Actively Recruiting
Study of High-Precision Evaluation of Molecular ResiduaL Disease Through a PlatfOrm for Cancer TracKing and Interception (SHERLOCK)
Led by University Health Network, Toronto · Updated on 2026-05-11
7000
Participants Needed
1
Research Sites
260 weeks
Total Duration
On this page
Sponsors
U
University Health Network, Toronto
Lead Sponsor
P
Princess Margaret Hospital, Canada
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study will collect, annotate, and sequence biospecimens (blood, tissue, urine, saliva and surgery drainage) from patients across different cancer types to detect molecular residual disease (MRD). Imaging scans and clinical data will also be gathered. This will allow for early cancer interception, and hopefully prolong relapse-free survival across tumor types. Results of ctDNA testing will be provided for clinical decisions and to determine eligibility for other linked interventional interception therapeutic studies, each of which will have a separate protocol.
CONDITIONS
Official Title
Study of High-Precision Evaluation of Molecular ResiduaL Disease Through a PlatfOrm for Cancer TracKing and Interception (SHERLOCK)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with cancer confirmed by tissue biopsy, cytology, or for some cancers by imaging or biomarker tests
- Cancer planned for or treated with curative intent including surgery, radiation, or chemotherapy
- Curative treatment must be completed within 12 months before joining the study
- Patients on maintenance endocrine or biological therapy within 12 months of curative treatment completion are eligible
- Age 18 years or older
- Signed and dated informed consent form
You will not qualify if you...
- History of another active invasive cancer within 2 years before joining, except certain skin cancers and cervix carcinoma in situ
- Prior allogeneic stem cell transplant
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Princess Margaret Hospital
Toronto, Ontario, Canada, M5G 2M9
Actively Recruiting
Research Team
K
Kimberly Vuong
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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