Observational Study on Adrenal Insufficiency After Surgery in Adults with Primary Aldosteronism With or Without Autonomous Cortisol Secretion

What this Trial Is About

Researchers are studying the occurrence of adrenal insufficiency after surgery in patients with Primary Aldosteronism PA, both with and without autonomous cortisol secretion ACS. The study aims to understand how often this condition occurs, how long it takes for adrenal function to recover after surgery, and to identify clinical features and predictors for patients who may need hormone replacement therapy after the operation. This research is conducted as a prospective, single-center observational study. The study involves patients diagnosed with PA or ACS who have undergone unilateral adrenal surgery. Participants complete an adrenocorticotropic hormone ACTH stimulation test the day after surgery, with additional ACTH tests performed 1 or 4 weeks later for those showing signs of adrenal insufficiency. The study includes groups of patients with PA alone, PA concurrent with ACS, and ACS alone, all undergoing surgical treatment and the ACTH stimulation test. Participants will be monitored through scheduled ACTH stimulation tests shortly after surgery and during follow-up visits at 1 and 4 weeks, as well as 3 and 6 months post-surgery. Researchers will assess the incidence of adrenal insufficiency immediately after surgery, track recovery times over the following months, and evaluate clinical characteristics linked to the need for hormone replacement therapy. The studys total duration includes these follow-up periods to gather detailed data on patient outcomes and recovery.

Study on the Incidence of Adrenal Insufficiency After Surgery in Primary Aldosteronism Patients Concurrent With or Without Autonomous Cortisol Secretion