Actively Recruiting
A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00007)
Led by AstraZeneca · Updated on 2026-05-07
990
Participants Needed
268
Research Sites
219 weeks
Total Duration
On this page
Sponsors
A
AstraZeneca
Lead Sponsor
A
Amgen
Collaborating Sponsor
AI-Summary
What this Trial Is About
A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel Group, Phase 3 Study to Evaluate the Efficacy and Safety of Tezepelumab in Adults with Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD)
CONDITIONS
Official Title
A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00007)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 40 and 80 years
- Diagnosed with COPD for at least 1 year
- Post-bronchodilator FEV1 between 20% and 70% predicted normal, and FEV1/FVC ratio less than 0.70 at screening
- On triple (ICS+LABA+LAMA) or dual inhaled COPD therapy for at least 3 consecutive months before Visit 1
- Experienced at least 2 moderate or 1 severe COPD exacerbations in the prior year; at least one moderate exacerbation required systemic corticosteroids
- Eosinophil count of 150 cells/µL or higher during screening
- COPD Assessment Test (CAT) score of 15 or higher at screening
- Former or current smokers with at least 10 pack-years smoking history
You will not qualify if you...
- Presence of any clinically important lung disease or radiological signs of respiratory disease other than COPD
- Diagnosis of asthma, including pediatric asthma, or asthma-COPD overlap syndrome (ACOS)
- Any unstable medical condition that could affect safety or study results
- Tuberculosis requiring treatment within 12 months before Visit 2
- Current or past malignancies
- Use of macrolide antibiotics within the past 6 months
- Use of systemic immunosuppressive or immunomodulating medications
- Long-term oxygen therapy exceeding 4.0 L/min or oxygen saturation below 89% despite oxygen therapy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 268 locations
1
Research Site
Cullman, Alabama, United States, 35055
Actively Recruiting
2
Research Site
Phoenix, Arizona, United States, 85044
Actively Recruiting
3
Research Site
Scottsdale, Arizona, United States, 85258
Actively Recruiting
4
Research Site
Inglewood, California, United States, 90301
Withdrawn
5
Research Site
Los Angeles, California, United States, 90048
Actively Recruiting
6
Research Site
Palo Alto, California, United States, 94304
Actively Recruiting
7
Research Site
Redding, California, United States, 96001
Actively Recruiting
8
Research Site
San Diego, California, United States, 92108
Actively Recruiting
9
Research Site
New Britain, Connecticut, United States, 06051
Actively Recruiting
10
Research Site
Wilmington, Delaware, United States, 19803
Actively Recruiting
11
Research Site
Bay Pines, Florida, United States, 33744
Actively Recruiting
12
Research Site
Boynton Beach, Florida, United States, 33435
Actively Recruiting
13
Research Site
Clearwater, Florida, United States, 33765
Actively Recruiting
14
Research Site
Fleming Island, Florida, United States, 32003
Actively Recruiting
15
Research Site
Jacksonville, Florida, United States, 32209
Actively Recruiting
16
Research Site
Leesburg, Florida, United States, 34748
Actively Recruiting
17
Research Site
Margate, Florida, United States, 33063
Withdrawn
18
Research Site
Miami, Florida, United States, 33126
Actively Recruiting
19
Research Site
Miami, Florida, United States, 33155
Actively Recruiting
20
Research Site
Miami Lakes, Florida, United States, 33014
Suspended
21
Research Site
Ocala, Florida, United States, 34470
Actively Recruiting
22
Research Site
Palmetto Bay, Florida, United States, 33157
Actively Recruiting
23
Research Site
Winter Park, Florida, United States, 32789
Actively Recruiting
24
Research Site
Adairsville, Georgia, United States, 30103
Actively Recruiting
25
Research Site
Atlanta, Georgia, United States, 30349
Actively Recruiting
26
Research Site
Cordele, Georgia, United States, 31015
Actively Recruiting
27
Research Site
Decatur, Georgia, United States, 30033
Not Yet Recruiting
28
Research Site
Fort Eisenhower, Georgia, United States, 30905
Withdrawn
29
Research Site
Savannah, Georgia, United States, 31406
Actively Recruiting
30
Research Site
Evanston, Illinois, United States, 60201
Not Yet Recruiting
31
Research Site
Evansville, Indiana, United States, 47725
Actively Recruiting
32
Research Site
Indianapolis, Indiana, United States, 46202
Actively Recruiting
33
Research Site
Indianapolis, Indiana, United States, 46268
Actively Recruiting
34
Research Site
Kansas City, Kansas, United States, 66160
Actively Recruiting
35
Research Site
Bowling Green, Kentucky, United States, 42101
Actively Recruiting
36
Research Site
Owensboro, Kentucky, United States, 42301
Actively Recruiting
37
Research Site
Baltimore, Maryland, United States, 21224
Actively Recruiting
38
Research Site
Potomac, Maryland, United States, 20854
Actively Recruiting
39
Research Site
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
40
Research Site
Minneapolis, Minnesota, United States, 55425
Actively Recruiting
41
Research Site
Hannibal, Missouri, United States, 63401
Actively Recruiting
42
Research Site
Staten Island, New York, United States, 10309
Not Yet Recruiting
43
Research Site
Syracuse, New York, United States, 13203
Not Yet Recruiting
44
Research Site
Charlotte, North Carolina, United States, 28277
Actively Recruiting
45
Research Site
Fayetteville, North Carolina, United States, 28303
Withdrawn
46
Research Site
Oklahoma City, Oklahoma, United States, 73102
Actively Recruiting
47
Research Site
Tulsa, Oklahoma, United States, 74133
Actively Recruiting
48
Research Site
Grants Pass, Oregon, United States, 97527
Withdrawn
49
Research Site
Sayre, Pennsylvania, United States, 18840
Not Yet Recruiting
50
Research Site
Anderson, South Carolina, United States, 29621
Actively Recruiting
51
Research Site
Columbia, South Carolina, United States, 29204
Actively Recruiting
52
Research Site
Gaffney, South Carolina, United States, 29340
Actively Recruiting
53
Research Site
Spartanburg, South Carolina, United States, 29303
Actively Recruiting
54
Research Site
Union, South Carolina, United States, 29379
Actively Recruiting
55
Research Site
Rapid City, South Dakota, United States, 57702
Actively Recruiting
56
Research Site
Knoxville, Tennessee, United States, 37919
Actively Recruiting
57
Research Site
Boerne, Texas, United States, 78006
Actively Recruiting
58
Research Site
El Paso, Texas, United States, 79902
Actively Recruiting
59
Research Site
Houston, Texas, United States, 77008
Actively Recruiting
60
Research Site
Houston, Texas, United States, 77074
Actively Recruiting
61
Research Site
Houston, Texas, United States, 77094
Not Yet Recruiting
62
Research Site
Lewisville, Texas, United States, 75067
Actively Recruiting
63
Research Site
McKinney, Texas, United States, 75069
Actively Recruiting
64
Research Site
Mesquite, Texas, United States, 75149
Actively Recruiting
65
Research Site
San Antonio, Texas, United States, 78258
Not Yet Recruiting
66
Research Site
Colchester, Vermont, United States, 05446
Actively Recruiting
67
Research Site
Williamsburg, Virginia, United States, 23188
Actively Recruiting
68
Research Site
Everett, Washington, United States, 98208
Actively Recruiting
69
Research Site
Alberdi, Argentina, X5033DCE
Actively Recruiting
70
Research Site
Buenos Aires, Argentina, C1425BEN
Actively Recruiting
71
Research Site
Ciudad de Buenos Aires, Argentina, C1414AIF
Actively Recruiting
72
Research Site
Florida, Argentina, B1602DQD
Actively Recruiting
73
Research Site
La Plata, Argentina, B1900
Actively Recruiting
74
Research Site
La Plata, Argentina, B1904
Actively Recruiting
75
Research Site
Mar del Plata, Argentina, 7600
Actively Recruiting
76
Research Site
Mendoza, Argentina, M5500CCG
Actively Recruiting
77
Research Site
Quilmes, Argentina, B1878FNR
Actively Recruiting
78
Research Site
Rosario, Argentina, 2000
Actively Recruiting
79
Research Site
San Fernando, Argentina, B1646EBJ
Actively Recruiting
80
Research Site
San Juan Bautista, Argentina, 1888
Actively Recruiting
81
Research Site
Coffs Harbour, Australia, 02450
Actively Recruiting
82
Research Site
Frankston, Australia, 3199
Actively Recruiting
83
Research Site
Garran, Australia, 2605
Withdrawn
84
Research Site
Nedlands, Australia, 6009
Actively Recruiting
85
Research Site
New Lambton, Australia, 2310
Actively Recruiting
86
Research Site
Spearwood, Australia, 6163
Actively Recruiting
87
Research Site
Wollongong, Australia, 2500
Withdrawn
88
Research Site
Woodville South, Australia, 5011
Actively Recruiting
89
Research Site
Genk, Belgium, 3600
Actively Recruiting
90
Research Site
Ghent, Belgium, 9000
Actively Recruiting
91
Research Site
Jette, Belgium, 1090
Actively Recruiting
92
Research Site
Leuven, Belgium, 3000
Actively Recruiting
93
Research Site
Mechelen, Belgium, 2800
Actively Recruiting
94
Research Site
Namur, Belgium, 5101
Actively Recruiting
95
Research Site
Dupnitsa, Bulgaria, 2600
Actively Recruiting
96
Research Site
Haskovo, Bulgaria, 6300
Actively Recruiting
97
Research Site
Lovech, Bulgaria, 5500
Withdrawn
98
Research Site
Pleven, Bulgaria, 5800
Actively Recruiting
99
Research Site
Plovdiv, Bulgaria, 4003
Actively Recruiting
100
Research Site
Rousse, Bulgaria, 7000
Withdrawn
101
Research Site
Rousse, Bulgaria, 7000
Actively Recruiting
102
Research Site
Sofia, Bulgaria, 1000
Actively Recruiting
103
Research Site
Sofia, Bulgaria, 1202
Withdrawn
104
Research Site
Sofia, Bulgaria, 1431
Actively Recruiting
105
Research Site
Sofia, Bulgaria, 1756
Actively Recruiting
106
Research Site
Stara Zagora, Bulgaria, 6003
Actively Recruiting
107
Research Site
Varna, Bulgaria, 9000
Withdrawn
108
Research Site
Veliko Tanovo, Bulgaria, 5000
Actively Recruiting
109
Research Site
Veliko Tarnovo, Bulgaria, 5000
Actively Recruiting
110
Research Site
Vidin, Bulgaria, 3700
Actively Recruiting
111
Research Site
Yambol, Bulgaria, 8600
Actively Recruiting
112
Research Site
Armenia, Colombia, 630004
Not Yet Recruiting
113
Research Site
Barranquilla, Colombia, 080020
Actively Recruiting
114
Research Site
Bogotá, Colombia, 110131
Actively Recruiting
115
Research Site
Cali, Colombia, 760042
Actively Recruiting
116
Research Site
Ibague, Colombia, 730006
Actively Recruiting
117
Research Site
Manizales, Colombia, 170004
Actively Recruiting
118
Research Site
Medellín, Colombia, 050022
Actively Recruiting
119
Research Site
Medellín, Colombia, 050030
Actively Recruiting
120
Research Site
Aalborg, Denmark, 9000
Actively Recruiting
121
Research Site
Hvidovre, Denmark, 2650
Actively Recruiting
122
Research Site
Næstved, Denmark, 4700
Actively Recruiting
123
Research Site
Odense C, Denmark, 5000
Actively Recruiting
124
Research Site
Vejle, Denmark, 7100
Actively Recruiting
125
Research Site
Brest, France, 29609
Actively Recruiting
126
Research Site
Lyon, France, 69317
Actively Recruiting
127
Research Site
Marseille, France, 13915
Actively Recruiting
128
Research Site
Montpellier, France, 34295
Actively Recruiting
129
Research Site
Paris, France, 75014
Actively Recruiting
130
Research Site
Paris, France, 75877
Actively Recruiting
131
Research Site
Pessac, France, 33604
Actively Recruiting
132
Research Site
Saint-Herblain, France, 44800
Actively Recruiting
133
Research Site
Athens, Greece, 11521
Actively Recruiting
134
Research Site
Athens, Greece, 11527
Actively Recruiting
135
Research Site
Athens, Greece, 17562
Actively Recruiting
136
Research Site
Heraklion, Greece, 71110
Actively Recruiting
137
Research Site
Ioannina, Greece, 45500
Actively Recruiting
138
Research Site
Pátrai, Greece, 26332
Actively Recruiting
139
Research Site
Thessaloniki, Greece, 57001
Actively Recruiting
140
Research Site
Thessaloniki, Greece, 57010
Actively Recruiting
141
Research Site
Hong Kong, Hong Kong, 999077
Actively Recruiting
142
Research Site
Hong Kong, Hong Kong
Actively Recruiting
143
Research Site
Budapest, Hungary, 1036
Actively Recruiting
144
Research Site
Debrecen, Hungary, 4032
Actively Recruiting
145
Research Site
Edelény, Hungary, 3780
Actively Recruiting
146
Research Site
Gödöllő, Hungary, 2100
Actively Recruiting
147
Research Site
Hatvan, Hungary, 3000
Actively Recruiting
148
Research Site
Mosonmagyaróvár, Hungary, 9200
Actively Recruiting
149
Research Site
Nyíregyháza-Sóstóhegy, Hungary, 4481
Actively Recruiting
150
Research Site
Törökbálint, Hungary, 2045
Actively Recruiting
151
Research Site
Ashkelon, Israel, 78278
Actively Recruiting
152
Research Site
Haifa, Israel, 34362
Actively Recruiting
153
Research Site
Jerusalem, Israel, 00000
Actively Recruiting
154
Research Site
Jerusalem, Israel, 90131
Actively Recruiting
155
Research Site
Kfar Saba, Israel, 4428164
Actively Recruiting
156
Research Site
Ramat Gan, Israel, 52621
Actively Recruiting
157
Research Site
Rehovot, Israel, 76100
Actively Recruiting
158
Research Site
Tel Aviv, Israel, 6423906
Actively Recruiting
159
Research Site
Akashi-shi, Japan, 674-0063
Actively Recruiting
160
Research Site
Chikushino-shi, Japan, 818-8502
Actively Recruiting
161
Research Site
Chiyoda-ku, Japan, 1020074
Actively Recruiting
162
Research Site
Fukui-shi, Japan, 910-8526
Actively Recruiting
163
Research Site
Fukuoka, Japan, 811-1394
Actively Recruiting
164
Research Site
Fukuoka, Japan, 819-8555
Actively Recruiting
165
Research Site
Gifu, Japan, 502-8558
Actively Recruiting
166
Research Site
Iruma-Gun, Japan, 350-0495
Actively Recruiting
167
Research Site
Ishinomaki, Japan, 986-8522
Actively Recruiting
168
Research Site
Kasuga-shi, Japan, 816-0864
Actively Recruiting
169
Research Site
Kitakyushu-shi, Japan, 807-8555
Actively Recruiting
170
Research Site
Kiyose-shi, Japan, 204-8522
Actively Recruiting
171
Research Site
Kiyose-shi, Japan, 204-8585
Actively Recruiting
172
Research Site
Kobe, Japan, 650-0047
Actively Recruiting
173
Research Site
Komatsu-shi, Japan, 923-8560
Actively Recruiting
174
Research Site
Kure-shi, Japan, 737-8505
Actively Recruiting
175
Research Site
Kyoto, Japan, 612-8555
Actively Recruiting
176
Research Site
Matsusaka-shi, Japan, 515-8544
Actively Recruiting
177
Research Site
Meguro-ku, Japan, 153-0051
Withdrawn
178
Research Site
Minatoku, Japan, 105-8470
Actively Recruiting
179
Research Site
Minatoku, Japan, 108-0073
Actively Recruiting
180
Research Site
Miyazaki, Japan, 889-1692
Actively Recruiting
181
Research Site
Mizunami-shi, Japan, 509-6134
Actively Recruiting
182
Research Site
Nagaoka-shi, Japan, 940-8621
Actively Recruiting
183
Research Site
Nagasaki, Japan, 852-8501
Actively Recruiting
184
Research Site
Nagoya, Japan, 457-0866
Actively Recruiting
185
Research Site
Nagoya, Japan, 457-8511
Actively Recruiting
186
Research Site
Nagoya, Japan, 466-8650
Actively Recruiting
187
Research Site
Nerima-ku, Japan, 177-8521
Actively Recruiting
188
Research Site
Ohta-ku, Japan, 143-0013
Withdrawn
189
Research Site
Okayama, Japan, 700-8558
Actively Recruiting
190
Research Site
Okayama, Japan, 701-1192
Actively Recruiting
191
Research Site
Osaka, Japan, 540-0008
Actively Recruiting
192
Research Site
Sapporo, Japan, 064-0804
Actively Recruiting
193
Research Site
Sendai, Japan, 980-8574
Actively Recruiting
194
Research Site
Sendai, Japan, 983-8520
Actively Recruiting
195
Research Site
Shinjuku-ku, Japan, 160-8582
Actively Recruiting
196
Research Site
Shinjuku-ku, Japan, 162-8655
Actively Recruiting
197
Research Site
Shinjuku-ku, Japan, 162-8666
Actively Recruiting
198
Research Site
Shiogama, Japan, 985-8506
Actively Recruiting
199
Research Site
Takamatsu, Japan, 760-0018
Actively Recruiting
200
Research Site
Takatsuiki-shi, Japan, 569-1096
Withdrawn
201
Research Site
Tanabe-shi, Japan, 646-8558
Actively Recruiting
202
Research Site
Toshima-ku, Japan, 171-0014
Withdrawn
203
Research Site
Ube, Japan, 755-8505
Actively Recruiting
204
Research Site
Yokohama, Japan, 236-0004
Actively Recruiting
205
Research Site
Yokohama, Japan, 245-8575
Withdrawn
206
Research Site
Eindhoven, Netherlands, 5623 EJ
Actively Recruiting
207
Research Site
Maastricht, Netherlands, 6229 HX
Not Yet Recruiting
208
Research Site
Rotterdam, Netherlands, 3045 PM
Actively Recruiting
209
Research Site
Rotterdam, Netherlands, 3083 AN
Actively Recruiting
210
Research Site
Zutphen, Netherlands, 7207 AE
Actively Recruiting
211
Research Site
Auckland, New Zealand, 0626
Actively Recruiting
212
Research Site
Auckland, New Zealand, 1051
Actively Recruiting
213
Research Site
Auckland, New Zealand, 2025
Actively Recruiting
214
Research Site
Hamilton West, New Zealand, 3204
Actively Recruiting
215
Research Site
Tauranga, New Zealand, 3112
Actively Recruiting
216
Research Site
Cusco, Peru, CUSCO 01
Not Yet Recruiting
217
Research Site
Lima, Peru, 15036
Not Yet Recruiting
218
Research Site
Lima, Peru, 15036
Withdrawn
219
Research Site
Lima, Peru, 15046
Actively Recruiting
220
Research Site
Lima, Peru, 15088
Actively Recruiting
221
Research Site
Lima, Peru, LIMA 01
Actively Recruiting
222
Research Site
Lima, Peru, LIMA 1
Actively Recruiting
223
Research Site
Lima, Peru, LIMA 21
Withdrawn
224
Research Site
Lima, Peru, LIMA 33
Actively Recruiting
225
Research Site
Piura, Peru, 20001
Actively Recruiting
226
Research Site
Bucharest, Romania, 011461
Withdrawn
227
Research Site
Bucharest, Romania, 050159
Suspended
228
Research Site
Cluj-Napoca, Romania, 400275
Actively Recruiting
229
Research Site
Cluj-Napoca, Romania, 400332
Actively Recruiting
230
Research Site
Oradea, Romania, 410176
Actively Recruiting
231
Research Site
Timișoara, Romania, 300002
Actively Recruiting
232
Research Site
Timișoara, Romania, 300310
Actively Recruiting
233
Research Site
Bellville, South Africa, 7530
Actively Recruiting
234
Research Site
Benoni, South Africa, 1501
Actively Recruiting
235
Research Site
Cape Town, South Africa, 7700
Actively Recruiting
236
Research Site
Durban, South Africa, 4001
Actively Recruiting
237
Research Site
Durban, South Africa, 4093
Actively Recruiting
238
Research Site
eMkhomazi, South Africa, 4170
Actively Recruiting
239
Research Site
Kimberley, South Africa, 8301
Actively Recruiting
240
Research Site
Somerset West, South Africa, 7130
Actively Recruiting
241
Research Site
Gothenburg, Sweden, 413 46
Actively Recruiting
242
Research Site
Karlskrona, Sweden, 371 79
Actively Recruiting
243
Research Site
Lund, Sweden, 22185
Actively Recruiting
244
Research Site
Örebro, Sweden, 703 62
Actively Recruiting
245
Research Site
Stockholm, Sweden, 11446
Actively Recruiting
246
Research Site
Stockholm, Sweden, 171 64
Actively Recruiting
247
Research Site
Bang Kra So, Thailand, 11000
Actively Recruiting
248
Research Site
Bangkok, Thailand, 10330
Actively Recruiting
249
Research Site
Hat Yai, Thailand, 90110
Actively Recruiting
250
Research Site
Muang, Thailand, 22000
Actively Recruiting
251
Research Site
Muang, Thailand, 40002
Actively Recruiting
252
Research Site
Mueang, Thailand, 20000
Actively Recruiting
253
Research Site
Rayong, Thailand, 21000
Actively Recruiting
254
Research Site
Adana, Turkey (Türkiye), 1330
Actively Recruiting
255
Research Site
Ankara, Turkey (Türkiye), 6620
Actively Recruiting
256
Research Site
Istanbul, Turkey (Türkiye), 34020
Actively Recruiting
257
Research Site
Kayseri, Turkey (Türkiye), 38039
Actively Recruiting
258
Research Site
Kocaeli, Turkey (Türkiye), 41380
Actively Recruiting
259
Research Site
Mersin, Turkey (Türkiye), 33079
Actively Recruiting
260
Research Site
Can Tho, Vietnam, 900000
Not Yet Recruiting
261
Research Site
Da Nang, Vietnam, 550000
Actively Recruiting
262
Research Site
Haiphong, Vietnam, 180000
Actively Recruiting
263
Research Site
Hanoi, Vietnam, 100000
Actively Recruiting
264
Research Site
Ho Chi Minh City, Vietnam, 700000
Actively Recruiting
265
Research Site
Ho Chi Minh City, Vietnam, 700000
Not Yet Recruiting
266
Research Site
Ho Chi Minh City, Vietnam
Not Yet Recruiting
267
Research Site
Hồ Chí Minh, Vietnam, 700000
Actively Recruiting
268
Research Site
Huế, Vietnam, 530000
Actively Recruiting
Research Team
A
AstraZeneca Clinical Study Information Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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