Actively Recruiting
A Study to Investigate Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Acalabrutinib in Adults With Previously Untreated Chronic Lymphocytic Leukemia
Led by BeOne Medicines · Updated on 2026-05-11
500
Participants Needed
29
Research Sites
301 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to investigate the efficacy and safety of fixed-duration sonrotoclax (also known as BGB-11417) plus zanubrutinib (also known as BGB-3111) (SZ) compared with fixed-duration of venetoclax plus acalabrutinib (AV) in participants with previously untreated chronic lymphocytic leukemia (CLL).
CONDITIONS
Official Title
A Study to Investigate Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Acalabrutinib in Adults With Previously Untreated Chronic Lymphocytic Leukemia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults with confirmed chronic lymphocytic leukemia requiring treatment
- No prior treatment for CLL
- Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2
- Measurable disease by CT or MRI scans
- Adequate bone marrow and organ function
You will not qualify if you...
- Previous systemic treatment for chronic lymphocytic leukemia
- Known prolymphocytic leukemia or history or suspicion of Richter's transformation
- Known involvement of the central nervous system
- History of progressive multifocal leukoencephalopathy (PML)
- Uncontrolled high blood pressure or significant cardiovascular disease
- Other protocol-defined exclusion criteria may apply
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 29 locations
1
Blacktown Cancer and Haematology Centre
Blacktown, New South Wales, Australia, NSW 2148
Actively Recruiting
2
Concord Repatriation General Hospital
Concord, New South Wales, Australia, NSW 2139
Actively Recruiting
3
Genesiscare North Shore
St Leonards, New South Wales, Australia, NSW 2065
Actively Recruiting
4
Princess Alexandra Hospital
Woolloongabba, Queensland, Australia, QLD 4102
Actively Recruiting
5
Monash Health
Clayton, Victoria, Australia, VIC 3168
Actively Recruiting
6
Austin Health
Heidelberg, Victoria, Australia, VIC 3084
Actively Recruiting
7
Cabrini Hospital Malvern
Malvern East, Victoria, Australia, VIC 3144
Actively Recruiting
8
The Alfred Hospital
Melbourne, Victoria, Australia, VIC 3004
Actively Recruiting
9
Instituto Dor de Pesquisa E Ensino Distrito Federal
Brasília, Brazil, 70390140
Actively Recruiting
10
Centro Gaucho Integrado de Oncologia Hospital Mae de Deus
Porto Alegre, Brazil, 90110-270
Actively Recruiting
11
Instituto Dor de Pesquisa E Ensino Sao Paulo
São Paulo, Brazil, 01401-004
Actively Recruiting
12
Ciusss Nim Hscm
Montreal, Quebec, Canada, H4J 1C5
Actively Recruiting
13
Jewish General Hospital
Montreal, Quebec, Canada, QC H3t 1E2
Actively Recruiting
14
Ciusss de Lestrie Chus
Sherbrooke, Quebec, Canada, J1H 5N4
Actively Recruiting
15
Chu de Quebec Universite Laval, Hopital de Lenfant Jesus, Centre Integre de Cancerologie (Cic)
Québec, Canada, G1J 1Z4
Actively Recruiting
16
Zhujiang Hospital of Southern Medical University
Guangzhou, Guangdong, China, 510000
Actively Recruiting
17
Jiangsu Province Hospital
Nanjing, Jiangsu, China, 210029
Actively Recruiting
18
The Second Affiliated Hospital of Xian Jiaotong University
Xi'an, Shaanxi, China, 710004
Actively Recruiting
19
North Shore Hospital
Auckland, New Zealand, 0622
Actively Recruiting
20
Auckland City Hospital
Auckland, New Zealand, 1023
Actively Recruiting
21
Health New Zealand Canterbury
Christchurch, New Zealand, 8011
Actively Recruiting
22
Wellington Regional Hospital (Ccdhb)
Wellington, New Zealand, 6021
Actively Recruiting
23
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, South Korea, 13620
Actively Recruiting
24
The Catholic University of Korea, Seoul St Marys Hospital
SeochoGu, Seoul Teugbyeolsi, South Korea, 06591
Actively Recruiting
25
Severance Hospital Yonsei University Health System
SeodaemunGu, Seoul Teugbyeolsi, South Korea, 03722
Actively Recruiting
26
Seoul National University Hospital
Seoul, Seoul Teugbyeolsi, South Korea, 03080
Actively Recruiting
27
Asan Medical Center
SongpaGu, Seoul Teugbyeolsi, South Korea, 05505
Actively Recruiting
28
University Hospitals Dorset Royal Bournemouth Hospital
Bournemouth, United Kingdom, BH7 7DW
Actively Recruiting
29
Kings College Hospital
London, United Kingdom, SE5 9RS
Actively Recruiting
Research Team
S
Study Director
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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