Actively Recruiting
A Study of High Dose Radiation Therapy for Locally Advanced Pancreatic Cancer That Responded to Initial Chemotherapy Treatment
Led by University Health Network, Toronto · Updated on 2026-04-16
43
Participants Needed
2
Research Sites
263 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to test the effect of high-dose radiation therapy after initial chemotherapy in patients with locally advanced pancreatic cancer. The main question it aims to answer is: • For patients with locally advanced pancreatic cancer that responded to initial chemotherapy (stayed stable or decreased in size), will high-dose RT (radiation therapy) contribute to improving treatment outcomes, enhancing quality of life, or increasing overall survival rates? Participants will: * Undergo an optional tumor biopsy. * Be treated with high dose radiation therapy. * Complete quality of life questionnaires. * Donate research blood samples.
CONDITIONS
Official Title
A Study of High Dose Radiation Therapy for Locally Advanced Pancreatic Cancer That Responded to Initial Chemotherapy Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have a confirmed diagnosis of locally advanced pancreatic cancer
- Have a pancreatic tumor smaller than 8.0 cm at treatment planning
- Have an ECOG performance status of 0 or 1 (Karnofsky 70% or higher)
- Have a life expectancy greater than 6 months
- Completed at least 16 weeks of first-line chemotherapy without cancer progression
- Have had at least 2 weeks since last chemotherapy before starting this study treatment
- Able to understand and sign informed consent
- Women must not be pregnant or breastfeeding and must have a pregnancy test within 4 weeks before registration
You will not qualify if you...
- Have metastatic disease at the time of registration
- Are younger than 18 years old
- Have had prior systemic treatment for metastatic disease
- Have had prior radiotherapy to the upper abdomen overlapping with study treatment area
- Are currently receiving any anti-cancer treatment including chemotherapy
- Have uncontrolled illnesses such as active infections, heart failure, unstable angina, arrhythmia, or psychiatric/social conditions limiting study compliance
- Are pregnant or breastfeeding
- Have other malignancies unless disease-free for at least 2 years or certain skin/cervical cancers treated within past 5 years
- Have diseases preventing high dose radiation therapy like scleroderma or ulcers in the treatment area
- Have contraindications for MRI such as pacemaker, metallic foreign bodies, severe claustrophobia, allergies to gadolinium, or severe kidney disease
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Princess Margaret Cancer Centre
Toronto, Ontario, Canada, M5G 2M9
Actively Recruiting
2
McGill University Health Centre
Montreal, Quebec, Canada, H4A 3J1
Actively Recruiting
Research Team
A
Anna Dodd
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
0
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