Actively Recruiting
A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)
Led by BeOne Medicines · Updated on 2026-05-11
630
Participants Needed
170
Research Sites
337 weeks
Total Duration
On this page
Sponsors
B
BeOne Medicines
Lead Sponsor
G
German CLL Study Group
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this study is to compare how well sonrotoclax plus obinutuzumab works versus venetoclax plus rituximab in treating adults with relapsed and/or refractory (R/R) chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). The study will also compare how well sonrotoclax plus rituximab works versus venetoclax plus rituxumab in treating adults with R/R CLL/SLL. The safety of these treatments will also be assessed.
CONDITIONS
Official Title
A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Confirmed diagnosis of CLL or SLL meeting iwCLL criteria
- Received one or more prior therapies for CLL/SLL, with at least 2 cycles per therapy
- Prior BCL2 inhibitor exposure allowed if remission lasted 3 or more years and last BCL2 inhibitor taken at least 2 years ago
- ECOG Performance Status of 0, 1, or 2
- Adequate organ function
You will not qualify if you...
- Known active prolymphocytic leukemia or suspected Richter's transformation
- Prior autologous stem cell transplant or CAR T-cell therapy within 3 months before first study drug dose
- Prior allogeneic stem cell transplant with active graft-versus-host disease or recent use of immunosuppressive drugs or calcineurin inhibitors
- Known central nervous system involvement by CLL/SLL
- Severe or debilitating lung disease
- Significant cardiovascular disease
- Other protocol-defined exclusion criteria may apply
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 170 locations
1
Uci Health Laguna Hills
Laguna Hills, California, United States, 92653
Actively Recruiting
2
Chao Family Comprehensive Cancer Center
Orange, California, United States, 92868-3201
Actively Recruiting
3
Stanford Cancer Institute
Palo Alto, California, United States, 94304-2205
Actively Recruiting
4
Scripps Prebys Cancer Center
San Diego, California, United States, 92103-2106
Actively Recruiting
5
Rocky Mountain Cancer Centers (Williams) Usor
Aurora, Colorado, United States, 80012-5405
Actively Recruiting
6
Yale University, Yale Cancer Center
New Haven, Connecticut, United States, 06520-8028
Actively Recruiting
7
Eastern Connecticut Hematology and Oncology
Norwich, Connecticut, United States, 06360-2700
Actively Recruiting
8
Cleveland Clinic Florida
Weston, Florida, United States, 33331-3609
Actively Recruiting
9
Northwestern University
Chicago, Illinois, United States, 60611
Actively Recruiting
10
Illinois Cancer Specialists (Niles) Usor
Niles, Illinois, United States, 60714-5905
Actively Recruiting
11
University of Louisville, Brown Cancer Center
Louisville, Kentucky, United States, 40202
Actively Recruiting
12
Mary Bird Perkins Cancer Center
Baton Rouge, Louisiana, United States, 70809-3738
Actively Recruiting
13
University of Maryland Greenebaum Comprehensive Cancer Center
Baltimore, Maryland, United States, 21201-1544
Actively Recruiting
14
Dana Farber Cancer Institute
Boston, Massachusetts, United States, 02215-5418
Actively Recruiting
15
The Cancer and Hematology Centers
Grand Rapids, Michigan, United States, 49503-2563
Actively Recruiting
16
Mayo Clinic Rochester
Rochester, Minnesota, United States, 55905-0001
Actively Recruiting
17
Sidney Kimmel Comprehensive Cancer Center Washington Twp
Sewell, New Jersey, United States, 08080
Actively Recruiting
18
Christus St Vincent Regional Cancer Center
Santa Fe, New Mexico, United States, 87505
Actively Recruiting
19
Memorial Sloan Kettering Cancer Center Mskcc
New York, New York, United States, 10065-6800
Actively Recruiting
20
Clinical Research Alliance, Inc
Westbury, New York, United States, 11590-5119
Actively Recruiting
21
University of North Carolina At Chapel Hill
Chapel Hill, North Carolina, United States, 27514-4220
Actively Recruiting
22
Levine Cancer Center
Charlotte, North Carolina, United States, 28204-2990
Actively Recruiting
23
Atrium Health Wake Forest Baptist
Winston-Salem, North Carolina, United States, 27157
Actively Recruiting
24
Oncology Hematology Care Clinical Trials, Llc
Cincinnati, Ohio, United States, 45245-1995
Actively Recruiting
25
Oncology Associates of Oregon Willamette Valley Cancer Center
Eugene, Oregon, United States, 97401
Actively Recruiting
26
Penn State Milton S Hershey Medical Center
Hershey, Pennsylvania, United States, 17033
Actively Recruiting
27
Thomas Jefferson University
Philadelphia, Pennsylvania, United States, 19107-4216
Actively Recruiting
28
Upmc Hillman Cancer Center(Univ of Pittsburgh)
Pittsburgh, Pennsylvania, United States, 15232-1309
Actively Recruiting
29
Tennessee Oncology Greco Hainsworth Centers For Research Chattanooga
Chattanooga, Tennessee, United States, 37404
Actively Recruiting
30
Tennessee Oncology
Nashville, Tennessee, United States, 37205
Actively Recruiting
31
Texas Oncology Baylorcharles A Sammons Cancer Center
Dallas, Texas, United States, 75246-2003
Actively Recruiting
32
Texas Oncology San Antonio Medical Center Usor
San Antonio, Texas, United States, 78240-5251
Actively Recruiting
33
Texas Oncology Tyler
Tyler, Texas, United States, 75702-7522
Actively Recruiting
34
Northwest Cancer Specialist, Pc(Us Oncology Research)
Vancouver, Washington, United States, 98684-6930
Actively Recruiting
35
FUNDALEU
Caba, Argentina, CP1114
Actively Recruiting
36
Instituto Alexander Fleming (Iaf)
Ciudad Autonoma Buenos Aires, Argentina, 1426
Actively Recruiting
37
Blacktown Cancer and Haematology Centre
Blacktown, New South Wales, Australia, NSW 2148
Actively Recruiting
38
St George Hospital
Kogarah, New South Wales, Australia, NSW 2217
Actively Recruiting
39
Northern Nsw Health District
Lismore, New South Wales, Australia, NSW 2480
Actively Recruiting
40
Macquarie University
North Ryde, New South Wales, Australia, NSW 2109
Actively Recruiting
41
Genesiscare North Shore
St Leonards, New South Wales, Australia, NSW 2065
Actively Recruiting
42
Sunshine Coast Hospital and Health Service
Birtinya, Queensland, Australia, QLD 4575
Actively Recruiting
43
Princess Alexandra Hospital
Woolloongabba, Queensland, Australia, QLD 4102
Actively Recruiting
44
Monash Health
Clayton, Victoria, Australia, VIC 3168
Actively Recruiting
45
St Vincents Hospital Melbourne
Fitzroy, Victoria, Australia, VIC 3065
Actively Recruiting
46
Peter Maccallum Cancer Centre
Melbourne, Victoria, Australia, VIC 3000
Actively Recruiting
47
The Alfred Hospital
Melbourne, Victoria, Australia, VIC 3004
Actively Recruiting
48
Rockingham Hospital
Cooloongup, Western Australia, Australia, WA 6168
Actively Recruiting
49
Perth Blood Institute
West Perth, Western Australia, Australia, WA 6005
Actively Recruiting
50
Medizinische Universitatsklinik Innsbruck
Innsbruck, Austria, 6020
Actively Recruiting
51
Medical University Vienna Oncology
Vienna, Austria, 1090
Actively Recruiting
52
Hanusch Krankenhaus
Vienna, Austria, 1140
Actively Recruiting
53
Cliniques Universitaires Saint Luc
Brussels, Belgium, 1200
Actively Recruiting
54
Uz Antwerpen
Edegem, Belgium, 2650
Actively Recruiting
55
University Hospitals Leuven
Leuven, Belgium, 3000
Actively Recruiting
56
CETUS
Belo Horizonte, Brazil, 30110-022
Active, Not Recruiting
57
Universidade de Campinas Centro de Hematologia E Hemoterapia
Campinas, Brazil, 13083-878
Active, Not Recruiting
58
Hospital Erasto Gaertner
Curitiba, Brazil, 81520-060
Active, Not Recruiting
59
Complexo Hospitalar de Niteroi
Niterói, Brazil, 24020-096
Active, Not Recruiting
60
Irmandade Da Santa Casa de Misericordia Hospital Porto Alegre
Porto Alegre, Brazil, 90020-090
Active, Not Recruiting
61
Hospital Sao Lucas
Rio de Janeiro, Brazil, 22061-080
Active, Not Recruiting
62
Instituto Dor de Pesquisa E Ensino Rio de Janeiro
Rio de Janeiro, Brazil, 22281-100
Active, Not Recruiting
63
Hospital Santa Izabel
Salvador, Brazil, 40050-410
Active, Not Recruiting
64
Hospital Samaritano Sao Paulo
São Paulo, Brazil, 01232-010
Active, Not Recruiting
65
Instituto Dor de Pesquisa E Ensino Sao Paulo
São Paulo, Brazil, 01401-004
Active, Not Recruiting
66
Hospital Nove de Julho Dasa
São Paulo, Brazil, 01409-001
Active, Not Recruiting
67
Instituto Brasileiro de Controle Do Cancer
São Paulo, Brazil, 04014-002
Active, Not Recruiting
68
Hcfmusp Servico de Hematologia, Hemoterapia E Terapia Celular
São Paulo, Brazil, 05402-000
Active, Not Recruiting
69
Hospital Santa Rita de Cassia Afecc
Vitória, Brazil, 29043-260
Active, Not Recruiting
70
Arthur Je Child Comprehensive Cancer Centre
Calgary, Alberta, Canada, T2N 5G2
Actively Recruiting
71
British Columbia Cancer Agency the Vancouver Centre
Vancouver, British Columbia, Canada, V5Z 4E6
Actively Recruiting
72
Newfoundland and Labrador Health Services
St. John's, Newfoundland and Labrador, Canada, A1B 3V6
Actively Recruiting
73
The Ottawa Hospital
Ottawa, Ontario, Canada, K1H 8L6
Actively Recruiting
74
Ciusss Nim Hscm
Montreal, Quebec, Canada, H4J 1C5
Actively Recruiting
75
Chu de Quebec Universite Laval, Hopital de Lenfant Jesus, Centre Integre de Cancerologie (Cic)
Québec, Canada, G1J 1Z4
Actively Recruiting
76
China Japan Friendship Hospital
Beijing, Beijing Municipality, China, 100029
Actively Recruiting
77
Fujian Provincial Hospital
Fuzhou, Fujian, China, 350001
Actively Recruiting
78
Fujian Medical University Union Hospitalqishan Branch
Fuzhou, Fujian, China, 350108
Actively Recruiting
79
The First Affiliated Hospital of Xiamen University
Xiamen, Fujian, China, 361003
Actively Recruiting
80
Guangzhou First Peoples Hospital
Guangzhou, Guangdong, China, 510013
Actively Recruiting
81
Nanfang Hospital, Southern Medical University
Guangzhou, Guangdong, China, 510515
Actively Recruiting
82
Guangxi Medical University Cancer Hospital Wuxiang Branch
Nanning, Guangxi, China, 530201
Actively Recruiting
83
The Second Hospital of Hebei Medical University
Shijiazhuang, Hebei, China, 050000
Actively Recruiting
84
Xiangya Hospital of Central South University
Changsha, Hunan, China, 410008
Actively Recruiting
85
The Affiliated Hospital of Inner Mongolia Medical University
Hohhot, Inner Mongolia, China, 010050
Actively Recruiting
86
Zhongda Hospital Southeast University
Nanjing, Jiangsu, China, 210009
Actively Recruiting
87
Suzhou Municipal Hospitalbaita Branch
Suzhou, Jiangsu, China, 215001
Actively Recruiting
88
Affiliated Hospital of Jiangnan University South Campus
Wuxi, Jiangsu, China, 214122
Actively Recruiting
89
Northern Jiangsu Peoples Hospital
Yangzhou, Jiangsu, China, 225001
Actively Recruiting
90
Jiangxi Cancer Hospital
Nanchang, Jiangxi, China, 330029
Actively Recruiting
91
Liaoning Cancer Hospital and Institute
Shenyang, Liaoning, China, 110042
Actively Recruiting
92
Shaanxi Provincial Peoples Hospital
Xi'an, Shaanxi, China, 710068
Actively Recruiting
93
Shandong Provincial Hospital
Jinan, Shandong, China, 250021
Actively Recruiting
94
Jining No1 Peoples Hospital West Branch
Jining, Shandong, China, 272000
Actively Recruiting
95
The Affiliated Hospital of Qingdao University Branch West Coast
Qingdao, Shandong, China, 266555
Actively Recruiting
96
Affiliated Zhongshan Hospital of Fudan University
Shanghai, Shanghai Municipality, China, 200032
Actively Recruiting
97
West China Hospital, Sichuan University
Chengdu, Sichuan, China, 610041
Actively Recruiting
98
The Affiliated Peoples Hospital of Ningbo University
Ningbo, Zhejiang, China, 315040
Actively Recruiting
99
Taizhou Hospital of Zhejiang Province (East)
Taizhou, Zhejiang, China, 317004
Actively Recruiting
100
Fakultni Nemocnice Brno
Brno, Czechia, 625 00
Actively Recruiting
101
Fakultni Nemocnice Hradec Kralove
Hradec Králové, Czechia, 500 03
Actively Recruiting
102
Vseobecna Fakultni Nemocnice V Praze
Prague, Czechia, 10000
Actively Recruiting
103
Ustav Hematologie A Krevni Transfuze (Uhkt)
Prague, Czechia, 128 00
Actively Recruiting
104
University Hospital of Aalborg
Aalborg, Denmark, 9000
Actively Recruiting
105
Rigshospitalet
Copenhagen, Denmark, 2100
Actively Recruiting
106
Odense University Hospital
Odense C, Denmark, 5000
Actively Recruiting
107
Zealand University Hospital, Roskilde
Roskilde, Denmark, 4000
Actively Recruiting
108
Chu Clermont Ferrand Therapie Cellulaire and Hematolo
Clermontferrand, France, 63100
Actively Recruiting
109
Centre Hospitalier Universitaire Nantes Hotel Dieu
Nantes, France, 44000
Actively Recruiting
110
Hopital de La Pitie Salpetriere
Paris, France, 75013
Actively Recruiting
111
Chu Hopital Lyon Sud
PierreBenite, France, 69495
Actively Recruiting
112
Hopital Robert Debre
Reims, France, 51100
Actively Recruiting
113
Chu Rennes
Rennes Cedes, France, 35000
Actively Recruiting
114
Centre Henri Becquerel
Rouen, France, 76038
Actively Recruiting
115
Iuct Oncopole
Toulouse, France, 31100
Actively Recruiting
116
Chu Nancy Hopital Brabois
VandoeuvrelesNancy, France, 54511
Actively Recruiting
117
Osp Kurfuerstendamm
Berlin, Germany, 10707
Actively Recruiting
118
Uniklinik Koeln (Aoer)
Cologne, Germany, 50937
Actively Recruiting
119
Gokos Gmbh
Dresden, Germany, 01307
Actively Recruiting
120
Universitatsklinikum Jena Klinik Fur Innere Medizin Ii
Jena, Germany, 07747
Actively Recruiting
121
Universitatsklinikum Schleswig Holstein, Campus Kiel
Kiel, Germany, 24105
Actively Recruiting
122
Stauferklinikum Schwabisch Gmund Kliniken Ostalb
Mutlangen, Germany, 73557
Actively Recruiting
123
Klinikum Der Universitat Munchen Medizinische Klinik Und Poliklinik Iii
München, Germany, 81377
Actively Recruiting
124
Dietrich Bonhoeffer Klinikum Neubrandenburg
Neubrandenburg, Germany, 17036
Actively Recruiting
125
Medizinische Universitaetsklinik
Tübingen, Germany, 72076
Actively Recruiting
126
Universitaetsklinikum Ulm
Ulm, Germany, 89081
Actively Recruiting
127
Haematologisch Onkologische Schwerpunktpraxis
Würzburg, Germany, 97080
Actively Recruiting
128
St Jamess Hospital
Dublin, Ireland, D08 NHY1
Actively Recruiting
129
Mater Misericordiae University Hospital
Dublin, Ireland, D7
Actively Recruiting
130
University Hospital Galway
Galway, Ireland, H91 YR71
Actively Recruiting
131
University Hospital Limerick
Limerick, Ireland, V94F858
Actively Recruiting
132
Azienda Ospedaliera Policlinico Di Bari
Bari, Italy, 70124
Actively Recruiting
133
Ao Brotzu Ospedale Oncologico Armando Businco
Cagliari, Italy, 09121
Actively Recruiting
134
Po Grodolico, Aou Policlinico Vittorio Emanuele Di Catania
Catania, Italy, 95123
Actively Recruiting
135
Azienda Ospedaliero Universitaria Di Ferrara
Ferrara, Italy, 44124
Actively Recruiting
136
Ospedale San Raffaele
Milan, Italy, 20132
Actively Recruiting
137
Universita Degli Studi Di Modena Azienda Ospedaliere Policlinco
Modena, Italy, 41124
Actively Recruiting
138
Asl Salerno Andrea Tortora
Pagani, Italy, 84014
Actively Recruiting
139
Flevoziekenhuis
Almere Stad, Netherlands, 1315 RA
Actively Recruiting
140
Rijnstate
Arnhem, Netherlands, 6815 AD
Actively Recruiting
141
Albert Schweitzer Ziekenhuis
Dordrecht, Netherlands, 3318 AT
Actively Recruiting
142
Tergooi Mc
Hilversum, Netherlands, 1212 VG
Actively Recruiting
143
North Shore Hospital
Auckland, New Zealand, 0622
Actively Recruiting
144
Auckland City Hospital
Auckland, New Zealand, 1023
Actively Recruiting
145
Wojewodzki Szpital Zespolony Im L Rydygiera W Toruniu
Torun, Poland, 87-100
Actively Recruiting
146
Pusan National University Hospital
Seogu, Busan Gwang'yeogsi, South Korea, 49241
Actively Recruiting
147
National Cancer Center (Korea)
IlsandongGu GoyangSi, Gyeonggi-do, South Korea, 10408
Actively Recruiting
148
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, South Korea, 13620
Actively Recruiting
149
Samsung Medical Center
GangnamGu, Seoul Teugbyeolsi, South Korea, 06351
Actively Recruiting
150
The Catholic University of Korea, Seoul St Marys Hospital
SeochoGu, Seoul Teugbyeolsi, South Korea, 06591
Actively Recruiting
151
Severance Hospital Yonsei University Health System
SeodaemunGu, Seoul Teugbyeolsi, South Korea, 03722
Actively Recruiting
152
Seoul National University Hospital
Seoul, Seoul Teugbyeolsi, South Korea, 03080
Actively Recruiting
153
Vall D Hebron Institute of Oncology Vhio
Barcelona, Spain, 08035
Actively Recruiting
154
Hospital Clinic de Barcelona
Barcelona, Spain, 08036
Actively Recruiting
155
Ico Lhospitalet Hospital Duran I Reynals
Lhospitalet de Llobregat, Spain, 08908
Actively Recruiting
156
Hospital de La Princesa
Madrid, Spain, 28006
Actively Recruiting
157
Hospital Universitario Infanta Leonor
Madrid, Spain, 28031
Actively Recruiting
158
Costa Del Sol (Marbella, Malaga)
Marbella, Spain, 29603
Actively Recruiting
159
Hospital Universitario de Salamanca
Salamanca, Spain, 37007
Actively Recruiting
160
Hospital Universitario Marques de Valdecilla
Santander, Spain, 39008
Actively Recruiting
161
Hospital Virgen de Valme (Sevilla)
Seville, Spain, 41014
Actively Recruiting
162
Sahlgrenska University Hospital Hematology
Gothenburg, Sweden, 413 46
Actively Recruiting
163
Skanes Universitetssjukhus I Lund
Lund, Sweden, 221 85
Actively Recruiting
164
Karolinska Universitetssjukhuset Solna
Stockholm, Sweden, 171 76
Actively Recruiting
165
Uppsala Akademiska Sjukhus
Uppsala, Sweden, 751 85
Actively Recruiting
166
University Hospitals Dorset Royal Bournemouth Hospital
Bournemouth, United Kingdom, BH7 7DW
Actively Recruiting
167
Kings College Hospital
London, United Kingdom, SE5 9RS
Actively Recruiting
168
Clatterbridge Cancer Centre
Metropolitan Borough of Wirral, United Kingdom, CH63 4JY
Actively Recruiting
169
Freeman Hospital
Newcastle upon Tyne, United Kingdom, NE7 7DN
Actively Recruiting
170
Royal Cornwall Hospitalsnhs Trust
Truro, United Kingdom, TR1 3LJ
Actively Recruiting
Research Team
S
Study Director
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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