Actively Recruiting
A Study to Investigate Efficacy and Safety of SAR442970 in Patients With Crohn's Disease
Led by Sanofi · Updated on 2026-03-27
99
Participants Needed
66
Research Sites
228 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a phase 2b, randomized, double-blind, 3-arm study for the treatment of Crohn's disease. The primary objective of this study is to assess the efficacy of different doses of SAR442970 compared with placebo in participants with moderate to severe Crohn's disease. The total study duration is up to 168 weeks, with a treatment period of up to 158 weeks including an open-label (OL) long-term extension (LTE) period of up to 104 weeks for eligible participants.
CONDITIONS
Official Title
A Study to Investigate Efficacy and Safety of SAR442970 in Patients With Crohn's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of Crohn's Disease for at least 3 months prior to screening
- Confirmed moderate-to-severe Crohn's Disease
- History of prior exposure to standard treatments or advanced therapies with inadequate response, loss of response, or intolerance to at least one
- On stable doses of standard treatments prior to screening
- Contraceptive use consistent with local regulations for clinical study participants
You will not qualify if you...
- Active Ulcerative Colitis, indeterminate colitis, adenomatous colonic polyps not removed, colonic mucosal dysplasia, or short bowel syndrome
- Crohn's Disease isolated to stomach, duodenum, jejunum, or perianal region without colonic or ileal involvement
- Ongoing complications requiring bowel surgery during study
- Presence of ostomy or ileoanal pouch
- Conditions interfering with drug absorption, including short bowel syndrome
- Surgical bowel resection within 3 months before screening or history of more than 3 bowel resections
- Any other condition that may pose risk according to the Investigator's opinion
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 66 locations
1
Investigational Site Number: 8400024
Tucson, Arizona, United States, 85724
Actively Recruiting
2
Investigational Site Number: 8400005
Escondido, California, United States, 92025
Actively Recruiting
3
Investigational Site Number: 8400001
Lancaster, California, United States, 93534
Actively Recruiting
4
Investigational Site Number: 8400017
Kissimmee, Florida, United States, 34741
Actively Recruiting
5
Investigational Site Number: 8400015
Lighthouse PT, Florida, United States, 33064
Actively Recruiting
6
Investigational Site Number 8400028
Miami, Florida, United States, 33134
Actively Recruiting
7
Investigational Site Number: 8400012
Miami, Florida, United States, 33136
Actively Recruiting
8
Investigational Site Number: 8400007
Orlando, Florida, United States, 32804
Actively Recruiting
9
Investigational Site Number: 8400011
Palmetto Bay, Florida, United States, 33176
Actively Recruiting
10
Investigational Site Number: 8400019
Marietta, Georgia, United States, 30060
Actively Recruiting
11
Investigational Site Number: 8400025
Iowa City, Iowa, United States, 52242
Actively Recruiting
12
Investigational Site Number: 8400006
Kansas City, Kansas, United States, 66160
Actively Recruiting
13
Investigational Site Number: 8400022
Boston, Massachusetts, United States, 02115
Actively Recruiting
14
Investigational Site Number: 8400008
Wyoming, Michigan, United States, 49519
Actively Recruiting
15
Investigational Site Number: 8400013
St Louis, Missouri, United States, 63110
Actively Recruiting
16
Investigational Site Number: 8400003
Chapel Hill, North Carolina, United States, 27599
Actively Recruiting
17
Investigational Site Number: 8400009
Harrisburg, Pennsylvania, United States, 17110
Actively Recruiting
18
Investigational Site Number: 8400002
Fredericksburg, Texas, United States, 78229
Actively Recruiting
19
Investigational Site Number: 8400016
Ogden, Utah, United States, 84405
Actively Recruiting
20
Investigational Site Number: 8400027
Richmond, Virginia, United States, 23249
Actively Recruiting
21
Investigational Site Number: 0360002
Brisbane, Queensland, Australia, 4101
Actively Recruiting
22
Investigational Site Number: 0360004
Kurralta Park, South Australia, Australia, 5037
Actively Recruiting
23
Investigational Site Number: 0360001
Footscray, Australia, 3011
Actively Recruiting
24
Investigational Site Number: 0560001
Leuven, Belgium, B-3000
Actively Recruiting
25
Investigative Site: 1560003
Changsha, China, 410011
Actively Recruiting
26
Investigational Site Number: 1560008
Changsha, China, 410013
Actively Recruiting
27
Investigative Site: 1560005
Changzhou, China, 213003
Actively Recruiting
28
Investigational Site Number: 1560001
Guangzhou, China, 510655
Actively Recruiting
29
Investigational Site Number: 1560006
Hangzhou, China, 310009
Actively Recruiting
30
Investigative Site: 1560004
Nanchang, China, 330006
Actively Recruiting
31
Investigative Site: 1560002
Shanghai, China, 200092
Actively Recruiting
32
Investigational Site Number: 1560007
Shenyang, China, 110004
Actively Recruiting
33
Investigational Site Number: 2030002
Brno, JM, Czechia, 61500
Actively Recruiting
34
Investigational Site Number: 2030003
Hradec Králové, Czechia, 50012
Actively Recruiting
35
Investigational Site Number: 2030005
Slaný, Czechia, 274 01
Actively Recruiting
36
Investigational Site Number: 2500001
Montpellier, France, 34090
Actively Recruiting
37
Investigational Site Number: 2500003
Nice, France, 6000
Actively Recruiting
38
Investigational Site Number: 2500002
Toulouse, France, 31059
Actively Recruiting
39
Investigational Site Number: 2760002
Minden, Northwest, Germany, 32423
Actively Recruiting
40
Investigational Site Number: 2760003
Jena, Germany, 07747
Actively Recruiting
41
Investigational Site Number: 2760004
Kiel, Germany, 24105
Actively Recruiting
42
Investigational Site Number: 2760001
Ulm, Germany, 89081
Actively Recruiting
43
Investigational Site Number: 3920007
Kashiwa, Chiba, Japan, 277-0871
Actively Recruiting
44
Investigational Site Number: 3920005
Ōita, Oita Prefecture, Japan, 870-0033
Actively Recruiting
45
Investigational Site Number: 3920006
Hamamatsu, Shizuoka, Japan, 432-8061
Actively Recruiting
46
Investigational Site Number: 3920004
Bunkyō City, Japan, 113-8519
Actively Recruiting
47
Investigational Site Number: 3920003
Hamamatsu, Japan, 431-3192
Actively Recruiting
48
Investigational Site Number: 3920009
Hirosaki, Japan, 036-8545
Actively Recruiting
49
Investigational Site Number: 3920001
Morioka, Japan, 020-8505
Actively Recruiting
50
Investigational Site Number: 3920002
Nishinomiya, Japan, 663-8501
Actively Recruiting
51
Investigational Site Number: 6160002
Wroclaw, Lower Silesian Voivodeship, Poland, 53-149
Actively Recruiting
52
Investigational Site Number: 6160001
Krakow, Poland, 31-501
Actively Recruiting
53
Investigational Site Number: 6160005
Lublin, Poland, 20-582
Actively Recruiting
54
Investigational Site Number: 6160006
Sopot, Poland, 81-756
Actively Recruiting
55
Investigational Site Number: 6160008
Warsaw, Poland, 00-189
Actively Recruiting
56
Investigational Site Number: 6160003
Warsaw, Poland, 01-783
Actively Recruiting
57
Investigational Site Number: 6160004
Wroclaw, Poland, 54-206
Actively Recruiting
58
Investigational Site Number: 7100003
Johannesburg, South Africa, 1619
Actively Recruiting
59
Investigational Site Number: 7240002
Madrid, Spain, 28003
Actively Recruiting
60
Investigational Site Number: 7240001
Madrid, Spain, 28046
Actively Recruiting
61
Investigational Site Number: 7240003
Seville, Spain, 41009
Actively Recruiting
62
Investigational Site Number: 8260007
Bury, United Kingdom, BL9 7TD
Actively Recruiting
63
Investigational Site Number: 8260004
Cambridge, United Kingdom, CB2 0QQ
Actively Recruiting
64
Investigational Site Number: 8260005
London, United Kingdom, E11 1NR
Actively Recruiting
65
Investigational Site Number: 8260002
London, United Kingdom, HA8 0AD
Actively Recruiting
66
Investigational Site Number: 8260001
London, United Kingdom, SE1 7EH
Actively Recruiting
Research Team
T
Trial Transparency email recommended (Toll free for US & Canada)
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here