Actively Recruiting
Study of Individuals Affected With Hypoplasminogenemia
Led by Indiana Hemophilia &Thrombosis Center, Inc. · Updated on 2025-08-28
100
Participants Needed
30
Research Sites
434 weeks
Total Duration
On this page
Sponsors
I
Indiana Hemophilia &Thrombosis Center, Inc.
Lead Sponsor
F
Fondazione Angelo Bianchi Bonomi
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is an Investigator initiated retrospective and prospective single cohort study. The study will utilize an international registry and develop a specimen biobank to provide an improved understanding of the natural history of hyposplasminogenemia, to elucidate the heterogeneity of phenotypic expression, identify markers to predict disease course, and inform improved therapeutic modalities
CONDITIONS
Official Title
Study of Individuals Affected With Hypoplasminogenemia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed informed consent and assent as applicable
- Males or females with type 1 plasminogen deficiency diagnosed locally with plasminogen activity levels below 50%
- First-degree family members of a person diagnosed with type 1 plasminogen deficiency (parents, siblings, half-siblings)
- All ages included
- Available clinical history and treatment for at least 1 year before joining, except for infants under 1 year old
- Willingness to provide samples for analysis including DNA and plasma
- Willingness to participate in prospective follow-up for up to 3 years
You will not qualify if you...
- Previous organ transplant recipient
- Presence of psychiatric, mental, or other medical disorders that impair ability to give informed consent or comply with the study
- Refusal to provide informed consent
- Special patient populations such as prisoners or those deemed medically or cognitively unsuitable by their physician
- Inability to obtain a blood sample due to poor or limited venous access
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 30 locations
1
The University of Alabama (UAB)
Birmingham, Alabama, United States, 35233
Actively Recruiting
2
Rush University Medical Center
Chicago, Illinois, United States, 60612
Actively Recruiting
3
Indiana Hemophila @Thrombosis Center
Indianapolis, Indiana, United States, 46260
Actively Recruiting
4
University of Minnesota, Pediatric Hem/Onc & Cancer Survivorship Program
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
5
Stony Brook University | Stony Brook Medicine
East Setauket, New York, United States, 11733
Actively Recruiting
6
SUNY Upstate Medical University, Pediatric Hematology/Oncology
Syracuse, New York, United States, 13210
Actively Recruiting
7
Wake Forest University
Winston-Salem, North Carolina, United States, 27157
Actively Recruiting
8
Hemophilia Center of Western Pennsylvania
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
9
Vanderbilt Children's Hematology-Oncology
Nashville, Tennessee, United States, 37232
Completed
10
Cook Children's Medical Center
Forth Worth, Texas, United States, 76104
Actively Recruiting
11
The University of Texas Health Science Center at Houston
Houston, Texas, United States, 77030
Completed
12
Seattle Children's Hospital
Seattle, Washington, United States, 98105-3901
Actively Recruiting
13
Hospital Britanico Buenos Aires
Buenos Aires, Argentina, C1280
Actively Recruiting
14
Murdoch Children's Research Institute, The Royal Children's Hospital
Melbourne, Victoria, Australia, 3052
Actively Recruiting
15
Children's Health Queensland Hospital and Health Service
South Brisbane, Australia, QLD 4101
Actively Recruiting
16
Medical University of Innsbruck, University Clinic for Pediatrics and Adolescent Medicine
Innsbruck, Austria, A-6020
Actively Recruiting
17
Windsor Regional Hospital
Windsor, Ontario, Canada, N8W 1L9
Actively Recruiting
18
CHU Sainte-Justine
Montreal, Quebec, Canada, H3T 1C5
Actively Recruiting
19
CHU de Québec Université Laval
Québec, Quebec, Canada, A0121
Actively Recruiting
20
University of Saskatchewan
Saskatoon, Canada, SK S7N 0W8
Actively Recruiting
21
Alexandra Hospital, Athens, Hematology Department
Athens, Greece, 11528
Actively Recruiting
22
Safra's Children Hospital, Sheba Medical Center
Tel Aviv, Israel
Actively Recruiting
23
Angelo Bianchi Bonomi Hemophilia and Thrombosis Center,
Milan, Italy, 20122
Actively Recruiting
24
University Hospital of Padova
Padua, Italy, 35100
Actively Recruiting
25
Faculty of Medicine, Chiang Mai University
Chiang Mai, Thailand, 50200
Actively Recruiting
26
Dokuz Eylul University pediatric Pulmonology, Allergy and Clinical Immunology
Izmir, Balçova, Turkey (Türkiye), 35330
Active, Not Recruiting
27
Istanbul Üniversitesi Onkoloji Enstitüsü
Istanbul, Turkey (Türkiye), 34093
Actively Recruiting
28
Istanbul University Cerrahpsasa, Cerrahpsasa Medical Faculty Pediatric Hematology and Oncology Department
Istanbul, Turkey (Türkiye), 34098
Active, Not Recruiting
29
Yuzuncu Yil University Faculty of Medicine Department of Ophthalmology
Van, Turkey (Türkiye), 65040
Actively Recruiting
30
Royal Free Hospital, Royal Free London NHS Foundation Trust
London, United Kingdom
Actively Recruiting
Research Team
A
Amy D Shapiro, MD
CONTACT
C
Charles Nakar, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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