Actively Recruiting
A Study of Intensity-Modulated Pleural Radiation Therapy (IMPRINT) in People With Thymic Cancer That Has Spread to the Lining of the Lungs and Chest
Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-05-06
36
Participants Needed
7
Research Sites
257 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The researchers are doing this study to find out whether hemithoracic intensity-modulated pleural radiation therapy (IMPRINT) is a safe treatment that causes few or mild side effects in people with pleural metastases from thymic malignancies. The researchers will also look at whether hemithoracic IMPRINT is effective against participants' cancer.
CONDITIONS
Official Title
A Study of Intensity-Modulated Pleural Radiation Therapy (IMPRINT) in People With Thymic Cancer That Has Spread to the Lining of the Lungs and Chest
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Provide written informed consent to participate on the study
- Have a confirmed diagnosis of thymic malignancy, including thymic carcinoma
- Have radiologic or pathologic evidence of pleural metastases, including de novo stage IVA or recurrent pleural disease
- Have no evidence of metastatic disease outside the chest or disease on the opposite side of the chest lining or heart lining
- Be aged 18 to 79 years at the time of consent
- Have a Karnofsky performance status of 80% or higher
- Have preoperative or postoperative lung function tests showing DLCO greater than 40% predicted (corrected for hemoglobin) and FEV1 of 35% or higher (corrected for hemoglobin)
- Have a glomerular filtration rate (GFR) of at least 50 mL/min/1.73 m2 calculated by the Cockcroft-Gault equation
- May have an optional kidney function scan before radiation if needed to check kidney health
You will not qualify if you...
- Use continuous oxygen
- Have had an acute flare of myasthenia gravis requiring new medication in the past 6 months
- Have had removal of a kidney on the opposite side of the pleural metastases
- Have had prior thoracic radiation therapy that prevents hemithoracic pleural IMRT (prior thymic bed radiation or pleural SBRT allowed)
- Are undergoing extrapleural pneumonectomy surgery (other surgical approaches allowed)
- Have had acute congestive heart failure requiring hospitalization within the past 30 days
- Have COPD requiring chronic oral steroid therapy over 10 mg prednisone daily or equivalent (inhaled steroids allowed)
- Have unstable angina requiring hospitalization or heart attack within the last 3 months
- Have a history of interstitial lung disease
- Are pregnant or breastfeeding
- Are not using effective contraception if of childbearing potential
AI-Screening
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Trial Site Locations
Total: 7 locations
1
Memorial Sloan Kettering Basking Ridge (Limited protocol activities)
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
2
Memorial Sloan Kettering Monmouth (Limited protocol activities)
Middletown, New Jersey, United States, 07748
Actively Recruiting
3
Memorial Sloan Kettering Bergen (Limited protocol activities)
Montvale, New Jersey, United States, 07645
Actively Recruiting
4
Memorial Sloan Kettering Suffolk - Commack (Limited protocol activities)
Commack, New York, United States, 11725
Actively Recruiting
5
Memorial Sloan Kettering Westchester (Limited protocol activities)
Harrison, New York, United States, 10604
Actively Recruiting
6
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
7
Memorial Sloan Kettering Nassau (Limited protocol activities)
Rockville Centre, New York, United States, 11553
Actively Recruiting
Research Team
C
Charles Simone, MD
CONTACT
A
Andrew Pagano, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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