Actively Recruiting

Phase 3
Age: 3Months - 23Months
All Genders
NCT07265479

A Study to Investigate Safety and Efficacy of Tapinarof Cream, 1% in Participants Ages 3 Months to < 24 Months With Atopic Dermatitis

Led by Organon and Co · Updated on 2026-05-14

180

Participants Needed

47

Research Sites

104 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The purpose of this global Phase 3 clinical study is to investigate the safety and efficacy of tapinarof cream, 1% in participants ages 3 months to 23 months (inclusive) with atopic dermatitis.

CONDITIONS

Official Title

A Study to Investigate Safety and Efficacy of Tapinarof Cream, 1% in Participants Ages 3 Months to < 24 Months With Atopic Dermatitis

Who Can Participate

Age: 3Months - 23Months
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Infants and toddlers born at term (≥37 weeks of gestational age) who are 3 months to less than 24 months old at Screening
  • Clinical diagnosis of atopic dermatitis covering more than 5% of body surface area
  • Validated Investigator Global Assessment for Atopic Dermatitis (vIGA-AD) score of 2, 3, or 4
  • Legal guardian or primary caregiver willing and able to sign informed consent before any study activities
  • Legal guardian or primary caregiver able and willing to follow protocol requirements
Not Eligible

You will not qualify if you...

  • Significant neurological disorder or history of seizures
  • Known clinically significant cardiac rhythm or cardiac disorder
  • History of sudden infant death in a sibling
  • Clinically significant chromosome abnormality
  • History of or ongoing serious illness or medical, physical, or psychiatric conditions that may interfere with participation
  • Diseases causing itching and/or sleep disruption
  • Immunocompromised status
  • Current chronic or acute infection requiring treatment
  • Use of prohibited medications or procedures
  • Use of prohibited medications by breastfeeding mother if participant is breastfeeding

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 47 locations

1

AllerVie Clinical Research

Birmingham, Alabama, United States, 35209

Actively Recruiting

2

Dermatology Trial Associates

Bryant, Arkansas, United States, 72022

Actively Recruiting

3

Dermatology Research Associates

Los Angeles, California, United States, 90045

Actively Recruiting

4

Integrative Skin Science and Research

Sacramento, California, United States, 95815

Actively Recruiting

5

Allergy and Asthma Medical Group and Research Center

San Diego, California, United States, 92123

Actively Recruiting

6

Clinical Trials Research Institute

Thousand Oaks, California, United States, 91320

Actively Recruiting

7

Clarity Dermatology

Castle Rock, Colorado, United States, 80109

Actively Recruiting

8

Skin Care Research, LLC.

Boca Raton, Florida, United States, 33486

Actively Recruiting

9

APEX Clinical Trials

Jacksonville, Florida, United States, 32256

Actively Recruiting

10

TruDerm Research

Wellington, Florida, United States, 33449

Actively Recruiting

11

Cleaver Medical Group Dermatology, Inc

Cumming, Georgia, United States, 30040

Actively Recruiting

12

Ada West Research

Meridian, Idaho, United States, 83646

Actively Recruiting

13

Endeavor Health Clinical Trials Center

Skokie, Illinois, United States, 60077

Actively Recruiting

14

Dawes Fretzin Clinical Research Group, LLC

Indianapolis, Indiana, United States, 46250

Actively Recruiting

15

The Indiana Clinical Trials Center, PC

Plainfield, Indiana, United States, 46168

Actively Recruiting

16

Equity Medical, LLC

Bowling Green, Kentucky, United States, 42104

Actively Recruiting

17

Lawrence J Green, MD LLC

Rockville, Maryland, United States, 20850

Actively Recruiting

18

Oakland Hills Dermatology

Auburn Hills, Michigan, United States, 48326

Actively Recruiting

19

Minnesota Clinical Study Center

New Brighton, Minnesota, United States, 55112

Actively Recruiting

20

SKY Integrative Medical Center

Ridgeland, Mississippi, United States, 39157

Actively Recruiting

21

MediSearch Clinical Trials

Saint Joseph, Missouri, United States, 64506

Actively Recruiting

22

Skin Cancer and Dermatology Institute

Reno, Nevada, United States, 89509

Actively Recruiting

23

Forest Hills Dermatology Group

Kew Gardens, New York, United States, 11415

Actively Recruiting

24

Bobby Buka MD, PC

New York, New York, United States, 10012

Actively Recruiting

25

Equity Medical, LLC

The Bronx, New York, United States, 10455

Actively Recruiting

26

The University of North Carolina Dermatology and Skin Cancer Center

Chapel Hill, North Carolina, United States, 27516

Actively Recruiting

27

Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, United States, 45229

Not Yet Recruiting

28

Dermatologists of Central States, LLC

Fairborn, Ohio, United States, 45324

Actively Recruiting

29

Allergy Asthma and Clinical Research Center

Oklahoma City, Oklahoma, United States, 73120

Actively Recruiting

30

Oregon Dermatology and Research Center

Portland, Oregon, United States, 97210

Actively Recruiting

31

Oregon Health & Science University

Portland, Oregon, United States, 97239

Not Yet Recruiting

32

Medical University of South Carolina

Charleston, South Carolina, United States, 29425

Actively Recruiting

33

National Allergy and Asthma Research, LLC.

North Charleston, South Carolina, United States, 29420

Actively Recruiting

34

The University of Texas Health Science Center at Houston

Bellaire, Texas, United States, 77401

Actively Recruiting

35

Dermatology Treatment and Research Center

Dallas, Texas, United States, 75230

Actively Recruiting

36

Stryde Research - Epiphany Dermatology

Southlake, Texas, United States, 76092

Actively Recruiting

37

Dermatology Specialists of Spokane

Spokane, Washington, United States, 99202

Actively Recruiting

38

Dermatology Research Institute

Calgary, Alberta, Canada, T2J 7E1

Actively Recruiting

39

CARe Clinic (Central Alberta Research Clinic)

Red Deer, Alberta, Canada, T4P 1K4

Actively Recruiting

40

Dr. Chih-Ho Hong Medical Inc.

Surrey, British Columbia, Canada, V3R 6A7

Actively Recruiting

41

Manitoba Allergy Research Inc.

Winnipeg, Manitoba, Canada, R3J 0S9

Actively Recruiting

42

Maritime Dermatology

Halifax, Nova Scotia, Canada, B3K 5R3

Actively Recruiting

43

Halton Pediatric Allergy

Burlington, Ontario, Canada, L7L 6W6

Actively Recruiting

44

Triple A Lab Inc.

Hamilton, Ontario, Canada, L8S 1G5

Actively Recruiting

45

Allergy Research Canada Inc.

Niagara Falls, Ontario, Canada, L2H 1C4

Actively Recruiting

46

Dr. Rachel Asiniwasis Medical Professional Corporation

Regina, Saskatchewan, Canada, S4V 1R9

Active, Not Recruiting

47

Skinsense Medical Research

Saskatoon, Saskatchewan, Canada, S7K 2C1

Actively Recruiting

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Research Team

C

Clinical Lead Late-Stage Clinical Development

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

QUADRUPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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