Actively Recruiting
Study of INCA036978 in Participants With Myeloproliferative Neoplasms
Led by Incyte Corporation · Updated on 2026-04-15
218
Participants Needed
47
Research Sites
212 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will be conducted to determine the safety, tolerability, dose-limiting toxicity (DLT)s, and maximum tolerated dose (MTD) and/or recommended dose for expansion (RDE)s of INCA036978 administered as monotherapy and in combination with a standard disease-directed therapy.
CONDITIONS
Official Title
Study of INCA036978 in Participants With Myeloproliferative Neoplasms
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Life expectancy greater than 6 months
- Willingness to undergo pretreatment and limited on-study bone marrow biopsies and aspirates as appropriate
- Diagnosis of myelofibrosis, polycythemia vera, or essential thrombocythemia as defined in the protocol
You will not qualify if you...
- Having any blood cancer other than myelofibrosis, polycythemia vera, or essential thrombocythemia
- History of any malignancy within the 3 years before enrollment
- Presence of acute or chronic hepatitis B, active hepatitis C, known HIV, or tuberculosis infection
- Clinically significant or uncontrolled heart disease
- Prior allogeneic stem-cell transplantation or planned transplantation within 6 months
- Laboratory test results outside protocol-defined ranges
- History of major bleeding or thrombosis within 3 months before enrollment
- Presence of chronic or active infection requiring systemic treatment
- Treatment with any myeloproliferative neoplasm-directed therapy within protocol-defined timing before study drug
- Radiation therapy within 28 days before the first dose of study treatment
- Other protocol-defined inclusion or exclusion criteria may apply
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 47 locations
1
University of Alabama At Birmingham
Birmingham, Alabama, United States, 35233
Not Yet Recruiting
2
City of Hope-Lennar Foundation Cancer Center
Irvine, California, United States, 92618
Not Yet Recruiting
3
Usc Norris Comprehensive Cancer Center
Los Angeles, California, United States, 90033
Not Yet Recruiting
4
UCLA Medical Hematology & Oncology
Los Angeles, California, United States, 90095
Not Yet Recruiting
5
Yale Cancer Center
New Haven, Connecticut, United States, 06510
Not Yet Recruiting
6
University of Miami
Miami, Florida, United States, 33136
Not Yet Recruiting
7
Moffitt Cancer Center
Tampa, Florida, United States, 33612
Not Yet Recruiting
8
Winship Cancer Institute of Emory University
Atlanta, Georgia, United States, 30322
Not Yet Recruiting
9
John Hopkins Hospital
Baltimore, Maryland, United States, 21287
Not Yet Recruiting
10
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Not Yet Recruiting
11
Washington University School of Medicine
St Louis, Missouri, United States, 63108
Not Yet Recruiting
12
Mount Sinai School of Medicine
New York, New York, United States, 10029
Not Yet Recruiting
13
Weill Cornell Medicine
New York, New York, United States, 10065
Not Yet Recruiting
14
University of North Carolina At Chapel Hill
Chapel Hill, North Carolina, United States, 27514
Not Yet Recruiting
15
Levine Cancer Institute
Charlotte, North Carolina, United States, 28204
Not Yet Recruiting
16
Duke University Medical Center, Department of Hematologic Malignancies and Cellular Therapy
Durham, North Carolina, United States, 27705
Not Yet Recruiting
17
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Not Yet Recruiting
18
Ohio State University
Columbus, Ohio, United States, 43210
Not Yet Recruiting
19
Tristar Bmt/Tcto
Nashville, Tennessee, United States, 37203
Not Yet Recruiting
20
University of Texas M. D. Anderson Cancer Center
Houston, Texas, United States, 77030
Not Yet Recruiting
21
Huntsman Cancer Institute
Salt Lake City, Utah, United States, 84112
Not Yet Recruiting
22
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Not Yet Recruiting
23
Concord General Repatriation Hospital
Concord, New South Wales, Australia, 02139
Not Yet Recruiting
24
Royal North Shore Hospital
St Leonards, New South Wales, Australia, 02065
Not Yet Recruiting
25
Icon Cancer Centre
Auchenflower, Queensland, Australia, 04066
Actively Recruiting
26
Epworth Health Care
East Melbourne, Victoria, Australia, 03002
Actively Recruiting
27
Linear Clinical Research
Nedlands, Western Australia, Australia, 06009
Actively Recruiting
28
Centre Hospitalier Universitaire (Chu) de Liege
Liège, Belgium, 04000
Not Yet Recruiting
29
AZ DELTA
Roeselare, Belgium, 08800
Not Yet Recruiting
30
Hopital Maisonneuve-Rosemont, Montreal, Qc
Montreal, Quebec, Canada, H1T 2M4
Not Yet Recruiting
31
Institut Bergonie
Bordeaux, France, 33076
Not Yet Recruiting
32
Hospital Saint Louis
Paris, France, 75010
Not Yet Recruiting
33
Institut Gustave Roussy
Villejuif, France, 94805
Not Yet Recruiting
34
University Medical Center Rwth Aachen
Aachen, Germany, D-52074
Not Yet Recruiting
35
Charite Universitaetsmedizin Berlin - Campus Charite Mitte
Berlin, Germany, 10117
Not Yet Recruiting
36
Universitatklinikum Freiburg
Freiburg im Breisgau, Germany, 79106
Not Yet Recruiting
37
Universitatsmedizin Der Johannes Gutenberg-Universitat Mainz Iii
Mainz, Germany, 55131
Not Yet Recruiting
38
Aou Policlinico S. Orsola-Malpighi
Bologna, Italy, 40138
Not Yet Recruiting
39
Fondazione Irccs Ca' Granda - Ospedale Maggiore Policlinico
Milan, Italy, 20122
Not Yet Recruiting
40
A. Gemelli University Hospital, Catholic University of the Sacred Heart
Roma, Italy, 00168
Not Yet Recruiting
41
Azienda Sanitaria Universitaria Friuli Centrale Asu Fc
Udine, Italy, 33100
Not Yet Recruiting
42
Hospital Universitari Germans Trias I Pujol
Badalona, Spain, 08916
Not Yet Recruiting
43
Hospital Universitario de Gran Canaria Dr. Negrin
Las Palmas de Gran Canaria, Spain, 35010
Not Yet Recruiting
44
Hospital Universitario 12 de Octubre
Madrid, Spain, 28041
Not Yet Recruiting
45
Guy'S Hospital - Guy'S & St Thomas' Nhs Foundation Trust
London, United Kingdom, SE1 9RT
Not Yet Recruiting
46
Nottingham University Hospitals
Nottingham, United Kingdom, NG5 1PB
Not Yet Recruiting
47
University of Oxford
Oxford, United Kingdom, OX3 7LE
Not Yet Recruiting
Research Team
I
Incyte Corporation Call Center (US)
CONTACT
I
Incyte Corporation Call Center (ex-US)
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
4
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