Actively Recruiting
A Study of INCB123667 in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression
Led by Incyte Corporation · Updated on 2026-05-08
160
Participants Needed
82
Research Sites
101 weeks
Total Duration
On this page
Sponsors
I
Incyte Corporation
Lead Sponsor
E
ENGOT Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study will evaluate the safety and efficacy of INCB123667 in Participants With Platinum-Resistant Ovarian Cancer (PROC) With Cyclin E1 Overexpression.
CONDITIONS
Official Title
A Study of INCB123667 in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histological diagnosis of a high-grade serous epithelial ovarian, fallopian tube, or primary peritoneal cancer
- Platinum-resistant disease: participants with 1 line of platinum therapy must have had at least 4 cycles; those with 2 to 4 lines must have progressed on or within 6 months after last platinum dose
- Willingness to undergo a pretreatment biopsy; fresh biopsy preferred or archival sample not older than 5 years
- Received at least 1 and no more than 4 prior lines of systemic therapy after initial diagnosis, with single-agent therapy appropriate next step
- Must have received bevacizumab unless medically contraindicated
- If tumor tests positive for FRα, must have received mirvetuximab soravtansine unless medically contraindicated
You will not qualify if you...
- Endometrioid, clear cell, mucinous, or sarcomatous histology or mixed tumors with these histologies; low-grade or borderline ovarian cancer
- Primary platinum-refractory disease: no response or progression on/within 3 months after first-line platinum therapy
- Tumor positive for FRα but no mirvetuximab soravtansine received except for medical contraindication
- Clinically significant or uncontrolled cardiac disease within 6 months before first study drug dose
- Known active CNS metastases or carcinomatous meningitis
- Known additional malignancy that is progressing or requires active treatment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 82 locations
1
Usa Health Mitchell Cancer Institute
Mobile, Alabama, United States, 36604
Not Yet Recruiting
2
Uams Winthrop P Rockefeller Cancer Institute
Little Rock, Arkansas, United States, 72205
Not Yet Recruiting
3
University of California, Los Angeles Medical Center
Los Angeles, California, United States, 90024-6995
Actively Recruiting
4
Scripps Healthscripps Mercy Hospital Prebys Cancer Center
San Diego, California, United States, 92103
Actively Recruiting
5
Medstar Georgetown University Hospital
Washington D.C., District of Columbia, United States, 20010
Actively Recruiting
6
Florida Cancer Specialists & Research Institute
Fort Myers, Florida, United States, 33901
Actively Recruiting
7
Mayo Clinic
Jacksonville, Florida, United States, 32224
Withdrawn
8
Sylvester Comprehensive Cancer Center
Miami, Florida, United States, 33136
Not Yet Recruiting
9
Mount Sinai Comprehensive Cancer Center
Miami Beach, Florida, United States, 33140
Actively Recruiting
10
Florida Cancer Specialists & Research Institute
West Palm Beach, Florida, United States, 33401
Actively Recruiting
11
Northeast Georgia Medical Center Gainesville
Gainesville, Georgia, United States, 30501
Actively Recruiting
12
Parkview Research Center
Fort Wayne, Indiana, United States, 46845
Actively Recruiting
13
University of Iowa Hospital and Clinics
Iowa City, Iowa, United States, 52242-1009
Not Yet Recruiting
14
Norton Cancer Institute
Louisville, Kentucky, United States, 40207
Actively Recruiting
15
Trials365, Llc
Shreveport, Louisiana, United States, 71103
Actively Recruiting
16
Greater Baltimore Medical Center
Baltimore, Maryland, United States, 21204
Actively Recruiting
17
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
18
Umass Memorial Medical Center, Inc.
Worcester, Massachusetts, United States, 01605
Not Yet Recruiting
19
University of Michigan Cancer Center
Ann Arbor, Michigan, United States, 48109
Withdrawn
20
University of Michigan Health System
Ann Arbor, Michigan, United States, 48109
Not Yet Recruiting
21
Minnesota Oncology-Minneapolis
Minneapolis, Minnesota, United States, 55404
Actively Recruiting
22
University of Mississippi Medical Center
Jackson, Mississippi, United States, 39216
Not Yet Recruiting
23
Washington University
St Louis, Missouri, United States, 63110
Actively Recruiting
24
St. Vincent Regional Hospital - West End Clinic
Billings, Montana, United States, 59106
Actively Recruiting
25
Nebraska Methodist Hospital
Omaha, Nebraska, United States, 68114
Actively Recruiting
26
John Theurer Cancer Center, Hackensack University Medical Center
Hackensack, New Jersey, United States, 07601
Actively Recruiting
27
Laura and Isaac Perlmutter Cancer Center
New York, New York, United States, 10016
Actively Recruiting
28
University of Rochester, James P. Wilmot Cancer Center
Rochester, New York, United States, 14642
Withdrawn
29
State University of New York Upstate Medical Unive
Syracuse, New York, United States, 13210
Not Yet Recruiting
30
Oncology Hematology Care, Inc
Cincinnati, Ohio, United States, 45242
Actively Recruiting
31
The Mark H Zangmeister Cancer Center Ohio
Columbus, Ohio, United States, 43219
Actively Recruiting
32
The Ohio State University Wexner Medical Center Division of Gynecologic Oncology
Hilliard, Ohio, United States, 43026
Not Yet Recruiting
33
Penn State College of Medicine
Hershey, Pennsylvania, United States, 17033
Not Yet Recruiting
34
Asplundh Cancer Pavilion - Thomas Jefferson
Willow Grove, Pennsylvania, United States, 19090
Withdrawn
35
Medical University of South Carolina
Charleston, South Carolina, United States, 29425
Not Yet Recruiting
36
Texas Oncology-Austin Center
Austin, Texas, United States, 78731
Actively Recruiting
37
Houston Methodist Cancer Center
Houston, Texas, United States, 77030
Withdrawn
38
Texas Oncology-San Antonio Medical Center Pharmacy
San Antonio, Texas, United States, 78229
Actively Recruiting
39
Texas Oncology-Tyler
Tyler, Texas, United States, 75702
Actively Recruiting
40
Utah Cancer Specialists
Salt Lake City, Utah, United States, 84106
Actively Recruiting
41
Virginia Cancer Specialists
Fairfax, Virginia, United States, 22031
Actively Recruiting
42
Carilion Clinic
Roanoke, Virginia, United States, 24016-4962
Actively Recruiting
43
West Virginia University
Morgantown, West Virginia, United States, 26506
Actively Recruiting
44
Froedtert & the Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Not Yet Recruiting
45
Blacktown Cancer & Haematology Centre-Blacktown Hospital
Blacktown, New South Wales, Australia, 02148
Not Yet Recruiting
46
Concord General Repatriation Hospital
Concord, New South Wales, Australia, 02139
Not Yet Recruiting
47
Burnside War Memorial Hospital - the Brian Fricker Oncology Centre
Adelaide, South Australia, Australia, 05065
Not Yet Recruiting
48
Hobart Hospital-Royal Hobart Hospital
Hobart, Tasmania, Australia, 07000
Actively Recruiting
49
Cancer Research Sa (Crsa)
Adelaide, Australia, 05000
Actively Recruiting
50
Southern Oncology Clinical Research Unit
South Australia, Australia, 05042
Withdrawn
51
Hopital Universitaire de Bruxelles (Hub) - Institut Jules Bordet
Brussels, Belgium, 01070
Actively Recruiting
52
Cliniques Universitaires St Luc Ucl
Brussels, Belgium, B-1200
Actively Recruiting
53
Az Groeninge
Kortrijk, Belgium, 08500
Actively Recruiting
54
Universitair Ziekenhuis Leuven
Leuven, Belgium, 03000
Actively Recruiting
55
Chu Liege
Liège, Belgium, 04000
Not Yet Recruiting
56
Hyogo Cancer Center
Akashi-shi, Japan, 673-8558
Actively Recruiting
57
Saitama Medical University International Medical Center
Hidaka-shi, Japan, 350-1298
Actively Recruiting
58
The Cancer Institute Hospital of Jfcr
Kōtoku, Japan, 135-8550
Actively Recruiting
59
Kurume University Hospital
Kurume, Japan, 830-0011
Actively Recruiting
60
Shikoku Cancer Center
Matsuyama, Japan, 791-0280
Actively Recruiting
61
Hokkaido University Hospital
Sapporo, Japan, 060-8648
Actively Recruiting
62
Shizuoka Cancer Center
Sunto-gun, Japan, 411-8777
Actively Recruiting
63
Panoncology Trials
San Juan, PR, Puerto Rico, 00935
Actively Recruiting
64
Hospital Universitario Vall D'Hebron
Barcelona, Spain, 08035
Actively Recruiting
65
Hospital Clinic de Barcelona
Barcelona, Spain, 08036
Actively Recruiting
66
Instituto Catalan de Oncologia - Hospital Duran I Reynals
Barcelona, Spain, 08908
Not Yet Recruiting
67
Hospital Universitario Reina Sofia
Córdoba, Spain, 14004
Not Yet Recruiting
68
Institut Catala D'Oncologia Girona
Girona, Spain, 17007
Actively Recruiting
69
Clinica Universidad de Navarra - Sede Madrid
Madrid, Spain, 28027
Actively Recruiting
70
Hospital Universitario La Paz
Madrid, Spain, 28046
Actively Recruiting
71
Hospital Universitario Virgen de La Arrixaca
Murcia, Spain, 30120
Actively Recruiting
72
Fundacion Instituto Valenciano de Oncologia
Valencia, Spain, 46009
Actively Recruiting
73
Hospital Clinico Universitario de Valencia (Instituto de Investigacion Sanitaria Incliva)
Valencia, Spain, 46010
Actively Recruiting
74
Istituto Oncologico Della Svizzera Italiana (Iosi) Di Bellinzona
Bellinzona, Switzerland, 06500
Not Yet Recruiting
75
Kantonsspital Graubunden
Chur, Switzerland, 07000
Not Yet Recruiting
76
Geneva University Hospitals-Hug
Geneva, Switzerland, 01211
Not Yet Recruiting
77
Centre Hospitalier Universitaire Vaudois Lausanne (Chuv) - Centre Du Cancer Lausanne-Batiment Hospit
Lausanne, Switzerland, 01011
Not Yet Recruiting
78
St Bartholomew'S Hospital
London, United Kingdom, EC1A 7BE
Not Yet Recruiting
79
Guy'S Hospital - Guy'S & St Thomas' Nhs Foundation Trust
London, United Kingdom, SE1 9RT
Actively Recruiting
80
Royal Marsden Hospital (Sutton) - Royal Marsden Nhs Foundation Trust
London, United Kingdom, SM2 5PT
Actively Recruiting
81
Hammersmith Hospital - Imperial College Healthcare Nhs Trust
London, United Kingdom, W12 0HS
Actively Recruiting
82
The Christie Nhs Foundation Trust
Manchester Greater, United Kingdom, M204BX
Actively Recruiting
Research Team
I
Incyte Corporation Call Center (US)
CONTACT
I
Incyte Corporation Call Center (ex-US)
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
3
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