What is Huperzine A Injection studying for postoperative delirium in elderly patients?

Huperzine A Injection is being studied to see if it can reduce delirium after non-cardiac surgery in patients aged 75 and older. This study aims to understand its effects on postoperative recovery and cognitive function after surgery. Participants will be randomly given either the injection or a placebo to measure these outcomes.

Who may be eligible for this postoperative delirium clinical trial?

Adults aged 75 years or older undergoing non-cardiac surgery under general anesthesia with an ASA grade III or IV may be eligible. Both men and women can participate. Important factors include surgery lasting at least 2 hours and no recent participation in other clinical trials. Please review eligibility criteria for more details.

Is there any cost to participate in this postoperative delirium clinical trial?

Study-related care, including the study drug and all trial visits, is provided at no cost. Personal travel expenses vary by participant and are not guaranteed to be covered. Participants should plan accordingly for any travel or accommodation costs.

Actively Recruiting

Phase Not Applicable

Age: 75Years +

All Genders

ID05242419

A Multi-center, Randomized, Double-blinded, Placebo-controlled Study of Huperzine A Injection in Reducing Postoperative Delirium in Elderly Patients Undergoing Non-cardiac Surgery

Led by Second Affiliated Hospital of Wenzhou Medical University · Updated on 2025-04-02

Participants Needed

Research Sites

4 weeks

Total Duration

AI-Summary

What this Trial Is About

Researchers are studying the effects of Huperzine A Injection on reducing postoperative delirium in elderly patients aged 75 and older who are undergoing non-cardiac surgery. This randomized, double-blinded, placebo-controlled trial aims to observe how this treatment may influence the occurrence of delirium after surgery in this older population. Participants will be randomly assigned to receive either Huperzine A Injection or a placebo of 0.9 Sodium Chloride Injection during their non-cardiac surgical procedure. The study includes patients with an anesthesia grade of III to IV and an estimated operation time of at least 2 hours. The treatments will be administered under controlled conditions to carefully assess their effects on postoperative delirium. During the study, participants will be monitored for delirium incidence within 7 days after surgery, with additional evaluations at 24, 48, and 72 hours post-operation. Researchers will also assess the type, severity, and duration of delirium, length of hospital stay, economic costs, complications, mortality rates, and cognitive function using the Mini-mental State Examination and EuroQol scale. Follow-up assessments will continue up to 2 months after surgery, with some evaluations occurring around 30 days after discharge.

CONDITIONS

Brief Title

A Study of Huperzine A Injection in Reducing Postoperative Delirium in Elderly Patients Undergoing Non-cardiac Surgery

Who Can Participate

Age: 75Years +

All Genders

Eligibility Criteria

You may qualify if you...

75 years old or older
Scheduled for non-cardiac surgery under general anesthesia
Anesthesia risk classified as American Society of Anesthesiologist (ASA) grade III to IV
Estimated surgery time of 2 hours or longer
Willing to voluntarily sign the informed consent form

You will not qualify if you...

Impaired kidney function with creatinine 1.5 times above normal laboratory limits
Abnormal liver function with ALT or AST levels 2 times above normal laboratory limits
Positive for infectious diseases
Central nervous system injury
History of delirium, epilepsy, long-term use of psychoactive drugs, or preoperative delirium
Diseases with drug contraindications including bronchial asthma, mechanical intestinal obstruction, urinary tract obstruction, or serious systemic diseases such as myocardial infarction, heart failure, angina, or sinus bradycardia
Known allergy to narcotic drugs or Huperzine A Injection
Use of incompatible drugs with Huperzine A Injection
Participation in other clinical trials within 3 months before this study
Unable to tolerate tests or cooperate with examinations
Presence of aphasia, audio-visual dysfunction, or other communication disorders
Judged by investigators as unsuitable for participation

Research Team

Ting Li, MD. PhD

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