Actively Recruiting
Study of Gastric Motility in Eosinophilic Gastritis
Led by Children's Hospital Medical Center, Cincinnati · Updated on 2026-03-31
30
Participants Needed
3
Research Sites
200 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Purpose: The study is a cross-sectional observational study designed to determine if eosinophilic gastritis (EG) results in gastric motility impairment. Hypothesis: Gastric dysfunction occurs in the natural history of EG but is underdiagnosed due, in part, to contraindications to the use of the standard meals used in gastric emptying studies.
CONDITIONS
Official Title
Study of Gastric Motility in Eosinophilic Gastritis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Eosinophilic gastritis confirmed by at least one endoscopy showing 30 or more eosinophils in 5 or more high powered fields with symptoms of EG
- Symptoms consistent with EG such as nausea, vomiting, early satiety, abdominal pain or bloating, regurgitation, or diarrhea starting at least one year before screening
- Symptoms suggesting possible gastric motility disorder in the 60 days before screening including nausea, vomiting, early satiety, or post-meal fullness or bloating
- Ability and willingness to tolerate and consume the oatmeal meal used in this study
You will not qualify if you...
- Diagnosis of eosinophilic enteritis
- Inflammatory bowel diseases like Crohn's disease or ulcerative colitis
- Known eosinophilic gastrointestinal disease-related conditions such as D 816 V Kit+ systemic mastocytosis, Marfan syndrome, or Loey's Dietz Syndrome
- Inflammatory or autoimmune disorders linked to gastric motility problems like systemic sclerosis, lupus, or eosinophilic fasciitis
- Uncontrolled diabetes or diabetic complications including gastroparesis, neuropathy, or nephropathy
- Use of opioid medications within 2 weeks before screening and during the study
- History of small bowel or stomach strictures or gastric surgeries/procedures such as pyloromyotomy, pyloric dilation or resection, vagotomy, bariatric surgery, post-Nissen fundoplication, or antrectomy with Billroth I, Billroth II, or Roux-en-Y gastrojejunostomy
- Past or current serious medical conditions such as advanced liver disease (Child's B or C), acute or chronic kidney disease with creatinine over 3 mg/dL, neurologic diseases like dysautonomia, achalasia, or adrenal insufficiency
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 3 locations
1
Northwestern University
Chicago, Illinois, United States, 60208
Actively Recruiting
2
The National Institutes of Health
Bethesda, Maryland, United States, 20892
Actively Recruiting
3
University of Utah
Salt Lake City, Utah, United States, 84112
Actively Recruiting
Research Team
R
Regina Yearout
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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