Actively Recruiting
A Study to Identify an Optimal Dose of QCZ484 in Mild to Moderate Hypertensive Patients
Led by Novartis Pharmaceuticals · Updated on 2026-04-29
380
Participants Needed
84
Research Sites
158 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate the efficacy, safety and tolerability of QCZ484 or placebo, given subcutaneously, every 6 months, at different dose levels in patients with mild to moderate hypertension
CONDITIONS
Official Title
A Study to Identify an Optimal Dose of QCZ484 in Mild to Moderate Hypertensive Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed informed consent
- Males or females aged 18 to 75 years
- Diagnosis of hypertension
- Treatment naive or on maximum 2 anti-hypertensive medications and able to undergo 4-week washout
- Mean sitting systolic blood pressure ≥140 mmHg by office measurement and mean 24-hour systolic blood pressure ≥130 mmHg and <160 mmHg by ambulatory monitoring
- Ability to understand and comply with study procedures
You will not qualify if you...
- Known history of secondary hypertension
- Orthostatic hypotension
- Laboratory test results outside normal ranges at screening
- Evidence of liver disease
- Medical condition requiring RAAS inhibitor treatment other than hypertension
- History of congestive heart failure
- Current or past intolerance to ACE inhibitors and/or ARBs
- Significant cardiac arrhythmias or high-grade AV block within 6 months before screening
- Acute myocardial infarction, unstable angina, PCI, or CABG within 12 months before screening
- History of ischemic or hemorrhagic stroke or transient ischemic attack at any time before screening
- Other protocol-defined inclusion/exclusion criteria may apply
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 84 locations
1
SEC Clinical Research LLC
Andalusia, Alabama, United States, 36420
Actively Recruiting
2
UAB St Vincents
Birmingham, Alabama, United States, 35211
Actively Recruiting
3
Longwood Research
Huntsville, Alabama, United States, 35801
Actively Recruiting
4
The Center for Clinical Trials
Saraland, Alabama, United States, 36571
Actively Recruiting
5
Elite Clinical Studies
Phoenix, Arizona, United States, 85018
Actively Recruiting
6
Synexus Clinical Research US Inc
Tucson, Arizona, United States, 85741
Actively Recruiting
7
NICRs Research Center
Garden Grove, California, United States, 92844
Actively Recruiting
8
Valiance Clinical Research
Huntington Park, California, United States, 90255
Actively Recruiting
9
Downtown L A Research Center Inc
Los Angeles, California, United States, 90017
Actively Recruiting
10
Clinical Trials Research Sacramento
Sacramento, California, United States, 95821-2134
Active, Not Recruiting
11
Encompass Clinical Research
Spring Valley, California, United States, 91978-1522
Actively Recruiting
12
Clinical Research of Brandon LLC
Brandon, Florida, United States, 33511
Actively Recruiting
13
ALL Medical Research LLC
Cooper City, Florida, United States, 33024
Actively Recruiting
14
National Research Institute
Hialeah, Florida, United States, 33013
Actively Recruiting
15
Cen Exel RCA
Hollywood, Florida, United States, 33024
Actively Recruiting
16
East Coast Institute for Research
Jacksonville, Florida, United States, 32216
Actively Recruiting
17
Entrust Clinical Research
Miami, Florida, United States, 33176
Actively Recruiting
18
Inpatient Research Clinical LLC
Miami Lakes, Florida, United States, 33014
Actively Recruiting
19
Inpatient Research Clinical LLC
Miami Lakes, Florida, United States, 33014
Actively Recruiting
20
Suncoast Clinical Research
New Port Richey, Florida, United States, 34452
Actively Recruiting
21
Renstar Medical Research
Ocala, Florida, United States, 34471
Actively Recruiting
22
American Research Centers of FL
Pembroke Pines, Florida, United States, 33027
Actively Recruiting
23
Cen Exel FCR
Tampa, Florida, United States, 33613
Actively Recruiting
24
Cardiology Partners Clinical Research Institute
Wellington, Florida, United States, 33449
Actively Recruiting
25
Centricity Research
Columbus, Georgia, United States, 31904
Actively Recruiting
26
Javara Research
Fayetteville, Georgia, United States, 30214
Actively Recruiting
27
Javara Research
Fayetteville, Georgia, United States, 30214
Actively Recruiting
28
Velocity Clinical Research
Savannah, Georgia, United States, 31406
Actively Recruiting
29
Solaris Clinical Research
Meridian, Idaho, United States, 83646
Actively Recruiting
30
Cedar Crosse Research Ct
Chicago, Illinois, United States, 60607
Actively Recruiting
31
Eagle Clinical Research
Chicago, Illinois, United States, 60621
Actively Recruiting
32
Synexus Clinical Research US
Evansville, Indiana, United States, 47714
Actively Recruiting
33
Velocity Clin Research Sioux City
Sioux City, Iowa, United States, 51106
Actively Recruiting
34
Alliance for Multispecialty Research
Wichita, Kansas, United States, 67207
Actively Recruiting
35
Velocity Clinical Res Baton Rouge
Baton Rouge, Louisiana, United States, 70809
Actively Recruiting
36
Southern Clin Research Clinic
Zachary, Louisiana, United States, 70791
Actively Recruiting
37
Ascension Saint Agnes Heart Care
Baltimore, Maryland, United States, 21229
Actively Recruiting
38
Anderson Medical Research
Ft. Washington, Maryland, United States, 20744
Actively Recruiting
39
Capitol Cardiology Associates
Lanham, Maryland, United States, 20706
Actively Recruiting
40
AA Medical Research Center
Flint, Michigan, United States, 48504
Actively Recruiting
41
Oakland Medical Research Center
Troy, Michigan, United States, 48085
Actively Recruiting
42
Trinity Health Michigan Heart
Ypsilanti, Michigan, United States, 48197
Actively Recruiting
43
Synexus Clinical Research US Inc
Richfield, Minnesota, United States, 55432
Actively Recruiting
44
David M Headley Clinic
Port Gibson, Mississippi, United States, 39150
Withdrawn
45
Healthcare Research Network II LLC
Hazelwood, Missouri, United States, 63042
Actively Recruiting
46
Jefferson City Medical Group
Jefferson City, Missouri, United States, 65109
Actively Recruiting
47
Clin Rsrch Consult a JCCT Company
Kansas City, Missouri, United States, 64111
Actively Recruiting
48
Velocity Clin at Pioneer Heart Inst
Lincoln, Nebraska, United States, 68506
Actively Recruiting
49
AMR Las Vegas
Las Vegas, Nevada, United States, 89119
Actively Recruiting
50
CenExel HRI
Berlin, New Jersey, United States, 08009
Actively Recruiting
51
Velocity Clinical Research
Binghamton, New York, United States, 13905
Actively Recruiting
52
Novant Health Heart Vas Inst
Charlotte, North Carolina, United States, 28204
Actively Recruiting
53
Monroe Biomedical Research
Monroe, North Carolina, United States, 28112
Actively Recruiting
54
Burke Primary Care
Morganton, North Carolina, United States, 28655
Actively Recruiting
55
Accellacare of Rocky Mount
Rocky Mount, North Carolina, United States, 27804
Actively Recruiting
56
Accellacare of Salisbury
Salisbury, North Carolina, United States, 28144
Actively Recruiting
57
CR Services Acquisition US
Columbus, Ohio, United States, 43213
Actively Recruiting
58
Conrad Clinical Research
Edmond, Oklahoma, United States, 73013
Actively Recruiting
59
Velocity Clinical Research Medford
Medford, Oregon, United States, 97504
Actively Recruiting
60
TCV Clinical Studies
Linwood, Pennsylvania, United States, 19061
Actively Recruiting
61
Velocity Clinical Research
Union, South Carolina, United States, 29379
Actively Recruiting
62
Clinical Neuroscience Solutions Inc
Memphis, Tennessee, United States, 38119
Actively Recruiting
63
Velocity Clinical Research Austin
Austin, Texas, United States, 78759
Actively Recruiting
64
North Hills Medical Research Inc
Bedford, Texas, United States, 76021
Actively Recruiting
65
Synergy Group Medical LLC
Houston, Texas, United States, 77061
Actively Recruiting
66
Biopharma Informatic
Katy, Texas, United States, 77479
Actively Recruiting
67
Synergy Groups Medical LLC
Missouri City, Texas, United States, 77459
Actively Recruiting
68
Sun Research Institute
San Antonio, Texas, United States, 78205
Actively Recruiting
69
Clinical Trials of Texas
San Antonio, Texas, United States, 78229
Actively Recruiting
70
AMR Layton
Layton, Utah, United States, 84041
Actively Recruiting
71
Manassas Clinical Research Center
Manassas, Virginia, United States, 20110
Actively Recruiting
72
Dominion Medical Associates
Richmond, Virginia, United States, 23219
Actively Recruiting
73
Centricity Research Suffolk Fam Med
Suffolk, Virginia, United States, 23435
Actively Recruiting
74
MultiCare Ins Research Innovation
Puyallup, Washington, United States, 98372
Actively Recruiting
75
Velocity Clinical Research Spokane
Spokane, Washington, United States, 99218
Actively Recruiting
76
Novartis Investigative Site
Suita, Osaka, Japan, 5650853
Actively Recruiting
77
Novartis Investigative Site
Chuo Ku, Tokyo, Japan, 103-0027
Actively Recruiting
78
Novartis Investigative Site
Chuo Ku, Tokyo, Japan, 104-0031
Actively Recruiting
79
Novartis Investigative Site
Chuo-ku, Tokyo, Japan, 1030027
Actively Recruiting
80
Novartis Investigative Site
Shinjuku Ku, Tokyo, Japan, 160-0008
Actively Recruiting
81
Novartis Investigative Site
Singapore, Singapore, 119074
Actively Recruiting
82
Novartis Investigative Site
Singapore, Singapore, 308433
Actively Recruiting
83
Novartis Investigative Site
Singapore, Singapore, 519466
Actively Recruiting
84
Novartis Investigative Site
Singapore, Singapore, 529889
Actively Recruiting
Research Team
N
Novartis Pharmaceuticals
CONTACT
N
Novartis Pharmaceuticals
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
6
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here