Actively Recruiting

Phase 2
Age: 18Years +
All Genders
NCT07276581

A Study to Investigate Efficacy and Safety of AZD1163 in Participants With Rheumatoid Arthritis

Led by AstraZeneca · Updated on 2026-05-05

320

Participants Needed

144

Research Sites

139 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Phase II study in participants with moderately-to-severely active rheumatoid Arthritis (RA) to evaluate efficacy and safety of AZD1163.

CONDITIONS

Official Title

A Study to Investigate Efficacy and Safety of AZD1163 in Participants With Rheumatoid Arthritis

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Diagnosed with adult-onset rheumatoid arthritis as defined by the 2010 ACR/EULAR criteria for at least 12 weeks before screening
  • Moderately-to-severely active rheumatoid arthritis with at least 6 swollen joints and 6 tender joints and elevated CRP
  • Positive anti-citrullinated peptide antibody (ACPA) test at screening
  • History of inadequate response, loss of response, or intolerance to at least one csDMARD and/or one to two TNFi treatments
  • At least 12 weeks of treatment and 4 weeks of stable dosing on csDMARD and/or subcutaneous TNFi before randomisation
Not Eligible

You will not qualify if you...

  • History or evidence of other autoimmune or conditions that could confuse the diagnosis of rheumatoid arthritis, except secondary Sjogren's disease
  • Have received or plan to receive any biologic DMARDs other than TNFi or targeted synthetic DMARDs

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 144 locations

1

Research Site

Glendale, Arizona, United States, 85306

Not Yet Recruiting

2

Research Site

Prescott Valley, Arizona, United States, 86314

Withdrawn

3

Research Site

Tucson, Arizona, United States, 85748

Not Yet Recruiting

4

Research Site

La Jolla, California, United States, 92037

Not Yet Recruiting

5

Research Site

San Dimas, California, United States, 91773

Withdrawn

6

Research Site

San Leandro, California, United States, 94578

Not Yet Recruiting

7

Research Site

Aurora, Colorado, United States, 80045

Not Yet Recruiting

8

Research Site

Boynton Beach, Florida, United States, 33435

Withdrawn

9

Research Site

Jacksonville, Florida, United States, 32216

Withdrawn

10

Research Site

South Miami, Florida, United States, 33143

Actively Recruiting

11

Research Site

Tampa, Florida, United States, 33607

Withdrawn

12

Research Site

Winter Haven, Florida, United States, 33880

Not Yet Recruiting

13

Research Site

Marietta, Georgia, United States, 30060

Not Yet Recruiting

14

Research Site

Skokie, Illinois, United States, 60076

Not Yet Recruiting

15

Research Site

Willowbrook, Illinois, United States, 60527

Actively Recruiting

16

Research Site

Lake Charles, Louisiana, United States, 70605

Not Yet Recruiting

17

Research Site

Baltimore, Maryland, United States, 21224

Not Yet Recruiting

18

Research Site

New Bedford, Massachusetts, United States, 02740

Actively Recruiting

19

Research Site

Kansas City, Missouri, United States, 64151

Not Yet Recruiting

20

Research Site

St Louis, Missouri, United States, 63131

Not Yet Recruiting

21

Research Site

Henderson, Nevada, United States, 89052

Actively Recruiting

22

Research Site

Myrtle Beach, South Carolina, United States, 29572

Not Yet Recruiting

23

Research Site

Austin, Texas, United States, 78745

Actively Recruiting

24

Research Site

Baytown, Texas, United States, 77521

Actively Recruiting

25

Research Site

Houston, Texas, United States, 77027

Not Yet Recruiting

26

Research Site

Houston, Texas, United States, 77089

Actively Recruiting

27

Research Site

Mesquite, Texas, United States, 75150

Not Yet Recruiting

28

Research Site

Tomball, Texas, United States, 77375

Actively Recruiting

29

Research Site

Caba, Argentina, C1128AAF

Not Yet Recruiting

30

Research Site

Ciudad de Buenos Aires, Argentina, C1015ABO

Not Yet Recruiting

31

Research Site

Ciudad de Buenos Aires, Argentina, C1428DUQ

Not Yet Recruiting

32

Research Site

Córdoba, Argentina, X5000EDC

Not Yet Recruiting

33

Research Site

San Isidro, Argentina, 1643

Not Yet Recruiting

34

Research Site

San Miguel de Tucumán, Argentina, T4000AXL

Not Yet Recruiting

35

Research Site

Juiz de Fora, Brazil, 36010 570

Not Yet Recruiting

36

Research Site

Pelotas, Brazil, 96040-010

Not Yet Recruiting

37

Research Site

Porto Alegre, Brazil, 90035-903

Not Yet Recruiting

38

Research Site

Porto Alegre, Brazil, 9061-000

Not Yet Recruiting

39

Research Site

Salvador, Brazil, 41820-020

Not Yet Recruiting

40

Research Site

São Paulo, Brazil, 04266-010

Withdrawn

41

Research Site

São Paulo, Brazil, 05403-9000

Not Yet Recruiting

42

Research Site

Haskovo, Bulgaria, 6304

Not Yet Recruiting

43

Research Site

Pleven, Bulgaria, 5800

Not Yet Recruiting

44

Research Site

Sofia, Bulgaria, 1113

Not Yet Recruiting

45

Research Site

Sofia, Bulgaria, 1336

Not Yet Recruiting

46

Research Site

Sofia, Bulgaria, 1606

Not Yet Recruiting

47

Research Site

Sofia, Bulgaria, 1612

Not Yet Recruiting

48

Research Site

Windsor, Ontario, Canada, N8X 5A7

Actively Recruiting

49

Research Site

Trois-Rivières, Quebec, Canada, G9A 3Y2

Actively Recruiting

50

Research Site

Providencia, Chile, 7510186

Not Yet Recruiting

51

Research Site

Santiago, Chile, 7500571

Not Yet Recruiting

52

Research Site

Santiago, Chile, 7500587

Not Yet Recruiting

53

Research Site

Temuco, Chile, 4810345

Not Yet Recruiting

54

Research Site

Valdivia, Chile, 5110683

Not Yet Recruiting

55

Research Site

Victoria, Chile, 4720097

Not Yet Recruiting

56

Research Site

Viña del Mar, Chile, 2531172

Not Yet Recruiting

57

Research Site

Beijing, China, 100144

Not Yet Recruiting

58

Research Site

Beijing, China, 100730

Not Yet Recruiting

59

Research Site

Changchun, China, 130021

Not Yet Recruiting

60

Research Site

Changsha, China, 410008

Not Yet Recruiting

61

Research Site

Guangzhou, China, 510515

Not Yet Recruiting

62

Research Site

Jiujiang, China, 332000

Not Yet Recruiting

63

Research Site

Kunming, China, 650032

Not Yet Recruiting

64

Research Site

Linyi, China, CN-276003

Not Yet Recruiting

65

Research Site

Nanchong, China, 637000

Not Yet Recruiting

66

Research Site

Panjin, China, 124000

Not Yet Recruiting

67

Research Site

Pingxiang, China, 337055

Not Yet Recruiting

68

Research Site

Shantou, China, 515041

Not Yet Recruiting

69

Research Site

Xuzhou, China, 221009

Not Yet Recruiting

70

Research Site

Yangzhou, China, 225001

Not Yet Recruiting

71

Research Site

Zhengzhou, China, 450000

Not Yet Recruiting

72

Research Site

Bad Doberan, Germany, 18209

Not Yet Recruiting

73

Research Site

Berlin, Germany, 12161

Not Yet Recruiting

74

Research Site

Hamburg, Germany, 20095

Not Yet Recruiting

75

Research Site

Sendenhorst, Germany, 48324

Not Yet Recruiting

76

Research Site

Budapest, Hungary, 1023

Not Yet Recruiting

77

Research Site

Budapest, Hungary, 1027

Not Yet Recruiting

78

Research Site

Budapest, Hungary, 1036

Not Yet Recruiting

79

Research Site

Debrecen, Hungary, 4032

Not Yet Recruiting

80

Research Site

Gyula, Hungary, 5700

Not Yet Recruiting

81

Research Site

Szeged, Hungary, 6725

Not Yet Recruiting

82

Research Site

Székesfehérvár, Hungary, 8000

Not Yet Recruiting

83

Research Site

Veszprém, Hungary, 8200

Not Yet Recruiting

84

Research Site

Aomori, Japan, 030-8553

Not Yet Recruiting

85

Research Site

Bunkyō City, Japan, 113-8655

Not Yet Recruiting

86

Research Site

Fukuoka, Japan, 815-8555

Not Yet Recruiting

87

Research Site

Hamamatsu, Japan, 430-0906

Not Yet Recruiting

88

Research Site

Hitachi-Naka, Japan, 312-0057

Not Yet Recruiting

89

Research Site

Iizuka-shi, Japan, 820-8505

Not Yet Recruiting

90

Research Site

Kawachinagano-shi, Japan, 586-8521

Not Yet Recruiting

91

Research Site

Matsuyama, Japan, 790-8524

Not Yet Recruiting

92

Research Site

Meguro-ku, Japan, 152-8902

Not Yet Recruiting

93

Research Site

Miyazaki, Japan, 880-0834

Not Yet Recruiting

94

Research Site

Nagoya, Japan, 457-8511

Not Yet Recruiting

95

Research Site

Okayama, Japan, 700-8557

Withdrawn

96

Research Site

Sagamihara-shi, Japan, 252-0315

Not Yet Recruiting

97

Research Site

Sapporo, Japan, 060-0001

Withdrawn

98

Research Site

Sasebo-shi, Japan, 857-1195

Actively Recruiting

99

Research Site

Sayama-shi, Japan, 350-1305

Not Yet Recruiting

100

Research Site

Yokohama, Japan, 236-0037

Not Yet Recruiting

101

Research Site

Chihuahua City, Mexico, 31000

Not Yet Recruiting

102

Research Site

Estado de México, Mexico, 50090

Not Yet Recruiting

103

Research Site

Guadalajara, Mexico, 44160

Not Yet Recruiting

104

Research Site

Guadalajara, Mexico, 44650

Not Yet Recruiting

105

Research Site

Guadalajara, Mexico, 44690

Not Yet Recruiting

106

Research Site

Gustavo A. Madero, Mexico, 07300

Not Yet Recruiting

107

Research Site

Mexicali, Mexico, 021100

Not Yet Recruiting

108

Research Site

Mexico City, Mexico, 06700

Not Yet Recruiting

109

Research Site

Mérida, Mexico, 97070

Not Yet Recruiting

110

Research Site

Monterrey, Mexico, 64460

Not Yet Recruiting

111

Research Site

San Luis Potosí City, Mexico, 78213

Withdrawn

112

Research Site

Krakow, Poland, 30-002

Not Yet Recruiting

113

Research Site

Krakow, Poland, 30-727

Not Yet Recruiting

114

Research Site

Torun, Poland, 87-100

Not Yet Recruiting

115

Research Site

Warsaw, Poland, 00-874

Not Yet Recruiting

116

Research Site

Wroclaw, Poland, 50-244

Not Yet Recruiting

117

Research Site

Caguas, Puerto Rico, 00725

Not Yet Recruiting

118

Research Site

Brackenfell, South Africa, 7560

Not Yet Recruiting

119

Research Site

Cape Town, South Africa, 7500

Not Yet Recruiting

120

Research Site

Durban, South Africa, 4319

Not Yet Recruiting

121

Research Site

Pinelands, South Africa, 7405

Not Yet Recruiting

122

Research Site

Pretoria, South Africa, 0002

Not Yet Recruiting

123

Research Site

Pretoria, South Africa

Not Yet Recruiting

124

Research Site

Somerset West, South Africa, 7130

Not Yet Recruiting

125

Research Site

Barcelona, Spain, 08003

Not Yet Recruiting

126

Research Site

Barcelona, Spain, 08035

Not Yet Recruiting

127

Research Site

Barcelona, Spain, 08041

Not Yet Recruiting

128

Research Site

Málaga, Spain, 29009

Not Yet Recruiting

129

Research Site

Sabadell, Spain, 08208

Not Yet Recruiting

130

Research Site

Santiago de Compostela, Spain, 15706

Not Yet Recruiting

131

Research Site

Valencia, Spain, 46026

Not Yet Recruiting

132

Research Site

Ivano-Frankivsk, Ukraine, 76018

Actively Recruiting

133

Research Site

Kyiv, Ukraine, 02002

Actively Recruiting

134

Research Site

Kyiv, Ukraine, 03037

Actively Recruiting

135

Research Site

Kyiv, Ukraine, 03049

Actively Recruiting

136

Research Site

Kyiv, Ukraine, 04050

Actively Recruiting

137

Research Site

Kyiv, Ukraine, 04210

Actively Recruiting

138

Research Site

Uzhhorod, Ukraine, 88000

Actively Recruiting

139

Research Site

Vinnytsia, Ukraine, 21018

Actively Recruiting

140

Research Site

Vinnytsia, Ukraine, 21029

Actively Recruiting

141

Research Site

Glasgow, United Kingdom, G31 2ER

Actively Recruiting

142

Research Site

Leeds, United Kingdom, LS7 4SA

Actively Recruiting

143

Research Site

Luton, United Kingdom, LU4 0DZ

Not Yet Recruiting

144

Research Site

Staffordshire, United Kingdom, WS11 5XY

Not Yet Recruiting

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Research Team

A

AstraZeneca Clinical Study Information Center

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

QUADRUPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

4

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A Study to Investigate Efficacy and Safety of AZD1163 in Participants With Rheumatoid Arthritis | DecenTrialz