Actively Recruiting
Study of Glucose Tolerance Abnormalities Using Continuous Glucose Monitoring for the Identification of Early Loss of Pancreatic Islet Graft Function.
Led by University Hospital, Strasbourg, France · Updated on 2026-03-17
36
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Islet transplantation is associated with drastically improvement glucose control in people with type 1 diabetes. This treatment resulted in the disappearance of severe hypoglycemic events. However, its long-term effectiveness is limited by progressive loss of graft function. Currently, there is no standardized method to detect early dysfunction of the transplanted islets. This study aims to determine whether a parameter derived from continuous glucose monitoring (CGM), Time in Tight Range (70-140 mg/dL), is associated with pancreatic islet grafts function. The study hypothesis is that a decrease in Time in Tight Range reflects early loss of islet graft function.
CONDITIONS
Official Title
Study of Glucose Tolerance Abnormalities Using Continuous Glucose Monitoring for the Identification of Early Loss of Pancreatic Islet Graft Function.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years old or older
- Have insulin-dependent diabetes (type 1 diabetes or diabetes secondary to chronic pancreatitis, MODY, cystic fibrosis)
- Completed a full cycle of pancreatic islet transplantation: Islet Transplantation Alone, Islet After Kidney, or Simultaneous Islet Kidney
- Received more than 10,000 IEQ/kg of body weight, or less than 10,000 IEQ/kg but achieved insulin independence
- Provided consent for reuse of their data for this research
You will not qualify if you...
- Refusal to wear a continuous glucose monitoring device
- Pancreatic islet autotransplantation
- Unable to provide informed consent (difficulty understanding study information)
- Under judicial protection (safeguard of justice)
- Under guardianship or curatorship
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Hopitaux Universitaires de Strasbourg
Strasbourg, France, 67200
Actively Recruiting
Research Team
P
Pargol ZANDYAZDI
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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