Actively Recruiting
A Study to Investigate the Safety and Efficacy of GSK4532990 Compared With Placebo in Adult Participants Aged 18 to 70 Years With Alcohol-related Liver Disease
Led by GlaxoSmithKline · Updated on 2026-04-01
393
Participants Needed
131
Research Sites
179 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this study is to assess the safety and efficacy of GSK4532990 in participants with alcohol-related liver disease.
CONDITIONS
Official Title
A Study to Investigate the Safety and Efficacy of GSK4532990 Compared With Placebo in Adult Participants Aged 18 to 70 Years With Alcohol-related Liver Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Capable of giving signed informed consent prior to the performance of any study-specific procedures.
- Able and willing to comply with all study assessments and adhere to the protocol schedule of activities.
- In the opinion of the investigator, there is a history of alcohol consumption compatible with either ALD or Met ALD.
- A female participant is eligible to participate after meeting additional pre-defined criteria.
- Participants must meet predefined stable use requirements of concomitant medications based on study criteria.
- Participant has advanced chronic liver disease
You will not qualify if you...
- Meeting any definition of organ system failure as defined by the North American Consortium for Study of End-stage Liver Disease (NACSELD)
- Exceeding pre-defined biochemical parameters for Alanine Aminotransferase (ALT), Aspartate aminotransferase (AST), Alkaline Phosphatase (ALP), Platelets, International normalised ratio (INR), Albumin, estimated glomerular filtration rate (eGFR), Urine albumin-creatinine ratio (UACR) or Glycosylated Hemoglobin (HbA1c). Other primary causes of liver disease based on study criteria.
- Current malignancy (except for basal cell carcinoma or uterine carcinoma-in-situ) at screening. Participants under evaluation for possible malignancy at screening are not eligible.
- Prior organ transplant or current listing or active consideration for organ transplant during the screening period (except for corneal transplants).
- Chronic or acute, including partial, known portal vein thrombosis.
- Prior transjugular intrahepatic portosystemic shunt (TIPSS) insertion.
- Any acute cardiovascular event including myocardial infarction, unstable angina, symptomatic heart failure, or cerebrovascular accident in the 6 months prior to screening.
- Poorly controlled hypertension
- Clinical suspicion of rhabdomyolysis during the screening period
- Clinical suspicion of a bleeding episode during the screening period related to portal hypertension and/or low blood fibrinogen level.
- Body Mass Index (BMI) >35 kg/m2 at screening
- Any liver-related clinical event that started (onset) <8 weeks prior to Baseline (D1).
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 131 locations
1
GSK Investigational Site
Chandler, Arizona, United States, 85224
Actively Recruiting
2
GSK Investigational Site
Phoenix, Arizona, United States, 85006
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3
GSK Investigational Site
Tucson, Arizona, United States, 85715
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4
GSK Investigational Site
Davis, California, United States, 95817
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5
GSK Investigational Site
Los Angeles, California, United States, 90033
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6
GSK Investigational Site
Los Angeles, California, United States, 90048
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7
GSK Investigational Site
Brandon, Florida, United States, 33511
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8
GSK Investigational Site
Miami Lakes, Florida, United States, 33016
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9
GSK Investigational Site
Atlanta, Georgia, United States, 30309
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10
GSK Investigational Site
Indianapolis, Indiana, United States, 46202
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11
GSK Investigational Site
Topeka, Kansas, United States, 66606
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12
GSK Investigational Site
Marrero, Louisiana, United States, 70072
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13
GSK Investigational Site
Detroit, Michigan, United States, 48202
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14
GSK Investigational Site
Las Vegas, Nevada, United States, 89106
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15
GSK Investigational Site
New York, New York, United States, 10029
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16
GSK Investigational Site
Chapel Hill, North Carolina, United States, 27514
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17
GSK Investigational Site
Cleveland, Ohio, United States, 44195
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18
GSK Investigational Site
Philadelphia, Pennsylvania, United States, 19014
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19
GSK Investigational Site
Arlington, Texas, United States, 76012
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20
GSK Investigational Site
Austin, Texas, United States, 78757
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21
GSK Investigational Site
Dallas, Texas, United States, 75203
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22
GSK Investigational Site
Dallas, Texas, United States, 75235
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23
GSK Investigational Site
Georgetown, Texas, United States, 78626
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24
GSK Investigational Site
McAllen, Texas, United States, 78503
Completed
25
GSK Investigational Site
San Antonio, Texas, United States, 78215
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26
GSK Investigational Site
Richmond, Virginia, United States, 23219
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27
GSK Investigational Site
Richmond, Virginia, United States, 23249
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28
GSK Investigational Site
Buenos Aires, Argentina, 1425
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29
GSK Investigational Site
Buenos Aires, Argentina, C1061AAS
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30
GSK Investigational Site
Buenos Aires, Argentina, C1181ACH
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31
GSK Investigational Site
Buenos Aires, Argentina
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32
GSK Investigational Site
Ciudad AutOnoma de Buenos Aire, Argentina, 1118
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33
GSK Investigational Site
Ciudad Autonoma de Buenos Aire, Argentina, 1426
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34
GSK Investigational Site
Rosario, Argentina, S2002
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35
GSK Investigational Site
San Miguel de Tucumán, Argentina, T4000IHE
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36
GSK Investigational Site
Adelaide, South Australia, Australia, 5000
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37
GSK Investigational Site
Melbourne, Victoria, Australia, 3004
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38
GSK Investigational Site
Parkville Melbourne, Victoria, Australia, 3050
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39
GSK Investigational Site
Murdoch, Western Australia, Australia, 6150
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40
GSK Investigational Site
Perth, Western Australia, Australia, 6000
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41
GSK Investigational Site
Calgary, Alberta, Canada, T2N 4Z6
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42
GSK Investigational Site
New Westminster, British Columbia, Canada, V3L 3W4
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43
GSK Investigational Site
Vancouver, British Columbia, Canada, V6Z 2K5
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44
GSK Investigational Site
London, Ontario, Canada, N6A 5A5
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45
GSK Investigational Site
Toronto, Ontario, Canada, M1S 4T7
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46
GSK Investigational Site
Toronto, Ontario, Canada, M5G 2C4
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47
GSK Investigational Site
Montreal, Quebec, Canada, H2X 0A9
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48
GSK Investigational Site
Terrebonne, Quebec, Canada, J6X 4P7
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49
GSK Investigational Site
Esbjerg, Denmark, 6700
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50
GSK Investigational Site
Hvidovre, Denmark, 2650
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51
GSK Investigational Site
Odense C, Denmark, 5000
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52
GSK Investigational Site
Angers, France, 49933
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53
GSK Investigational Site
Bobigny, France, 93000
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54
GSK Investigational Site
Créteil, France, 94000
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55
GSK Investigational Site
Lille, France, 59037
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56
GSK Investigational Site
Montpellier, France, 34295
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57
GSK Investigational Site
Rouen, France, 76031
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58
GSK Investigational Site
Bochum, North Rhine-Westphalia, Germany, 44892
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59
GSK Investigational Site
Berlin, Germany, 10787
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60
GSK Investigational Site
Berlin, Germany, 13353
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61
GSK Investigational Site
Kiel, Germany, 24105
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62
GSK Investigational Site
Leipzig, Germany, 04103
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63
GSK Investigational Site
Mainz, Germany, 55101
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64
GSK Investigational Site
Athens, Greece, 10676
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65
GSK Investigational Site
Athens, Greece, 11527
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66
GSK Investigational Site
Athens, Greece, 11527
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67
GSK Investigational Site
Bergamo, Italy, 24127
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68
GSK Investigational Site
Bologna, Italy, 40138
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69
GSK Investigational Site
Messina, Italy, 98124
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70
GSK Investigational Site
Milan, Italy, 20122
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71
GSK Investigational Site
Milan, Italy, 20142
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72
GSK Investigational Site
Milan, Italy, 20162
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73
GSK Investigational Site
Padova, Italy, 35131
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74
GSK Investigational Site
Roma, Italy, 00128
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75
GSK Investigational Site
Roma, Italy, 00168
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76
GSK Investigational Site
Chiba, Japan, 286-8520
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77
GSK Investigational Site
Ehime, Japan, 790-0024
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78
GSK Investigational Site
Gunma, Japan, 371-8511
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79
GSK Investigational Site
Hokkaido, Japan, 060-0033
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80
GSK Investigational Site
Kagawa, Japan, 760-0017
Withdrawn
81
GSK Investigational Site
Kagawa, Japan, 761-0793
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82
GSK Investigational Site
Nara, Japan, 634-8522
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83
GSK Investigational Site
Niigata, Japan, 951-8520
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84
GSK Investigational Site
Osaka, Japan, 545-8586
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85
GSK Investigational Site
Osaka, Japan, 564-0013
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86
GSK Investigational Site
Osaka, Japan, 565-0871
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87
GSK Investigational Site
Saitama, Japan, 350-0495
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88
GSK Investigational Site
Shizuoka, Japan, 431-3192
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89
GSK Investigational Site
Tokyo, Japan, 180-8610
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90
GSK Investigational Site
DF, Mexico, 14080
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91
GSK Investigational Site
Mexico City, Mexico, 11510
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92
GSK Investigational Site
Monterrey, Mexico, 66260
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93
GSK Investigational Site
Katowice, Poland, 40-600
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94
GSK Investigational Site
Mysłowice, Poland, 41-400
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95
GSK Investigational Site
Warsaw, Poland, 00-124
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96
GSK Investigational Site
Johannesburg, South Africa, 2193
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97
GSK Investigational Site
Ansan, South Korea, 15355
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98
GSK Investigational Site
Bucheon-si, South Korea
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99
GSK Investigational Site
Daegu, South Korea, 700-721
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100
GSK Investigational Site
Seoul, South Korea, 02447
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101
GSK Investigational Site
Seoul, South Korea, 06351
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102
GSK Investigational Site
Seoul, South Korea, 07061
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103
GSK Investigational Site
Seoul, South Korea, 138-736
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104
GSK Investigational Site
Suwon Gyeonggi-do, South Korea, 442-723
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105
GSK Investigational Site
Barcelona, Spain, 08003
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106
GSK Investigational Site
Barcelona, Spain, 08035
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107
GSK Investigational Site
Barcelona, Spain, 08036
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108
GSK Investigational Site
León, Spain, 24071
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109
GSK Investigational Site
Madrid, Spain, 28006
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110
GSK Investigational Site
Madrid, Spain, 28007
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111
GSK Investigational Site
Madrid, Spain, 28041
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112
GSK Investigational Site
Santander, Spain, 39011
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113
GSK Investigational Site
Seville, Spain, 41013
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114
GSK Investigational Site
Valencia, Spain, 46014
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115
GSK Investigational Site
Valladolid, Spain, 47003
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116
GSK Investigational Site
Vigo, Spain, 36071
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117
GSK Investigational Site
Stockholm, Sweden, SE-141 86
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118
GSK Investigational Site
Uppsala, Sweden, 751 85
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119
GSK Investigational Site
Kocaeli, İzmit, Turkey (Türkiye), 41001
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120
GSK Investigational Site
Diyarbakır, Sur, Turkey (Türkiye), 21280
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121
GSK Investigational Site
Adana, Yüreğir, Turkey (Türkiye), 01230
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122
GSK Investigational Site
Istanbul, Turkey (Türkiye), 34010
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123
GSK Investigational Site
Bristol, United Kingdom, BS10 5NB
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124
GSK Investigational Site
Cambridge, United Kingdom, CB2 0QQ
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125
GSK Investigational Site
Glasgow Strathclyde, United Kingdom, G51 4TF
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126
GSK Investigational Site
Leeds West Yorkshire, United Kingdom, LS9 7TF
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127
GSK Investigational Site
Liverpool, United Kingdom, L9 7AL
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128
GSK Investigational Site
London, United Kingdom, NW3 2QG
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129
GSK Investigational Site
London, United Kingdom, W2 1NY
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130
GSK Investigational Site
Middlesbrough, United Kingdom, TS4 3BW
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131
GSK Investigational Site
Plymouth, United Kingdom, PL6 5FP
Actively Recruiting
Research Team
U
US GSK Clinical Trials Call Center
CONTACT
E
EU GSK Clinical Trials Call Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
NA
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
5
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