Actively Recruiting
A Study of the Impact of Endocrine Therapy on Surgical Outcomes in People With Breast Cancer
Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-03-19
176
Participants Needed
7
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to look at how effective neoadjuvant (before surgery) endocrine therapy (NET) is in participants with invasive lobular carcinoma (ILC) who have breast-conserving surgery (BCS). The main purpose of the study is to see if NET reduces the chance of having cancer cells at the edges of tissue removed during surgery (positive margins).
CONDITIONS
Official Title
A Study of the Impact of Endocrine Therapy on Surgical Outcomes in People With Breast Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Written informed consent by participant or legally authorized representative
- Postmenopausal women aged 6550 years with biopsy-proven cT2-T3 N0-1 invasive lobular carcinoma
- Tumors must be estrogen receptor positive (ER+) with at least 10% immunoreactive tumor nuclei
- Tumors must be HER2 negative demonstrated by specific immunohistochemistry or hybridization assays
- Participants must be medically fit and have chosen to undergo breast-conserving surgery at enrollment
You will not qualify if you...
- Prior breast cancer on the same side (ipsilateral)
- Advanced regional disease (cN2/cN3) or stage 4 disease
- Patients recommended for neoadjuvant chemotherapy by their oncologist
- Not candidates for definitive breast surgery due to inoperable or stage 4 disease
- Allergy to gadolinium preventing use of breast MRI
AI-Screening
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Trial Site Locations
Total: 7 locations
1
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
2
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)
Middletown, New Jersey, United States, 07748
Actively Recruiting
3
Memorial Sloan Kettering Bergen (Limited Protocol Activities)
Montvale, New Jersey, United States, 07645
Actively Recruiting
4
Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities)
Commack, New York, United States, 11725
Actively Recruiting
5
Memorial Sloan Kettering Westchester (Limited Protocol Activities)
Harrison, New York, United States, 10604
Actively Recruiting
6
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
New York, New York, United States, 10065
Actively Recruiting
7
Memorial Sloan Kettering Nassau (Limited Protocol Activities)
Uniondale, New York, United States, 11553
Actively Recruiting
Research Team
A
Anita Mamtani, MD
CONTACT
G
George Plitas, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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