Actively Recruiting
PREDICT: A Prospective, Multicenter Real-World Study to Describe the Clinical Outcome and Quality of Life in Chinese CRSwNP Patients
Led by AstraZeneca · Updated on 2026-05-12
200
Participants Needed
16
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to describe postoperative outcomes, quality of life, disease control, and characteristics of Chinese patients with chronic rhinosinusitis with nasal polyps (CRSwNP) who have undergone surgery. It also evaluates the economic burden and post-operative treatment patterns in patients with recurrent CRSwNP. The study is prospective and conducted across multiple centers in China, enrolling around 200 patients diagnosed with CRSwNP and scheduled for surgical treatment. Participants will undergo standard-of-care endoscopic sinus surgery (ESS) performed according to routine clinical practice and local guidelines. This surgical procedure serves as the baseline event for prospective observation. Researchers will monitor clinical outcomes, including Sino-Nasal Outcome Test (SNOT)-22 scores, Nasal Polyp Scores, and CT findings, over a 52-week period following surgery. Treatment decisions remain under the discretion of treating physicians. During the study, participants will receive regular clinical assessments and follow-ups to track changes in symptoms, quality of life, medication use, and recurrence rates. Evaluations include questionnaires like SNOT-22, spirometry, CT scans, and various symptom scores at multiple time points up to one year. The study also observes systemic medication use and post-operative complications to provide a comprehensive view of patient outcomes and disease control after surgery.
CONDITIONS
Brief Title
A Study to Investigate the Clinical Outcome and Quality of Life in Chinese Post-operative CRSwNP Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants must be 16 years of age or older at the time of signing informed consent
- Documented diagnosis of chronic rhinosinusitis with nasal polyps (CRSwNP)
- Endoscopic nasal polypectomy performed during the screening period
- Voluntary participation with signed informed consent
- No history or current psychiatric disorders, with normal cognitive functions including understanding and expression
You will not qualify if you...
- Any significant disease or disorder that may place the patient at risk or affect study results or ability to participate
- Currently participating in an interventional clinical study
- Inability to independently complete questionnaires due to language barriers or mental status
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Screening and enrollment visit
Duration - Day of surgery and immediate recovery period
Participants undergo standard Endoscopic Sinus Surgery (ESS) as part of routine clinical care, followed by immediate post-operative assessments.
1 visit (in-person) for surgery and immediate post-operative care
Duration - Up to 52 weeks after surgery
Participants attend scheduled clinical assessments to monitor post-operative outcomes, quality of life, disease control, and treatment patterns over one year.
Multiple visits including assessments at pre-operative baseline, 24 weeks, and 52 weeks post-operatively
Trial Site Locations
Total: 16 locations
1
Research Site
Changchun, China, 130033
Actively Recruiting
2
Research Site
Chengdu, China, 610078
Actively Recruiting
3
Research Site
Guangzhou, China, 510062
Actively Recruiting
4
Research Site
Guangzhou, China, 514700
Not Yet Recruiting
5
Research Site
Guangzhou, China
Actively Recruiting
6
Research Site
Haikou, China, 570311
Not Yet Recruiting
7
Research Site
Nanchang, China
Actively Recruiting
8
Research Site
Nanjing, China
Not Yet Recruiting
9
Research Site
Nanning, China, 530021
Actively Recruiting
10
Research Site
Qingdao, China
Withdrawn
11
Research Site
Shanghai, China, 200031
Actively Recruiting
12
Research Site
Shenzhen, China
Not Yet Recruiting
13
Research Site
Ürümqi, China, 830054
Actively Recruiting
14
Research Site
Wuhan, China, 430000
Actively Recruiting
15
Research Site
Wuhan, China
Actively Recruiting
16
Research Site
Xiamen, China, 361003
Actively Recruiting
Research Team
A
AstraZeneca Clinical Study Information Center
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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