Actively Recruiting
A Study to Investigate the Safety and Efficacy of MEDI0618 Compared to Placebo in Adult Participants With Episodic Migraine
Led by AbbVie · Updated on 2026-01-22
488
Participants Needed
54
Research Sites
134 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this Phase 2 study is to evaluate the safety and efficacy of SC MEDI0618 compared to placebo in participants with episodic migraine.
CONDITIONS
Official Title
A Study to Investigate the Safety and Efficacy of MEDI0618 Compared to Placebo in Adult Participants With Episodic Migraine
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 70 years
- Weight at least 40 kg and BMI at least 18.0 kg/m2
- History of migraine headaches with or without aura, starting at age 50 or younger, lasting at least 12 months
- At least 12 migraine headache days in the 3 months before screening
- Between 4 and 14 migraine headache days per month during 4 weeks of baseline data collection
- On at least 4 days, migraine headache must meet specific criteria including migraine without aura or with aura, probable migraine, or respond to migraine-specific medication
- Participants with medication overuse headache (MOH) are eligible
- History of unsuccessful treatment with at least 2 small molecule migraine preventive treatments from different classes
- For participants eligible for aCGRP therapy but who have not yet received it
- For participants who have tried and failed at least one aCGRP therapy for prevention
- Ability to distinguish migraine headaches from tension-type headaches
- Female participants must not be pregnant, lactating, or planning pregnancy during the study, or be of nonchildbearing potential
- Female participants of childbearing potential who are sexually active with a non-sterilized male partner must use two highly effective contraception methods during the study and 10 weeks after last dose
- Female participants of childbearing potential must agree to follow safe administration guidelines and avoid egg donation and in vitro fertilization during and after the study
You will not qualify if you...
- History of specific migraine types: hemiplegic, ophthalmoplegic, or basilar-type migraine
- Headache other than migraine within 3 months before screening
- Severe or ongoing allergy or hypersensitivity reactions, or history of hypersensitivity to immunisations or immunoglobulins
- Significant psychiatric disorders that could impact safety or data
- Clinically significant illnesses like cardiovascular, neurologic (except allowed headaches), pulmonary, hepatic, renal, metabolic, gastrointestinal, urologic, immunologic, or endocrine diseases
- History of cancer within 5 years before screening except certain skin, cervical, or prostate cancers
- Known drug or alcohol abuse within 1 year before screening or positive drug/alcohol test at screening
- History of prolonged QT interval or congenital QT syndrome
- History of symptomatic or treated arrhythmias, except controlled atrial fibrillation
- Use of migraine preventive medications within 30 days or 5 half-lives prior to screening and during study
- Prior use of aCGRP therapy for acute or preventive treatment (for aCGRP-N participants)
- Use of opioids or barbiturate analgesics more than twice a month in last 6 months, except emergency use
- Use of botulinum toxin injections in head, face, or neck within 4 months before screening
- Use of migraine treatment devices or interventions within 2 months before screening
- Use of prescription or non-prescription non-biologic drugs within 7 days or 5 half-lives before screening unless stable and safe
- Need for another biological therapeutic agent during study
- Recent participation in other clinical studies with investigational products or devices
- Known hypersensitivity to MEDI0618 or its ingredients
- Other protocol-specific inclusion and exclusion criteria may apply
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 54 locations
1
Flourish - Birmingham
Birmingham, Alabama, United States, 35205
Actively Recruiting
2
Tennessee Valley Neurological Associates PC
Huntsville, Alabama, United States, 35801
Withdrawn
3
The Neurology Center of Southern California - Carlsbad Office
La Jolla, California, United States, 92037
Actively Recruiting
4
Clinical Research Institute, LCC
Los Angeles, California, United States, 90048
Actively Recruiting
5
Homestead Associates in Research, Inc.
Homestead, Florida, United States, 33033
Not Yet Recruiting
6
Florida Neurology - Lake Mary
Lake Mary, Florida, United States, 32746
Not Yet Recruiting
7
Flourish Research - Miami, LLC dba Flourish Research
Miami, Florida, United States, 33135
Actively Recruiting
8
BayCare Medical Group Neurology at St. Anthony's Hospital
St. Petersburg, Florida, United States, 33705
Not Yet Recruiting
9
Santos Research Center, Corp - Tampa
Tampa, Florida, United States, 33615
Actively Recruiting
10
Norton Neuroscience Institute - Headache Clinic
Louisville, Kentucky, United States, 40207
Withdrawn
11
Modern Migraine, MD
New York, New York, United States, 10001
Withdrawn
12
Velocity Clinical Research, Providence (East Greenwich)
East Greenwich, Rhode Island, United States, 02818
Not Yet Recruiting
13
Palmetto Primary Care Physicians Division of Gastroenterology - Summerville
Summerville, South Carolina, United States, 29486
Actively Recruiting
14
FutureSearch Trials
Austin, Texas, United States, 78731
Actively Recruiting
15
Vaught Neurological Services, PLLC
Crab Orchard, West Virginia, United States, 25827
Not Yet Recruiting
16
The Mind+ Neurology Clinic
Mequon, Wisconsin, United States, 53092
Actively Recruiting
17
Brain-Soultherapy s.r.o.
Kladno, Czechia, 272 01
Not Yet Recruiting
18
Clintrial s.r.o.
Prague, Czechia, 100 00
Not Yet Recruiting
19
DADO Medical s.r.o.
Prague, Czechia, 120 00
Not Yet Recruiting
20
Axon Clinical s.r.o.
Prague, Czechia, 150 00
Not Yet Recruiting
21
Praglandia s.r.o.
Prague, Czechia, 150 00
Not Yet Recruiting
22
Forbeli s.r.o
Prague, Czechia, 160 00
Not Yet Recruiting
23
Institut Neuropsychiatricke Pece (INEP)
Prague, Czechia, 186 00
Not Yet Recruiting
24
Vestra Clinics s.r.o.
Rychnov nad Kněžnou, Czechia, 266 55
Not Yet Recruiting
25
Rigshospitalet (Copenhagen University Hospital) - Dansk Hovedpinecenter (Danish Headache Center)
Glostrup Municipality, Denmark, 2600
Not Yet Recruiting
26
Charite-Universitaetsmedizin Berlin - Campus Charite Mitte (CCM) - Klinik fuer Neurologie
Berlin, Germany, 10117
Not Yet Recruiting
27
Pharmakologisches Studienzentrum Chemnitz GmbH
Chemnitz, Germany, 09111
Not Yet Recruiting
28
Universitätsklinikum Carl Gustav Carus Dresden
Dresden, Germany, 01307
Not Yet Recruiting
29
Universitätsklinikum Essen
Essen, Germany, 45147
Not Yet Recruiting
30
Kopfschmerzzentrum Frankfurt
Frankfurt am Main, Germany, 65929
Not Yet Recruiting
31
Fachuebergreifende Gemeinschaftspraxis Dr. med. Joachim Springub & Wolfgang Schwarz
Westerstede, Germany, 26655
Not Yet Recruiting
32
Óbudai Egészségügyi Centrum
Budapest, Hungary, 1036
Not Yet Recruiting
33
S-Medicon Kft.
Budapest, Hungary, 1138
Not Yet Recruiting
34
Obudai Egeszsegugyi Centrum - Dunaujvaros
Dunaújváros, Hungary, 2400
Not Yet Recruiting
35
IRCCS Ospedale San Raffaele
Milan, Italy, 20132
Not Yet Recruiting
36
IRCCS Fondazione Istituto Neurologico Nazionale Casimiro Mondino
Pavia, Italy, 27100
Not Yet Recruiting
37
Policlinico Universitario Campus Bio-Medico
Roma, Italy, 00128
Not Yet Recruiting
38
IRCCS San Raffaele Pisana
Roma, Italy, 00163
Not Yet Recruiting
39
Centrum Medyczne Pratia Bydgoszcz
Bydgoszcz, Poland, 85-796
Not Yet Recruiting
40
Centrum Medyczne Pratia - Katowice
Katowice, Poland, 40-081
Not Yet Recruiting
41
Specjalistyczne Gabinety Sp. z o.o.
Krakow, Poland, 30-539
Not Yet Recruiting
42
FutureMeds Sp. z.o.o.
Krakow, Poland, 31-501
Not Yet Recruiting
43
Centrum Medyczne Hope Clinic
Lublin, Poland, 20-701
Not Yet Recruiting
44
Solumed Centrum Medyczne
Poznan, Poland, 60-529
Not Yet Recruiting
45
Centrum Medyczne HCP Sp. z o.o.
Poznan, Poland, 61-485
Not Yet Recruiting
46
FutureMeds Warszawa Centrum
Warsaw, Poland, 00-215
Not Yet Recruiting
47
MTZ Clinical Research Sp. z o.o.
Warsaw, Poland, 02-172
Not Yet Recruiting
48
European Trial Group (ETG) - Warszawa
Warsaw, Poland, 02-677
Actively Recruiting
49
Hospital Universitario de Badajoz
Badajoz, Spain, 06080
Not Yet Recruiting
50
Hospital del Mar
Barcelona, Spain, 08003
Not Yet Recruiting
51
Hospital Universitari Vall d'Hebron - Institut de Recerca (VHIR)
Barcelona, Spain, 08035
Not Yet Recruiting
52
Hospital Universitario La Paz
Madrid, Spain, 28046
Not Yet Recruiting
53
Hospital Clinico Universitario de Valencia
Valencia, Spain, 46010
Not Yet Recruiting
54
Hospital Universitari i Politècnic La Fe
Valencia, Spain, 46026
Not Yet Recruiting
Research Team
A
ABBVIE CALL CENTER
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
7
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here