Actively Recruiting
A Study to Investigate ANS03 in Participants With Locally Advanced or Metastatic Solid Tumors
Led by Avistone Biotechnology Co., Ltd. · Updated on 2026-03-13
96
Participants Needed
5
Research Sites
212 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a first-in-human Phase I, multi-center, open-label study of ANS03 in patients with advanced solid tumors. The study evaluates the safety, tolerability, preliminary efficay, pharmacokinetics, anti-tumor activity of ANS03 as monotherapy.
CONDITIONS
Official Title
A Study to Investigate ANS03 in Participants With Locally Advanced or Metastatic Solid Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 to 2
- Life expectancy of at least 12 weeks
- Measurable disease according to RECIST version 1.1
- Adequate organ and bone marrow function as defined in the study protocol
- Documented ROS1 or NTRK genetic alteration
You will not qualify if you...
- Active infection including tuberculosis, hepatitis B virus (HBV), hepatitis C virus (HCV), or HIV
- Known active or untreated central nervous system (CNS) metastases
- Carcinomatous meningitis, meningeal metastases, or spinal cord compression
- Serious cardiovascular or cerebrovascular diseases
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 5 locations
1
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10022
Actively Recruiting
2
Research Site
Fuzhou, Fujian, China
Actively Recruiting
3
Research Site
Guangzhou, Guangdong, China
Actively Recruiting
4
Research Site
Shanghai, Shanghai Municipality, China
Actively Recruiting
5
Research Site
Chengdu, Sichuan, China
Actively Recruiting
Research Team
A
Avistone Clinical Study Information Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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