Actively Recruiting
Phase II Study of Hemithoracic Intensity-Modulated Pleural Radiation Therapy (IMPRINT) for Patients With Pleural Metastases From Thymic Malignancies
Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-05-06
36
Participants Needed
7
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating hemithoracic intensity-modulated pleural radiation therapy (IMPRINT) to determine if it is a safe treatment option with minimal side effects for people with thymic malignancies that have spread to the lining of the lungs and chest. The study also aims to assess whether this radiation therapy is effective against cancer in these patients. This is a Phase II clinical trial sponsored by Memorial Sloan Kettering Cancer Center. Participants will receive radiation therapy over about 6 weeks, with a total dose of 50.4 Gy given in 28 sessions. There is an option for a higher dose to areas of visible remaining cancer while protecting normal tissues. This treatment targets the affected hemithoracic pleura, the lining of one side of the chest. During the study, participants will be monitored for side effects such as radiation pneumonitis over two years. Researchers will also measure progression-free survival at 12 months to see how well the cancer is controlled. Participants will have regular assessments including lung function tests and kidney function evaluations to ensure safety, with study participation lasting for at least two years of follow-up.
CONDITIONS
Brief Title
A Study of Intensity-Modulated Pleural Radiation Therapy (IMPRINT) in People With Thymic Cancer That Has Spread to the Lining of the Lungs and Chest
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Provide written informed consent to participate on the study
- Have a confirmed diagnosis of thymic malignancy or thymic carcinoma
- Have radiologic or pathologic evidence of pleural metastases (stage IVA or recurrent disease)
- No evidence of cancer outside the chest or on the opposite side pleura or pericardium
- Be between 18 and 80 years old at consent
- Have Karnofsky performance status of 80% or higher
- Have lung function with DLCO greater than 40% predicted and FEV1 greater than or equal to 35% predicted
- Have kidney function with glomerular filtration rate of 50 mL/min/1.73 m2 or higher calculated by Cockcroft-Gault equation
You will not qualify if you...
- Continuous oxygen use
- Recent flare of myasthenia gravis needing new medication within 6 months
- Prior removal of kidney on the opposite side of pleural metastases
- Prior thoracic radiation that prevents hemithoracic pleural radiation therapy
- Undergoing extrapleural pneumonectomy surgery
- Acute congestive heart failure requiring hospitalization in past 30 days
- COPD requiring chronic oral steroid therapy over 10 mg prednisone daily
- Unstable angina or heart attack within last 3 months
- History of interstitial lung disease
- Pregnant or breastfeeding women
- Men or women not using effective contraception
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Approximately 6 weeks
Participants receive intensity-modulated pleural radiation therapy (IMPRINT) over approximately 6 weeks to target pleural metastases from thymic malignancies.
28 radiation therapy sessions
Trial Site Locations
Total: 7 locations
1
Memorial Sloan Kettering Basking Ridge (Limited protocol activities)
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
2
Memorial Sloan Kettering Monmouth (Limited protocol activities)
Middletown, New Jersey, United States, 07748
Actively Recruiting
3
Memorial Sloan Kettering Bergen (Limited protocol activities)
Montvale, New Jersey, United States, 07645
Actively Recruiting
4
Memorial Sloan Kettering Suffolk - Commack (Limited protocol activities)
Commack, New York, United States, 11725
Actively Recruiting
5
Memorial Sloan Kettering Westchester (Limited protocol activities)
Harrison, New York, United States, 10604
Actively Recruiting
6
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
7
Memorial Sloan Kettering Nassau (Limited protocol activities)
Rockville Centre, New York, United States, 11553
Actively Recruiting
Research Team
C
Charles Simone, MD
A
Andrew Pagano, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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