A Systems Immunology Approach to Characterize the Immune Response in Sepsis and Its Long-term Complications

What this Trial Is About

Sepsis is a serious condition caused by an infection that disrupts the immune system, potentially leading to organ damage or failure. This research aims to understand the different immune response types, called immunotypes, that occur during and after sepsis. By studying these immunotypes and their effects on short- and long-term health, researchers hope to improve patient care and treatment selection in the future. This is a multicenter, prospective observational study involving 400 adult patients admitted to intensive or medium care units with sepsis. Blood samples will be collected at multiple times: within 48 hours of ICU admission, three days later, at hospital discharge, and at three and twelve months after discharge. The study involves no treatments beyond blood collection, which will be coordinated with routine care to reduce extra procedures. Follow-up assessments will include questionnaires or phone interviews. Participants will be monitored from ICU admission through one year after returning home. Researchers will analyze blood samples and clinical data to classify patients into immunotypes and observe how these relate to health outcomes. The primary outcomes focus on immune response classification at early ICU admission, day 3, and discharge. Secondary outcomes assess persistent immunotypes at three and twelve months post-discharge. The study is designed to minimize risks and burden, with no direct benefit to participants but potential future benefits for sepsis diagnosis and treatment.

A Study on How the Immune System Responds to Sepsis and Its Long-term Effects