Actively Recruiting
A Study to Investigate ANS014004 in Participants With Locally Advanced or Metastatic Solid Tumors
Led by Avistone Biotechnology Co., Ltd. · Updated on 2026-04-17
63
Participants Needed
15
Research Sites
170 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a Phase 1, first-in-human, open-label, multi-center study with the aim of exploring the safety, tolerability, PK, and preliminary anti-tumor activity of ANS014004 as a single agent in participants with locally advanced or metastatic solid tumors.
CONDITIONS
Official Title
A Study to Investigate ANS014004 in Participants With Locally Advanced or Metastatic Solid Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1
- Life expectancy of at least 12 weeks
- Measurable disease according to RECIST v1.1 criteria
- Adequate organ and marrow function as specified in the protocol
- Presence of pathogenetic MET, ROS1, or NTRK alteration
You will not qualify if you...
- Active infections including tuberculosis, hepatitis B virus, hepatitis C virus, or HIV
- Known active or untreated central nervous system metastases
- Diagnosis of carcinomatous meningitis, meningeal metastases, or spinal cord compression
- Serious cardiovascular or cerebrovascular diseases
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 15 locations
1
University of California, San Diego
San Diego, California, United States, 92093
Actively Recruiting
2
Sarah Cannon Research Institute
Denver, Colorado, United States, 80218
Actively Recruiting
3
Advent Health
Orlando, Florida, United States, 32804
Actively Recruiting
4
Henry Ford Health Cancer
Detroit, Michigan, United States, 48202
Actively Recruiting
5
NYU Langone Health
New York, New York, United States, 10003
Actively Recruiting
6
The University of Texas - MD Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
7
NEXT Oncology, Virginia
Fairfax, Virginia, United States, 22031
Actively Recruiting
8
Swedish Cancer Institute
Seattle, Washington, United States, 98195
Actively Recruiting
9
BC Cancer Vancouver Centre
Vancouver, British Columbia, Canada
Actively Recruiting
10
Princess Margaret Cancer Centre
Toronto, Ontario, Canada
Actively Recruiting
11
Beijing Chest Hospital
Beijing, Beijing Municipality, China, 101149
Not Yet Recruiting
12
Harbin Medical University Cancer Hospital
Harbin, Heilongjiang, China, 150010
Not Yet Recruiting
13
Henan Cancer Hospital
Zhengzhou, Henan, China, 450008
Not Yet Recruiting
14
Shandong Cancer Hospital
Jinan, Shandong, China, 250117
Not Yet Recruiting
15
Shanghai Chest Hospital
Shanghai, Shanghai Municipality, China, 200030
Not Yet Recruiting
Research Team
A
Avistone Clinical Study Information Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here