Cancer Hospital and Research Institute
Visakhapatnam, India, 530017
Actively Recruiting
254
Instituto Tumori Giovanni Paolo II
Bari, Italy, 70124
Actively Recruiting
255
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
Bologna, Italy, 40138
Actively Recruiting
256
Policlinico "G. Rodolico"
Catania, Italy, 95123
Actively Recruiting
257
Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, Italy, 20133
Actively Recruiting
258
Istituto Nazionale Tumori IRCCS Fondazione Pascale
Naples, Italy, 80131
Actively Recruiting
259
Istituto Oncologico Veneto IRCCS
Padova, Italy, 35128
Actively Recruiting
260
Fondazione Policlinico Universitario Agostino Gemelli
Roma, Italy, 00168
Actively Recruiting
261
Istituto Nazionale Tumori Regina Elena
Rome, Italy, 00144
Actively Recruiting
262
Ospedale di Circolo e Fondazione Macchi Varese
Varese, Italy, 21100
Actively Recruiting
263
Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento
Verona, Italy, 37126
Actively Recruiting
264
National Hospital Organization Asahikawa Medical Center
Asahikawa, Japan, 0708644
Actively Recruiting
265
Juntendo University Hospital
Bunkyō City, Japan, 113-8431
Actively Recruiting
266
Tokyo Metropolitan Komagome Hospital
Bunkyō City, Japan, 113-8677
Actively Recruiting
267
National Hospital Organization Kyushu Cancer Center
Fukuoka, Japan, 811-1395
Actively Recruiting
268
Kyushu University Hospital
Fukuoka, Japan, 812-8582
Actively Recruiting
269
Saitama Medical University International Medical Center
Hidaka, Japan, 350-1298
Actively Recruiting
270
Himeji Medical Center
Himeji, Japan, 670-8520
Actively Recruiting
271
Kansai Medical University Hospital
Hirakata, Japan, 573-1191
Actively Recruiting
272
Kanazawa University Hospital
Kanazawa, Japan, 920-8641
Actively Recruiting
273
Ibaraki Prefectural Central Hospital
Kasama, Japan, 309-1793
Actively Recruiting
274
National Cancer Center Hospital East
Kashiwa, Japan, 277-8577
Actively Recruiting
275
Kobe City Medical Center General Hospital
Kobe, Japan, 650-0047
Actively Recruiting
276
Japanese Foundation for Cancer Research
Kōtō City, Japan, 135-8550
Actively Recruiting
277
University Hospital,Kyoto Prefectural University of Medicine
Kyoto, Japan, 602-8566
Actively Recruiting
278
National Hospital Organization Shikoku Cancer Center
Matsuyama, Japan, 791-0280
Actively Recruiting
279
Shizuoka Cancer Center
Nagaizumi-cho,Sunto-gun, Japan, 411-8777
Actively Recruiting
280
Nagasaki University Hospital
Nagasaki, Japan, 852-8501
Actively Recruiting
281
Aichi Cancer Center Hospital
Nagoya, Japan, 464-8681
Actively Recruiting
282
Miyagi Cancer Center
Natori, Japan, 981-1293
Actively Recruiting
283
Niigata Cancer Center Hospital
Niigata, Japan, 951-8566
Actively Recruiting
284
Okayama University Hospital
Okayama, Japan, 700-8558
Actively Recruiting
285
Kindai University Hospital- Osakasayama Campus
Sakai, Japan, 590-0197
Actively Recruiting
286
National Hospital Organization Kinki-chuo Chest Medical Center
Sakai, Japan, 591-8555
Actively Recruiting
287
Hokkaido University Hospital
Sapporo, Japan, 060-8648
Actively Recruiting
288
National Hospital Organization Yamaguchi Ube Medical Center
Ube, Japan, 755-0241
Actively Recruiting
289
Tochigi Cancer Center
Utsunomiya, Japan, 320-0834
Actively Recruiting
290
Wakayama Medical University Hospital
Wakayama, Japan, 641-8510
Actively Recruiting
291
Kanagawa Cardiovascular and Respiratory Center
Yokohama, Japan, 236-0051
Actively Recruiting
292
Kanagawa cancer center
Yokohama, Japan, 2418515
Actively Recruiting
293
Tottori University Hospital
Yonago, Japan, 683-8504
Actively Recruiting
294
CIO - Centro de Inmuno-Oncología de Occidente
Guadalajara, Mexico, 44630
Actively Recruiting
295
PanAmerican Clinical Research - Guadalajara
Guadalajara, Mexico, 44670
Actively Recruiting
296
Actualidad Basada en la Investigación del Cáncer
Guadalajara, Mexico, 44680
Actively Recruiting
297
Renati Innovation
Guadalajara, Mexico, 44680
Actively Recruiting
298
Health Pharma Querétaro
Juriquilla, Mexico, 76230
Actively Recruiting
299
Preparaciones Oncológicas S.C.
León, Mexico, 37178
Actively Recruiting
300
Health Pharma Professional Research S.A. de C.V:
Mexico City, Mexico, 03100
Actively Recruiting
301
Higiea Oncologia
Mexico City, Mexico, 11819
Actively Recruiting
302
Hospital Universitario "Dr. Jose Eleuterio Gonzalez"
Monterrey, Mexico, 64460
Actively Recruiting
303
Avix Investigación Clinica, S.C.
Monterrey, Mexico, 64623
Actively Recruiting
304
Centro de Investigacion Clinica de Oaxaca
Oaxaca City, Mexico, 68020
Actively Recruiting
305
Clinica Integral Internacional de Oncología
Puebla City, Mexico, 72530
Actively Recruiting
306
Oncare - Unidad Valle
San Pedro Garza García, Mexico, 66220
Not Yet Recruiting
307
Arké SMO S.A de C.V
Veracruz, Mexico, 91900
Actively Recruiting
308
Jeroen Bosch Hospital
's-Hertogenbosch, Netherlands, 5223 GZ
Actively Recruiting
309
Medisch Spectrum Twente
Enschede, Netherlands, 7512 KZ
Actively Recruiting
310
Ziekenhuis St. Jansdal
Harderwijk, Netherlands, 3844 DG
Actively Recruiting
311
Tergooiziekenhuizen, locatie Hilversum
Hilversum, Netherlands, 1213 XZ
Actively Recruiting
312
Frisius Medisch Centrum
Leeuwarden, Netherlands, 8934 AD
Actively Recruiting
313
Leids Universitair Medisch Centrum
Leiden, Netherlands, 2333 ZA
Actively Recruiting
314
Erasmus Medisch Centrum
Rotterdam, Netherlands, 3015 GD
Actively Recruiting
315
ETZ Elisabeth
Tilburg, Netherlands, 5022 GC
Actively Recruiting
316
St. Antonius Ziekenhuis, locatie Utrecht
Utrecht, Netherlands, 3543 AZ
Actively Recruiting
317
Haukeland Universitetssjukehus
Bergen, Norway, 5021
Actively Recruiting
318
Drammen Sykehus, Vestre Viken HF
Drammen, Norway, 3004
Actively Recruiting
319
Sykehuset Innlandet HF Gjøvik
Gjøvik, Norway, 2819
Actively Recruiting
320
Akershus Universitetssykehus
Lørenskog, Norway, 1478
Actively Recruiting
321
Oslo universitetssykehus, Radiumhospitalet
Oslo, Norway, 0379
Actively Recruiting
322
Stavanger Universitetssykehus
Stavanger, Norway, 4021
Actively Recruiting
323
St. Olavs Hospital
Trondheim, Norway, 7030
Actively Recruiting
324
Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zaklad Opieki Zdrowotnej
Kielce, Poland, 25-734
Actively Recruiting
325
One Day Med
Szczecin, Poland, 70-419
Actively Recruiting
326
MICS Centrum Medyczne Torun
Torun, Poland, 87-100
Actively Recruiting
327
Centro Hospitalar E Universitário De Coimbra
Coimbra, Portugal, 3004-561
Actively Recruiting
328
Champalimaud Foundation
Lisbon, Portugal, 1400-038
Actively Recruiting
329
Hospital da Luz Lisboa
Lisbon, Portugal, 1500-650
Actively Recruiting
330
Hospital Pulido Valente
Lisbon, Portugal, 1769-001
Actively Recruiting
331
Centro Hospitalar do Porto - Hospital de Santo António
Porto, Portugal, 4099-001
Actively Recruiting
332
Hospital CUF Porto
Porto, Portugal, 4100-180
Actively Recruiting
333
Instituto Português de Oncologia do Porto Francisco Gentil, EPE
Porto, Portugal, 4200-072
Actively Recruiting
334
Lotus-Med
Bucharest, Romania, 012292
Actively Recruiting
335
SC Memorial Healthcare International SRL
Bucharest, Romania, 013812
Actively Recruiting
336
Gral Medical Diagnostic Center
Bucharest, Romania, 031422
Actively Recruiting
337
Institutul Oncologic
Cluj-Napoca, Romania, 400015
Actively Recruiting
338
Centrul de Oncologie "Sfântul Nectarie"
Craiova, Romania, 200542
Actively Recruiting
339
Ovidius Clinical Hospital OCH
Ovidiu, Romania, 905900
Actively Recruiting
340
S C Oncocenter Oncologie Clinica S R L
Timișoara, Romania, 300166
Actively Recruiting
341
Cabinet Medical Oncomed
Timișoara, Romania, 300239
Actively Recruiting
342
Chungbuk National University Hospital
Cheongju-si, South Korea, 28644
Actively Recruiting
343
Keimyung University Dongsan Hospital
Daegu, South Korea, 42601
Actively Recruiting
344
Kyungpook National University Chilgok Hospital
Deagu, South Korea, 41404
Actively Recruiting
345
Gangnam Severance Hospital, Yonsei University Health System
Gangnam-gu, South Korea, 06273
Actively Recruiting
346
National Cancer Center
Goyang-si, South Korea, 10408
Actively Recruiting
347
Chonnam National University Hwasun Hospital
Hwasun, South Korea, 58128
Actively Recruiting
348
Korea University Anam Hospital
Seoul, South Korea, 02841
Actively Recruiting
349
Severance Hospital, Yonsei University Health System
Seoul, South Korea, 03722
Actively Recruiting
350
Hanyang University Seoul Hospital
Seoul, South Korea, 04763
Actively Recruiting
351
Asan Medical Center
Seoul, South Korea, 05505
Actively Recruiting
352
Samsung Medical Center
Seoul, South Korea, 06351
Actively Recruiting
353
The Catholic University of Korea, Yeouido St. Mary's Hospital
Seoul, South Korea, 07345
Actively Recruiting
354
Korea University Guro Hospital
Seoul, South Korea, 08308
Actively Recruiting
355
The Catholic University Of Korea St. Vincent's Hospital
Suwon, South Korea, 16247
Actively Recruiting
356
Pusan National University Yangsan Hospital
Yangsan, South Korea, 50612
Actively Recruiting
357
CHUAC-Hospital Teresa Herrera
A Coruña, Spain, 15006
Actively Recruiting
358
Hospital Infanta Cristina
Badajoz, Spain, 06006
Actively Recruiting
359
OSI Ezkerraldea-Enkarterri-Cruces - Hospital Universitario Cruces
Barakaldo, Spain, 48903
Actively Recruiting
360
Parc de Salut Mar - Hospital del Mar
Barcelona, Spain, 08003
Actively Recruiting
361
Hospital Universitari Dexeus
Barcelona, Spain, 08028
Actively Recruiting
362
Hospital Universitari Vall d'Hebron
Barcelona, Spain, 08035
Actively Recruiting
363
Instituto Catalan de Oncologia - Hospital Duran i Reynals
Hospitalet, Spain, 08907
Actively Recruiting
364
Hospital Jerez de la Frontera
Jerez de la Frontera, Spain, 11407
Actively Recruiting
365
Hospital Insular de Gran Canaria
Las Palmas de Gran Canaria, Spain, 35016
Actively Recruiting
366
Complejo Asistencial Universitario de León - Hospital de León
León, Spain, 24071
Actively Recruiting
367
Hospital Universitario Ramón y Cajal
Madrid, Spain, 28034
Actively Recruiting
368
Hospital Universitario 12 de Octubre
Madrid, Spain, 28041
Actively Recruiting
369
H.R.U Málaga - Hospital General
Málaga, Spain, 29011
Actively Recruiting
370
Hospital Universitari Son Espases
Palma, Spain, 07120
Actively Recruiting
371
Complejo Hospitalario de Navarra
Pamplona, Spain, 31009
Actively Recruiting
372
Hospital Universitario Quironsalud Madrid
Pozuelo de Alarcón, Spain, 28223
Actively Recruiting
373
CHUS - Hospital Clinico Universitario
Santiago de Compostela, Spain, 15706
Actively Recruiting
374
Hospital Universitario Virgen Del Rocio
Seville, Spain, 41013
Actively Recruiting
375
Hospital Clinico de Valencia
Valencia, Spain, 46010
Actively Recruiting
376
Hospital Clínico Universitario Lozano Blesa
Zaragoza, Spain, 50009
Actively Recruiting
377
Mälarsjukhuset
Eskilstuna, Sweden, 631 88
Actively Recruiting
378
Västmanlands Sjukhus Västerås
Västerås, Sweden, 721 89
Actively Recruiting
379
CHUV (centre hospitalier universitaire vaudois)
Lausanne, Switzerland, 1011
Actively Recruiting
380
Kantonsspital Winterthur
Winterthur, Switzerland, 8401
Actively Recruiting
381
Changhua Christian Hospital
Changhua County, Taiwan, 50006
Actively Recruiting
382
Buddhist Dalin Tzu Chi General Hospital
Chiayi City, Taiwan, 622
Actively Recruiting
383
National Taiwan University Hospital Yun-Lin Branch Dou-Liou Region
Douliu, Taiwan, 640
Actively Recruiting
384
Hualien Tzu Chi Medical Center
Hualien City, Taiwan, 970
Actively Recruiting
385
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, Taiwan, 807
Actively Recruiting
386
Chang Gung Memorial Hospital at Kaohsiung
Kaohsiung Niao Sung Dist, Taiwan, 83301
Actively Recruiting
387
New Taipei Municipal TuCheng Hospital
New Taipei City, Taiwan, 236
Actively Recruiting
388
Chung Shan Medical University Hospital
Taichung, Taiwan, 402
Actively Recruiting
389
Taichung Veterans General Hospital
Taichung, Taiwan, 407
Actively Recruiting
390
National Cheng Kung University Hospital
Tainan, Taiwan, 704
Actively Recruiting
391
Chi Mei Medical Center
Tainan, Taiwan, 71004
Actively Recruiting
392
Chi Mei Hospital - Liouying Branch
Tainan, Taiwan, 73657
Actively Recruiting
393
National Taiwan University Hospital
Taipei, Taiwan, 10002
Actively Recruiting
394
National Taiwan University Cancer Center (NTUCC)
Taipei, Taiwan, 106
Actively Recruiting
395
Taipei Veterans General Hospital
Taipei, Taiwan, 11217
Actively Recruiting
396
Chang Gung Medical Foundation-Linkou Branch
Taoyuan, Taiwan, 333
Actively Recruiting
397
National Taiwan University Hospital - Hsinchu branch
Zhubei, Taiwan, 302
Actively Recruiting
398
Adana Medical Park Seyhan Hastanesi
Adana, Turkey (Türkiye), 01140
Actively Recruiting
399
Adana City Hospital
Adana, Turkey (Türkiye), 01370
Actively Recruiting
400
Ankara Etlik City Hospital
Ankara, Turkey (Türkiye), 06170
Actively Recruiting
401
Abdurrahman Yurtaslan Ankara Oncology, education and Research Hospital
Ankara, Turkey (Türkiye), 06200
Actively Recruiting
402
Ankara Bilkent Şehir Hastanesi
Ankara, Turkey (Türkiye), 06800
Actively Recruiting
403
Akdeniz Universitesi Hastanesi
Antalya, Turkey (Türkiye), 07059
Actively Recruiting
404
Memorial Antalya Hospital
Antalya, Turkey (Türkiye), 07090
Actively Recruiting
405
Antalya Egitim ve Arastırma Hastanesi
Antalya, Turkey (Türkiye), 07100
Not Yet Recruiting
406
Uludag Universitesi
Bursa, Turkey (Türkiye), 16059
Actively Recruiting
407
Dicle Üniversitesi
Diyarbakır, Turkey (Türkiye), 21200
Actively Recruiting
408
Bezmialem Vakf Üniversitesi
Istanbul, Turkey (Türkiye), 34093
Actively Recruiting
409
İ.A.Ü VM Medical Park Florya Hastanesi
Istanbul, Turkey (Türkiye), 34295
Actively Recruiting
410
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi
Istanbul, Turkey (Türkiye), 34722
Actively Recruiting
411
Ege Universitesi Hastanesi
Izmir, Turkey (Türkiye), 35100
Actively Recruiting
412
zmir Katip Çelebi Üniversitesi Atatürk Eitim Ve Aratrma Hastanesi
Izmir, Turkey (Türkiye), 35360
Actively Recruiting
413
Kocaeli Üniversitesi
Kocaeli, Turkey (Türkiye), 41380
Actively Recruiting
414
Ondokuz Mayıs Universitesi
Samsun, Turkey (Türkiye), 55270
Actively Recruiting
415
Aberdeen Royal Infirmary
Aberdeen, United Kingdom, AB25 2ZN
Actively Recruiting
416
Ninewells Hospital and Medical School
Dundee, United Kingdom, DD1 9SY
Actively Recruiting
417
Huddersfield Royal Infirmary
Huddersfield, United Kingdom, HD3 3EA
Actively Recruiting
418
St James's University Hospital
Leeds, United Kingdom, LS9 7TF
Actively Recruiting
419
The Christie NHS Foundation Trust
Manchester, United Kingdom, M20 4BX
Actively Recruiting
420
Mount Vernon Hospital
Northwood, United Kingdom, HA6 2RN
Actively Recruiting
421
Weston Park Hospital
Sheffield, United Kingdom, S10 2SJ
Actively Recruiting
422
New Cross Hospital
Wolverhampton, United Kingdom, WV10 0QP
Actively Recruiting
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Research Team
T
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
P
Physicians interested in becoming principal investigators please contact
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
8
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