Actively Recruiting
A Study of Herbal Supplements in Cancer Survivors With Constipation
Led by Memorial Sloan Kettering Cancer Center · Updated on 2025-12-04
70
Participants Needed
7
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to find out whether MZRW is an effective treatment for constipation in cancer survivors. The researchers will compare MZRW with placebo, a pill that looks like MZRW and is given in the same way, but contains no medication. The researchers will also study the effect MZRW has on the gut microbiome. The gut microbiome is a diverse community of microorganisms living in the digestive system, essential for digestion and immune function.
CONDITIONS
Official Title
A Study of Herbal Supplements in Cancer Survivors With Constipation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or greater
- Diagnosis of cancer, any type or stage
- Completed surgery, chemotherapy, immunotherapy, radiotherapy, or investigational therapy at least 1 month before study start
- Stable doses of hormone therapy or targeted therapies allowed
- Karnofsky functional score of 60 or higher
- Meet Rome IV criteria for functional constipation with two or more symptoms including straining, hard stools, incomplete evacuation, anorectal blockage, manual maneuvers, fewer than three spontaneous bowel movements per week, rare loose stools without laxatives, and insufficient criteria for irritable bowel syndrome
- Able to understand and complete all study assessments independently
- Able to provide signed informed consent in English
You will not qualify if you...
- Allergic history to herbs or Chinese medicine
- Significant abnormal liver function (ALT or AST more than 2 times upper limit) or kidney dysfunction (eGFR below 59 mL/min/1.73m²) within 1 month
- Signs or high risk of bowel obstruction including tumor invasion, recent abdominal surgery, or prior abdominal radiation
- Prescribed opioid antagonists for opioid-induced constipation and cannot stop them
- Women who are pregnant, breastfeeding, or not using proper contraception
- Must follow contraception guidelines for at least 30 days after last study drug dose
AI-Screening
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Trial Site Locations
Total: 7 locations
1
Memorial Sloan Kettering Basking Ridge (All Protocol Activities)
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
2
Memorial Sloan Kettering Monmouth (All Protocol Activities)
Middletown, New Jersey, United States, 07748
Actively Recruiting
3
Memorial Sloan Kettering Bergen (All Protocol Activities)
Montvale, New Jersey, United States, 07645
Actively Recruiting
4
Memorial Sloan Kettering Suffolk- Commack (All Protocol Activities)
Commack, New York, United States, 11725
Actively Recruiting
5
Memorial Sloan Kettering Westchester (All Protocol Activities)
Harrison, New York, United States, 10604
Actively Recruiting
6
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
New York, New York, United States, 10065
Actively Recruiting
7
Memorial Sloan Kettering Nassau (All Protocol Activities)
Rockville Centre, New York, United States, 11553
Actively Recruiting
Research Team
J
Jun Mao, MD, MSCE
CONTACT
Y
Yen Nien (Jason) Hou, PharmD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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