Actively Recruiting
A Study of Initiation Timing of VTE Prevention After Colorectal Cancer Surgery
Led by RenJi Hospital · Updated on 2024-08-09
914
Participants Needed
1
Research Sites
69 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This project intends to conduct a single-center, prospective, observational cohort study to explore the impact of the timing of drug prophylaxis on the risk of postoperative bleeding and the preventive effect of VTE in the prevention and management of postoperative venous thromboembolism (VTE) after colorectal cancer (CRC) surgery in Chinese population, and to determine its application and promotion value. The research results of this project can provide useful reference for optimizing the prevention and management of VTE after CRC operation.
CONDITIONS
Official Title
A Study of Initiation Timing of VTE Prevention After Colorectal Cancer Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age > 18 years old
- Diagnosed with colorectal cancer at cTMN stage cT1-2, N0 or cT3, N0 or any cT, N1-2
- Able to receive radical colorectal cancer surgery (laparoscopic or open), with expected operation time >45 minutes
- Expected postoperative survival time longer than 6 months
- Patient or guardian agrees to the study and signs informed consent
You will not qualify if you...
- Renal insufficiency with creatinine clearance <30 mL/min or hepatic insufficiency with ALT >3 times the upper limit of normal
- Colorectal cancer with cTMN stage cT4 and/or unresectable local lesions, including extensive lateral pelvic wall invasion, external iliac vascular involvement, tumor invasion into the great sciatic notch, sciatic nerve invasion, or invasion of the second sacrum level and above
- Known allergy to low molecular weight heparin, narcotic drugs, or radiocontrast agents
- Presence of systemic bleeding disorders or active bleeding conditions such as active peptic ulcer, uncontrolled hypertension, cerebral thrombosis, cerebral hemorrhage, or neurosurgical history within 6 months
- Known brain metastases, endocarditis, or history of heparin-induced thrombocytopenia
- Venous thromboembolism occurred within 3 months before surgery
- Use of heparin or oral anticoagulant therapy within 5 days before surgery
- Women who are pregnant or breastfeeding
- Any other condition deemed unsuitable for anticoagulant therapy by the investigator
AI-Screening
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Trial Site Locations
Total: 1 location
1
Department of Gastrointestinal Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China, 200127
Actively Recruiting
Research Team
M
Meng Hu, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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